Search Results - "Winkler, Annika"

Pseudomonas carnis sp. nov., isolated from meat by Lick, Sonja, Kröckel, Lothar, Wibberg, Daniel, Winkler, Annika, Blom, Jochen, Bantleon, Annegret, Goesmann, Alexander, Kalinowski, Jörn

“…During investigations of spoilage-associated meat microbiota, isolates were found in two different laboratories showing highest similarities to DSM 29167 , DSM…”
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CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing by Andersch, Lena, Radke, Josefine, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Schumann, Elisa, Grunewald, Laura, Zirngibl, Felix, Flemmig, Carina, Jensen, Michael C, Rossig, Claudia, Joussen, Antonia, Henssen, Anton, Eggert, Angelika, Schulte, Johannes H, Künkele, Annette

“…Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical…”
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Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma by Arnhold, Viktor, Schmelz, Karin, Proba, Jutta, Winkler, Annika, Wünschel, Jasmin, Toedling, Joern, Deubzer, Hedwig E, Künkele, Annette, Eggert, Angelika, Schulte, Johannes H, Hundsdoerfer, Patrick

“…Fewer than 50% of patients with high-risk neuroblastoma survive five years after diagnosis with current treatment protocols. Molecular targeted therapies are…”
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Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells by Berlak, Mareike, Tucker, Elizabeth, Dorel, Mathurin, Winkler, Annika, McGearey, Aleixandria, Rodriguez-Fos, Elias, da Costa, Barbara Martins, Barker, Karen, Fyle, Elicia, Calton, Elizabeth, Eising, Selma, Ober, Kim, Hughes, Deborah, Koutroumanidou, Eleni, Carter, Paul, Stankunaite, Reda, Proszek, Paula, Jain, Neha, Rosswog, Carolina, Dorado-Garcia, Heathcliff, Molenaar, Jan Jasper, Hubank, Mike, Barone, Giuseppe, Anderson, John, Lang, Peter, Deubzer, Hedwig Elisabeth, Künkele, Annette, Fischer, Matthias, Eggert, Angelika, Kloft, Charlotte, Henssen, Anton George, Boettcher, Michael, Hertwig, Falk, Blüthgen, Nils, Chesler, Louis, Schulte, Johannes Hubertus

“…Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients…”
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A Reproducible Bioprinted 3D Tumor Model Serves as a Preselection Tool for CAR T Cell Therapy Optimization by Grunewald, Laura, Lam, Tobias, Andersch, Lena, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Gauert, Anton, Heeren-Hagemann, Anja I., Astrahantseff, Kathy, Klironomos, Filippos, Thomas, Alexander, Deubzer, Hedwig E., Henssen, Anton G., Eggert, Angelika, Schulte, Johannes H., Anders, Kathleen, Kloke, Lutz, Künkele, Annette

“…Chimeric antigen receptor (CAR) T cell performance against solid tumors in mouse models and clinical trials is often less effective than predicted by CAR…”
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Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN by Fuchs, Steffen, Danßmann, Clara, Klironomos, Filippos, Winkler, Annika, Fallmann, Jörg, Kruetzfeldt, Louisa-Marie, Szymansky, Annabell, Naderi, Julian, Bernhart, Stephan H., Grunewald, Laura, Helmsauer, Konstantin, Rodriguez-Fos, Elias, Kirchner, Marieluise, Mertins, Philipp, Astrahantseff, Kathy, Suenkel, Christin, Toedling, Joern, Meggetto, Fabienne, Remke, Marc, Stadler, Peter F., Hundsdoerfer, Patrick, Deubzer, Hedwig E., Künkele, Annette, Lang, Peter, Fuchs, Jörg, Henssen, Anton G., Eggert, Angelika, Rajewsky, Nikolaus, Hertwig, Falk, Schulte, Johannes H.

“…Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression…”
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Impact of a booster dose on SARS-CoV2 mRNA vaccine-specific humoral-, B- and T cell immunity in pediatric stem cell transplant recipients by Thole, Linda Marie Laura, Tóth, Laura, Proß, Vanessa, Siegle, Janine, Stahl, Carolin, Hermsdorf, Georg, Knabe, Annette, Winkler, Annika, Schrezenmeier, Eva, Ludwig, Carolin, Eckert, Cornelia, Eggert, Angelika, Schrezenmeier, Hubert, Sattler, Arne, Schulte, Johannes H, Kotsch, Katja

“…Stem cell transplant recipients (SCTR) are imperiled to increased risks after SARS-CoV2 infection, supporting the need for effective vaccination strategies for…”
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Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4 + CAR T Cell Efficacy by Ali, Solin, Toews, Karin, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Grunewald, Laura, Oevermann, Lena, Deubzer, Hedwig E, Tüns, Alicia, Jensen, Michael C, Henssen, Anton G, Eggert, Angelika, Schulte, Johannes H, Schwich, Esther, Rebmann, Vera, Schramm, Alexander, Künkele, Annette

“…Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived…”
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Publisher Correction: Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma by Koche, Richard P., Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C., Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Garcia, Heathcliff Dorado, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F., Eggert, Angelika, Torrents, David, Schulte, Johannes H., Henssen, Anton G.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma by Koche, Richard P., Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C., Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Dorado Garcia, Heathcliff, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F., Eggert, Angelika, Torrents, David, Schulte, Johannes H., Henssen, Anton G.

“…Extrachromosomal circularization of DNA is an important genomic feature in cancer. However, the structure, composition and genome-wide frequency of…”
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Pseudomonas paracarnis sp. nov., isolated from refrigerated beef by Lick, Sonja, Wibberg, Daniel, Winkler, Annika, Blom, Jochen, Grimmler, Christina, Goesmann, Alexander, Kalinowski, Jörn, Kröckel, Lothar

“…During a project focusing on the diversity of meat microbiota associated with beef ripening, a strain was isolated exhibiting high 16S rRNA gene sequence…”
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Pseudomonas paraversuta sp. nov. isolated from refrigerated dry-aged beef by Lick, Sonja, Wibberg, Daniel, Winkler, Annika, Blom, Jochen, Grimmler, Christina, Goesmann, Alexander, Kalinowski, Jörn, Kröckel, Lothar

“…A polyphasic approach was applied to investigate the diversity of microbiota that evolved during cold storage beef ripening. Isolate V4/DAB/S4/2a T with a…”
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Pseudomonas bubulae sp. nov., isolated from beef by Lick, Sonja, Kröckel, Lothar, Wibberg, Daniel, Winkler, Annika, Blom, Jochen, Goesmann, Alexander, Kalinowski, Jörn

“…Two isolates derived independently from raw refrigerated processing meat of bovine origin intended for the manufacture of Bologna-type cooked sausage could be…”
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Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN‐amplified neuroblastoma by Arlt, Birte, Zasada, Christin, Baum, Katharina, Wuenschel, Jasmin, Mastrobuoni, Guido, Lodrini, Marco, Astrahantseff, Kathy, Winkler, Annika, Schulte, Johannes H., Finkler, Sabine, Forbes, Martin, Hundsdoerfer, Patrick, Guergen, Dennis, Hoffmann, Jens, Wolf, Jana, Eggert, Angelika, Kempa, Stefan, Deubzer, Hedwig E.

“…Here we sought metabolic alterations specifically associated with MYCN amplification as nodes to indirectly target the MYCN oncogene. Liquid…”
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Abstract 1820: Circular RNAs contribute to neuroblastoma pathogenesis by Klironomos, Filippos, Danssmann, Clara, Naderi, Julian, Winkler, Annika, Luz, Uschi, Hundsdoerfer, Patrick, Eggert, Angelika, Toedling, Joern, Hertwig, Falk, Schulte, Johannes H., Fuchs, Steffen

“…Abstract Circular RNAs (circRNAs), a noncoding RNA class originating from alternative splicing, are highly abundant in neural tissues and can regulate gene…”
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Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells by Toews, Karin, Grunewald, Laura, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Ali, Solin, Zirngibl, Felix, Astrahantseff, Kathy, Wagner, Dimitrios L., Henssen, Anton G., Deubzer, Hedwig E., Schulte, Johannes H., Ochsenreither, Sebastian, Eggert, Angelika, Künkele, Annette

“…The immunosuppressive microenvironment in solid tumors is thought to form a barrier to the entry and efficacy of cell‐based therapies such as chimeric antigen…”
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CD28 Co-Stimulus Achieves Superior CAR T Cell Effector Function against Solid Tumors Than 4-1BB Co-Stimulus by Textor, Ana, Grunewald, Laura, Anders, Kathleen, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Stecklum, Maria, Rolff, Jana, Henssen, Anton G, Höpken, Uta E, Eggert, Angelika, Schulte, Johannes H, Jensen, Michael C, Blankenstein, Thomas, Künkele, Annette

“…Spacer or co-stimulatory components in chimeric antigen receptor (CAR) design influence CAR T cell effector function. Few preclinical mouse models optimally…”
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Inhibiting Lysine Demethylase 1A Improves L1CAM-Specific CAR T Cell Therapy by Unleashing Antigen-Independent Killing via the FAS-FASL Axis by Sulejmani, Ornela, Grunewald, Laura, Andersch, Lena, Schwiebert, Silke, Klaus, Anika, Winkler, Annika, Astrahantseff, Kathy, Eggert, Angelika, Henssen, Anton G., Schulte, Johannes H., Anders, Kathleen, Künkele, Annette

“…Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising treatment strategy, however, therapeutic success against solid tumors such as…”
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