Search Results - "Winkler, David T."

Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy by SCHAEFFER, Veronique, LAVENIR, Isabelle, OZCELIK, Sefika, TOLNAY, Markus, WINKLER, David T, GOEDERT, Michel

“…The accumulation of insoluble proteins is a pathological hallmark of several neurodegenerative disorders. Tauopathies are caused by the dysfunction and…”
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Cerebrospinal fluid from Alzheimer's disease patients promotes tau aggregation in transgenic mice by Skachokova, Zhiva, Martinisi, Alfonso, Flach, Martin, Sprenger, Frederik, Naegelin, Yvonne, Steiner-Monard, Viviane, Sollberger, Marc, Monsch, Andreas U, Goedert, Michel, Tolnay, Markus, Winkler, David T

“…Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer's disease (AD). Tau derived from AD patients' brains induces tau aggregation in a…”
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Severe oligomeric tau toxicity can be reversed without long-term sequelae by Martinisi, Alfonso, Flach, Martin, Sprenger, Frederik, Frank, Stephan, Tolnay, Markus, Winkler, David T

“…Tau is a microtubule stabilizing protein that forms abnormal aggregates in many neurodegenerative disorders, including Alzheimer's disease. We have previously…”
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Trans‐seeding of Alzheimer‐related tau protein by a yeast prion by Flach, Martin, Leu, Cedric, Martinisi, Alfonso, Skachokova, Zhiva, Frank, Stephan, Tolnay, Markus, Stahlberg, Henning, Winkler, David T.

“…Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic…”
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When childhood ends: estimating the age of young people by Messelken, Daniel, Crouse, Johan, Winkler, David T

“…Doctors should tread carefully through this ethical minefield…”
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Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid by FRITSCHI, Sarah K, LANGER, Franziska, SPITZER, Philipp, WILTFANG, Jens, SCHIERLE, Gabriele S. Kaminski, ZETTERBERG, Henrik, STAUFENBIEL, Matthias, JUCKER, Mathias, KAESER, Stephan A, MAIA, Luis F, PORTELIUS, Erik, PINOTSI, Dorothea, KAMINSKI, Clemens F, WINKLER, David T, MAETZLER, Walter, KEYVANI, Kathy

“…The soluble fraction of brain samples from patients with Alzheimer's disease contains highly biologically active amyloid-β seeds. In this study, we sought to…”
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Thrombolysis in Stroke Mimics : Frequency, Clinical Characteristics, and Outcome by WINKLER, David T, FLURI, Felix, FUHR, Peter, WETZEL, Stephan G, LYRER, Philippe A, RUEGG, Stephan, ENGELTER, Stefan T

“…Intravenous thrombolysis for acute ischemic stroke is usually based on clinical assessment, blood test results, and CT findings. Intravenous thrombolysis of…”
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Cystatin C modulates cerebral β-amyloidosis by Herzig, Martin C, Grubb, Anders, Kaeser, Stephan A, Kilger, Ellen, Staufenbiel, Matthias, Jucker, Mathias, Selenica, Maj-Linda, Winkler, David T, Coomaraswamy, Janaky, Levy, Efrat

“…The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show…”
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Intravenous levetiracetam: Treatment experience with the first 50 critically ill patients by Rüegg, Stephan, Naegelin, Yvonne, Hardmeier, Martin, Winkler, David T, Marsch, Stephan, Fuhr, Peter

“…Abstract Levetiracetam (LEV) is a broad-spectrum antiepileptic drug with no known interactions and a favorable profile of adverse events. These properties make…”
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Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis by Jucker, Mathias, Herzig, Martin C, Winkler, David T, Burgermeister, Patrick, Pfeifer, Michelle, Kohler, Esther, Schmidt, Stephen D, Danner, Simone, Abramowski, Dorothee, Stürchler-Pierrat, Christine, Bürki, Kurt, van Duinen, Sjoerd G, Maat-Schieman, Marion L C, Staufenbiel, Matthias, Mathews, Paul M

“…The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent cerebral hemorrhagic strokes and…”
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TREX1 C-terminal frameshift mutations in the systemic variant of retinal vasculopathy with cerebral leukodystrophy by DiFrancesco, Jacopo C., Novara, Francesca, Zuffardi, Orsetta, Forlino, Antonella, Gioia, Roberta, Cossu, Federica, Bolognesi, Martino, Andreoni, Simona, Saracchi, Enrico, Frigeni, Barbara, Stellato, Tiziana, Tolnay, Markus, Winkler, David T., Remida, Paolo, Isimbaldi, Giuseppe, Ferrarese, Carlo

“…Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an adult-onset disorder caused by C-terminal heterozygous frameshift (fs) mutations in the human…”
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Rapid Cerebral Amyloid Binding by Aβ Antibodies Infused into β-Amyloid Precursor Protein Transgenic Mice by Winkler, David T, Abramowski, Dorothee, Danner, Simone, Zurini, Mauro, Paganetti, Paolo, Tolnay, Markus, Staufenbiel, Matthias

“…Background Passive immunization for the treatment of Alzheimer's disease (AD) was rapidly translated into clinical trials. However, basic mechanisms of AD…”
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Facial nerve palsy and anti-Ku autoantibodies by Sutter, Raoul, Mengiardi, Bernard, Benz, Daniela, Heijnen, Ingmar, Kappos, Ludwig, Winkler, David T.

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Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy by Winkler, David T, Bondolfi, Luca, Herzig, Martin C, Jann, Lukas, Calhoun, Michael E, Wiederhold, Karl-Heinz, Tolnay, Markus, Staufenbiel, Matthias, Jucker, Mathias

“…A high risk factor for spontaneous and often fatal lobar hemorrhage is cerebral amyloid angiopathy (CAA). We now report that CAA in an amyloid precursor…”
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Amyloid-β in the Cerebrospinal Fluid of APP Transgenic Mice Does not Show Prion-like Properties by Skachokova, Zhiva, Sprenger, Frederik, Breu, Karin, Abramowski, Dorothee, Clavaguera, Florence, Hench, Jürgen, Staufenbiel, Matthias, Tolnay, Markus, Winkler, David T

“…Early diagnosis of Alzheimer`s disease (AD) is currently difficult and involves a complex approach including clinical assessment, neuroimaging, and measurement…”
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Swiss national MD-PhD-program: an outcome analysis by Kuehnle, Katrin, Winkler, David T, Meier-Abt, Peter J

“…This study aims at a first evaluation of the outcome of the Swiss national MD-PhD program during the last 16 years. One hundred and twenty six former and…”
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Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy by Winkler, David T., Biedermann, Luc, Tolnay, Markus, Allegrini, Peter R., Staufenbiel, Matthias, Wiessner, Christoph, Jucker, Mathias

“…We studied the impact of cerebral amyloid angiopathy on tissue plasminogen activator‐induced cerebral hemorrhages in APP23 transgenic mice. Results show that…”
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Mechanisms of Cerebrovascular Amyloid Deposition: Lessons from Mouse Models by BURGERMEISTER, PATRICK, CALHOUN, MICHAEL E., WINKLER, DAVID T., JUCKER, MATHIAS

“…: Cerebrovascular deposition of amyloid is a frequent observation in Alzheimer's disease patients. It can also be detected sporadically in normal aged…”
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Cystatin C modulates cerebral b-amyloidosis by Kaeser, Stephan A, Herzig, Martin C, Coomaraswamy, Janaky, Kilger, Ellen, Selenica, Maj-Linda, Winkler, David T, Staufenbiel, Matthias, Levy, Efrat, Grubb, Anders, Jucker, Mathias

“…The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show…”
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