Search Results - "Winkler, David G"

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ by Uehara, Mayuko, McGrath, Martina M., Ohori, Shunsuke, Solhjou, Zhabiz, Banouni, Naima, Routray, Sujit, Evans, Catherine, DiNitto, Jonathan P., Elkhal, Abdallah, Turka, Laurence A., Strom, Terry B., Tullius, Stefan G., Winkler, David G., Azzi, Jamil, Abdi, Reza

“…Phosphatidylinositol-3-kinases (PI3K) γ and δ are preferentially enriched in leukocytes, and defects in these signaling pathways have been shown to impair T…”
Get full text

The Selective Phosphoinoside-3-Kinase p110δ Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation by Chiu, Honyin, Mallya, Sharmila, Nguyen, Phuongthao, Mai, Annie, Jackson, Leandra V, Winkler, David G, DiNitto, Jonathan P, Brophy, Erin E, McGovern, Karen, Kutok, Jeffery L, Fruman, David A

“…The class I phosphoinoside-3-kinases (PI3Ks) are important enzymes that relay signals from cell surface receptors to downstream mediators driving cellular…”
Get full text

Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation by Sutherland, May Kung, Geoghegan, James C., Yu, Changpu, Turcott, Eileen, Skonier, John E., Winkler, David G., Latham, John A.

“…A null mutation in the SOST gene is associated with sclerosteosis, an inherited disorder characterized by a high bone mass phenotype. The protein product of…”
Get full text

Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins by Winkler, David G., Sutherland, May S. Kung, Ojala, Ethan, Turcott, Eileen, Geoghegan, James C., Shpektor, Diana, Skonier, John E., Yu, Changpu, Latham, John A.

“…High bone mass diseases are caused both by activating mutations in the Wnt pathway and by loss of SOST, a bone morphogenetic protein (BMP) antagonist, leading…”
Get full text

PI3Kγ is a molecular switch that controls immune suppression by Kaneda, Megan M., Messer, Karen S., Ralainirina, Natacha, Li, Hongying, Leem, Christopher J., Gorjestani, Sara, Woo, Gyunghwi, Nguyen, Abraham V., Figueiredo, Camila C., Foubert, Philippe, Schmid, Michael C., Pink, Melissa, Winkler, David G., Rausch, Matthew, Palombella, Vito J., Kutok, Jeffery, McGovern, Karen, Frazer, Kelly A., Wu, Xuefeng, Karin, Michael, Sasik, Roman, Cohen, Ezra E. W., Varner, Judith A.

“…Modulation of PI3Kγ activity regulates macrophage polarization during inflammation and cancer, whilst combining PI3Kγ inhibition with immune checkpoint…”
Get full text

Unique regulation of SOST, the sclerosteosis gene, by BMPs and steroid hormones in human osteoblasts by Sutherland, May Kung, Geoghegan, James C, Yu, Changpu, Winkler, David G, Latham, John A

“…SOST, a novel bone morphogenetic protein (BMP) antagonist and negative regulator of bone formation, is expressed in osteogenic cells. Null mutations in the…”
Get full text

Noggin and Sclerostin Bone Morphogenetic Protein Antagonists Form a Mutually Inhibitory Complex by Winkler, David G, Yu, Changpu, Geoghegan, James C, Ojala, Ethan W, Skonier, John E, Shpektor, Diana, Sutherland, May K, Latham, John A

“…Noggin and sclerostin are bone morphogenetic protein (BMP) antagonists that modulate mitogenic activity through sequestering BMPs. Little is known of the…”
Get full text

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)‑γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate by Evans, Catherine A, Liu, Tao, Lescarbeau, André, Nair, Somarajan J, Grenier, Louis, Pradeilles, Johan A, Glenadel, Quentin, Tibbitts, Thomas, Rowley, Ann M, DiNitto, Jonathan P, Brophy, Erin E, O’Hearn, Erin L, Ali, Janid A, Winkler, David G, Goldstein, Stanley I, O’Hearn, Patrick, Martin, Christian M, Hoyt, Jennifer G, Soglia, John R, Cheung, Culver, Pink, Melissa M, Proctor, Jennifer L, Palombella, Vito J, Tremblay, Martin R, Castro, Alfredo C

“…Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid…”
Get full text

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist by Latham, John A, Winkler, David G, Sutherland, May Kung, Geoghegan, James C, Yu, Changpu, Hayes, Trenton, Skonier, John E, Shpektor, Diana, Jonas, Mechtild, Kovacevich, Brian R, Staehling-Hampton, Karen, Appleby, Mark, Brunkow, Mary E

“…There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic bone disorders provide insight into bone regulatory processes…”
Get full text

Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for advanced glycation end product-dependent manner by Ruan, Benfang Helen, Li, Xin, Winkler, Aaron R, Cunningham, Kristina M, Kuai, Jun, Greco, Rita M, Nocka, Karl H, Fitz, Lori J, Wright, Jill F, Pittman, Debra D, Tan, Xiang-Yang, Paulsen, Janet E, Lin, Lih Ling, Winkler, David G

“…The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor implicated in a number of diseases including autoimmune…”
Get full text

Corrigendum: PI3Kγ is a molecular switch that controls immune suppression by Kaneda, Megan M, Messer, Karen S, Ralainirina, Natacha, Li, Hongying, Leem, Christopher J, Gorjestani, Sara, Woo, Gyunghwi, Nguyen, Abraham V, Figueiredo, Camila C, Foubert, Philippe, Schmid, Michael C, Pink, Melissa, Winkler, David G, Rausch, Matthew, Palombella, Vito J, Kutok, Jeffery, McGovern, Karen, Frazer, Kelly A, Wu, Xuefeng, Karin, Michael, Sasik, Roman, Cohen, Ezra E W, Varner, Judith A

Get full text

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines by Kuai, Jun, Gregory, Bernard, Hill, Andrew, Pittman, Debra D., Feldman, Jeffrey L., Brown, Tom, Carito, Brenda, O’Toole, Margot, Ramsey, Renee, Adolfsson, Oskar, Shields, Kathleen M., Dower, Ken, Hall, J. Perry, Kurdi, Yahya, Beech, Jonathan T., Nanchahal, Jagdeep, Feldmann, Marc, Foxwell, Brian M., Brennan, Fionula M., Winkler, David G., Lin, Lih-Ling

“…Objectives. To investigate the expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) in the synovium of human RA patients as…”
Get full text

Complex responses to a diverse environment by Collins, Mary, Winkler, David G, Lin, Lih-Ling

“…A report on the Keystone Symposium 'Innate Immunity: Signaling Mechanisms', Keystone, USA, 24-29 February, 2008…”
Get full text

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models by Winkler, David G., Faia, Kerrie L., DiNitto, Jonathan P., Ali, Janid A., White, Kerry F., Brophy, Erin E., Pink, Melissa M., Proctor, Jennifer L., Lussier, Jennifer, Martin, Christian M., Hoyt, Jennifer G., Tillotson, Bonnie, Murphy, Erin L., Lim, Alice R., Thomas, Brian D., MacDougall, John R., Ren, Pingda, Liu, Yi, Li, Lian-Sheng, Jessen, Katti A., Fritz, Christian C., Dunbar, Joi L., Porter, James R., Rommel, Christian, Palombella, Vito J., Changelian, Paul S., Kutok, Jeffery L.

“…Phosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in immune cells, and inhibitors targeting these isoforms are hypothesized to have…”
Get full text

Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity by Winkler, David G., Cutler, Richard E., Drugan, Jonelle K., Campbell, Sharon, Morrison, Deborah K., Cooper, Jonathan A.

“…We have identified mutations in Raf-1 that increase binding to Ras. The mutations were identified making use of three mutant forms of Ras that have reduced…”
Get full text

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56(lck) by Winkler, David G, Park, Indal, Kim, TaeUe, Payne, Nicola S

“…In vitro kinase assays show that Ser-59 can be uniquely phosphorylated by mitogen-activated protein kinase and that Ser-42 can be phosphorylated by either…”
Get full text

Identification and Characterization of Mutations in Ha-Ras That Selectively Decrease Binding to cRaf-1 by Winkler, David G., Johnson, Jeffrey C., Cooper, Jonathan A., Vojtek, Anne B.

“…The oncoprotein Ras transforms cells by binding to one or more effector proteins. Effector proteins have been identified by their ability to bind to Ras in the…”
Get full text

Corrigendum: PI3K is a molecular switch that controls immune suppression by Kaneda, Megan M, Messer, Karen S, Ralainirina, Natacha, Li, Hongying, Leem, Christopher J, Gorjestani, Sara, Woo, Gyunghwi, Nguyen, Abraham V, Figueiredo, Camila C, Foubert, Philippe, Schmid, Michael C, Pink, Melissa, Winkler, David G, Rausch, Matthew, Palombella, Vito J, Kutok, Jeffery, McGovern, Karen, Frazer, Kelly A, Wu, Xuefeng, Karin, Michael, Sasik, Roman, Cohen, Ezra E. W, Varner, Judith A

Get full text

Correction: Corrigendum: PI3Kγ is a molecular switch that controls immune suppression by Kaneda, Megan M., Messer, Karen S., Ralainirina, Natacha, Li, Hongying, Leem, Christopher J., Gorjestani, Sara, Woo, Gyunghwi, Nguyen, Abraham V., Figueiredo, Camila C., Foubert, Philippe, Schmid, Michael C., Pink, Melissa, Winkler, David G., Rausch, Matthew, Palombella, Vito J., Kutok, Jeffery, McGovern, Karen, Frazer, Kelly A., Wu, Xuefeng, Karin, Michael, Sasik, Roman, Cohen, Ezra E. W., Varner, Judith A.

“…Nature 539, 437–442 (2016); doi:10.1038/nature19834 In this Letter, the Gene Expression Omnibus (GEO) accession number for the RNA sequencing data (for in vivo…”
Get full text

Erratum: Corrigendum: PI3Kγ is a molecular switch that controls immune suppression by Kaneda, Megan M., Messer, Karen S., Ralainirina, Natacha, Li, Hongying, Leem, Christopher J., Gorjestani, Sara, Woo, Gyunghwi, Nguyen, Abraham V., Figueiredo, Camila C., Foubert, Philippe, Schmid, Michael C., Pink, Melissa, Winkler, David G., Rausch, Matthew, Palombella, Vito J., Kutok, Jeffery, McGovern, Karen, Frazer, Kelly A., Wu, Xuefeng, Karin, Michael, Sasik, Roman, Cohen, Ezra E. W., Varner, Judith A.

Get full text