Search Results - "Winkler, Emma S"

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function by Winkler, Emma S., Bailey, Adam L., Kafai, Natasha M., Nair, Sharmila, McCune, Broc T., Yu, Jinsheng, Fox, Julie M., Chen, Rita E., Earnest, James T., Keeler, Shamus P., Ritter, Jon H., Kang, Liang-I, Dort, Sarah, Robichaud, Annette, Head, Richard, Holtzman, Michael J., Diamond, Michael S.

“…Although animal models have been evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, none have fully recapitulated the lung…”
Get full text

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein by Suryadevara, Naveenchandra, Shrihari, Swathi, Gilchuk, Pavlo, VanBlargan, Laura A., Binshtein, Elad, Zost, Seth J., Nargi, Rachel S., Sutton, Rachel E., Winkler, Emma S., Chen, Elaine C., Fouch, Mallorie E., Davidson, Edgar, Doranz, Benjamin J., Chen, Rita E., Shi, Pei-Yong, Carnahan, Robert H., Thackray, Larissa B., Diamond, Michael S., Crowe, James E.

“…Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the…”
Get full text

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection by Winkler, Emma S., Gilchuk, Pavlo, Yu, Jinsheng, Bailey, Adam L., Chen, Rita E., Chong, Zhenlu, Zost, Seth J., Jang, Hyesun, Huang, Ying, Allen, James D., Case, James Brett, Sutton, Rachel E., Carnahan, Robert H., Darling, Tamarand L., Boon, Adrianus C.M., Mack, Matthias, Head, Richard D., Ross, Ted M., Crowe, James E., Diamond, Michael S.

“…SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials,…”
Get full text

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies by Hassan, Ahmed O., Case, James Brett, Winkler, Emma S., Thackray, Larissa B., Kafai, Natasha M., Bailey, Adam L., McCune, Broc T., Fox, Julie M., Chen, Rita E., Alsoussi, Wafaa B., Turner, Jackson S., Schmitz, Aaron J., Lei, Tingting, Shrihari, Swathi, Keeler, Shamus P., Fremont, Daved H., Greco, Suellen, McCray, Paul B., Perlman, Stanley, Holtzman, Michael J., Ellebedy, Ali H., Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of…”
Get full text

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice by Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Kafai, Natasha M., Fox, Julie M., Smith, Brittany K., Shrihari, Swathi, McCune, Broc T., Harvey, Ian B., Keeler, Shamus P., Bloyet, Louis-Marie, Zhao, Haiyan, Ma, Meisheng, Adams, Lucas J., Winkler, Emma S., Holtzman, Michael J., Fremont, Daved H., Whelan, Sean P.J., Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of human infections, and an effective vaccine is critical to mitigate…”
Get full text

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice by Winkler, Emma S, Chen, Rita E, Alam, Fahmida, Yildiz, Soner, Case, James Brett, Uccellini, Melissa B, Holtzman, Michael J, Garcia-Sastre, Adolfo, Schotsaert, Michael, Diamond, Michael S

“…The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled testing of vaccines and therapeutics and defining aspects of severe acute…”
Get full text

A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection by Slon-Campos, Jose Luis, Dejnirattisai, Wanwisa, Jagger, Brett W., López-Camacho, César, Wongwiwat, Wiyada, Durnell, Lorellin A., Winkler, Emma S., Chen, Rita E., Reyes-Sandoval, Arturo, Rey, Felix A., Diamond, Michael S., Mongkolsapaya, Juthathip, Screaton, Gavin R.

“…Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive antibody responses. Two immunodominant epitopes—one to precursor membrane…”
Get full text

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals by Chen, Elaine C., Gilchuk, Pavlo, Zost, Seth J., Suryadevara, Naveenchandra, Winkler, Emma S., Cabel, Carly R., Binshtein, Elad, Chen, Rita E., Sutton, Rachel E., Rodriguez, Jessica, Day, Samuel, Myers, Luke, Trivette, Andrew, Williams, Jazmean K., Davidson, Edgar, Li, Shuaizhi, Doranz, Benjamin J., Campos, Samuel K., Carnahan, Robert H., Thorne, Curtis A., Diamond, Michael S., Crowe, James E.

“…Unrelated individuals can produce genetically similar clones of antibodies, known as public clonotypes, which have been seen in responses to different…”
Get full text

Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila by Zhang, Rong, Earnest, James T., Kim, Arthur S., Winkler, Emma S., Desai, Pritesh, Adams, Lucas J., Hu, Gaowei, Bullock, Christopher, Gold, Beth, Cherry, Sara, Diamond, Michael S.

“…Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O’nyong nyong (ONNV)…”
Get full text

MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2 by McCarthy, Mary K, Reynoso, Glennys V, Winkler, Emma S, Mack, Matthias, Diamond, Michael S, Hickman, Heather D, Morrison, Thomas E

“…Humoral immune responses initiate in the lymph node draining the site of viral infection (dLN). Some viruses subvert LN B cell activation; however, our…”
Get full text

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice by Salazar, Vanessa, Jagger, Brett W., Mongkolsapaya, Juthathip, Burgomaster, Katherine E., Dejnirattisai, Wanwisa, Winkler, Emma S., Fernandez, Estefania, Nelson, Christopher A., Fremont, Daved H., Pierson, Theodore C., Crowe, James E., Screaton, Gavin R., Diamond, Michael S.

“…Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently…”
Get full text

On the road to ending the COVID-19 pandemic: Are we there yet? by Case, James Brett, Winkler, Emma S., Errico, John M., Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged into the human population in late 2019 and caused the global COVID-19 pandemic. SARS-CoV-2…”
Get full text

A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection by Alsoussi, Wafaa B, Turner, Jackson S, Case, James B, Zhao, Haiyan, Schmitz, Aaron J, Zhou, Julian Q, Chen, Rita E, Lei, Tingting, Rizk, Amena A, McIntire, Katherine M, Winkler, Emma S, Fox, Julie M, Kafai, Natasha M, Thackray, Larissa B, Hassan, Ahmed O, Amanat, Fatima, Krammer, Florian, Watson, Corey T, Kleinstein, Steven H, Fremont, Daved H, Diamond, Michael S, Ellebedy, Ali H

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for millions of infections and hundreds of thousands of deaths globally. There are…”
Get full text

Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation by Liu, Ta-Chiang, Kern, Justin T., Jain, Umang, Sonnek, Naomi M., Xiong, Shanshan, Simpson, Katherine F., VanDussen, Kelli L., Winkler, Emma S., Haritunians, Talin, Malique, Atika, Lu, Qiuhe, Sasaki, Yo, Storer, Chad, Diamond, Michael S., Head, Richard D., McGovern, Dermot P.B., Stappenbeck, Thaddeus S.

“…Intestinal Paneth cells modulate innate immunity and infection. In Crohn’s disease, genetic mutations together with environmental triggers can disable Paneth…”
Get full text

The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis by Winkler, Emma S., Shrihari, Swathi, Hykes, Barry L., Handley, Scott A., Andhey, Prabhakar S., Huang, Yan-Jang S., Swain, Amanda, Droit, Lindsay, Chebrolu, Kranthi K., Mack, Matthias, Vanlandingham, Dana L., Thackray, Larissa B., Cella, Marina, Colonna, Marco, Artyomov, Maxim N., Stappenbeck, Thaddeus S., Diamond, Michael S.

“…Chikungunya virus (CHIKV), an emerging alphavirus, has infected millions of people. However, the factors modulating disease outcome remain poorly understood…”
Get full text

Nasally delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron by Chong, Zhenlu, Karl, Courtney E., Halfmann, Peter J., Kawaoka, Yoshihiro, Winkler, Emma S., Keeler, Shamus P., Holtzman, Michael J., Yu, Jinsheng, Diamond, Michael S.

“…Although vaccines and monoclonal antibody countermeasures have reduced the morbidity and mortality associated with severe acute respiratory syndrome…”
Get full text

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope by VanBlargan, Laura A., Adams, Lucas J., Liu, Zhuoming, Chen, Rita E., Gilchuk, Pavlo, Raju, Saravanan, Smith, Brittany K., Zhao, Haiyan, Case, James Brett, Winkler, Emma S., Whitener, Bradley M., Droit, Lindsay, Aziati, Ishmael D., Bricker, Traci L., Joshi, Astha, Shi, Pei-Yong, Creanga, Adrian, Pegu, Amarendra, Handley, Scott A., Wang, David, Boon, Adrianus C.M., Crowe, James E., Whelan, Sean P.J., Fremont, Daved H., Diamond, Michael S.

“…With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased transmissibility and potential resistance,…”
Get full text

Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease by Case, James Brett, Chen, Rita E., Cao, Longxing, Ying, Baoling, Winkler, Emma S., Johnson, Max, Goreshnik, Inna, Pham, Minh N., Shrihari, Swathi, Kafai, Natasha M., Bailey, Adam L., Xie, Xuping, Shi, Pei-Yong, Ravichandran, Rashmi, Carter, Lauren, Stewart, Lance, Baker, David, Diamond, Michael S.

“…Despite the introduction of public health measures and spike protein-based vaccines to mitigate the COVID-19 pandemic, SARS-CoV-2 infections and deaths…”
Get full text

Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets by Dugan, Haley L., Stamper, Christopher T., Li, Lei, Changrob, Siriruk, Asby, Nicholas W., Halfmann, Peter J., Zheng, Nai-Ying, Huang, Min, Shaw, Dustin G., Cobb, Mari S., Erickson, Steven A., Guthmiller, Jenna J., Stovicek, Olivia, Wang, Jiaolong, Winkler, Emma S., Madariaga, Maria Lucia, Shanmugarajah, Kumaran, Jansen, Maud O., Amanat, Fatima, Stewart, Isabelle, Utset, Henry A., Huang, Jun, Nelson, Christopher A., Dai, Ya-Nan, Hall, Paige D., Jedrzejczak, Robert P., Joachimiak, Andrzej, Krammer, Florian, Diamond, Michael S., Fremont, Daved H., Kawaoka, Yoshihiro, Wilson, Patrick C.

“…Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we used…”
Get full text

A long-distance relationship: the commensal gut microbiota and systemic viruses by Winkler, Emma S, Thackray, Larissa B

“…[Display omitted] Recent advances defining the role of the commensal gut microbiota in the development, education, induction, function, and maintenance of the…”
Get full text