Search Results - "Winkeler, Alexandra"

Imaging of the glioma microenvironment by TSPO PET by Zinnhardt, Bastian, Roncaroli, Federico, Foray, Claudia, Agushi, Erjon, Osrah, Bahiya, Hugon, Gaëlle, Jacobs, Andreas H., Winkeler, Alexandra

“…Gliomas are highly dynamic and heterogeneous tumours of the central nervous system (CNS). They constitute the most common neoplasm of the CNS and the second…”
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Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake by Zinnhardt, Bastian, Pigeon, Hayet, Thézé, Benoit, Viel, Thomas, Wachsmuth, Lydia, Fricke, Inga B, Schelhaas, Sonja, Honold, Lisa, Schwegmann, Katrin, Wagner, Stefan, Faust, Andreas, Faber, Cornelius, Kuhlmann, Michael T, Hermann, Sven, Schäfers, Michael, Winkeler, Alexandra, Jacobs, Andreas H

“…The tumor microenvironment is highly heterogeneous. For gliomas, the tumor-associated inflammatory response is pivotal to support growth and invasion. Factors…”
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[18F]2-Fluoro-2-deoxy-sorbitol PET Imaging for Quantitative Monitoring of Enhanced Blood-Brain Barrier Permeability Induced by Focused Ultrasound by Hugon, Gaëlle, Goutal, Sébastien, Dauba, Ambre, Breuil, Louise, Larrat, Benoit, Winkeler, Alexandra, Novell, Anthony, Tournier, Nicolas

“…Focused ultrasound in combination with microbubbles (FUS) provides an effective means to locally enhance the delivery of therapeutics to the brain…”
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TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model by Chevaleyre, Céline, Kereselidze, Dimitri, Caillé, Fabien, Tournier, Nicolas, Olaciregui, Nagore G., Winkeler, Alexandra, Declèves, Xavier, Jego, Benoit, Cisternino, Salvatore, Auvity, Sylvain, Truillet, Charles

“…Diffuse intrinsic pontine gliomas (DIPG), the first cause of cerebral pediatric cancer death, will greatly benefit from specific and non-invasive biomarkers…”
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In Vivo Quantitative Imaging of Glioma Heterogeneity Employing Positron Emission Tomography by Barca, Cristina, Foray, Claudia, Zinnhardt, Bastian, Winkeler, Alexandra, Herrlinger, Ulrich, Grauer, Oliver M., Jacobs, Andreas H.

“…Glioblastoma is the most common primary brain tumor, highly aggressive by being proliferative, neovascularized and invasive, heavily infiltrated by…”
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Impact of Donepezil on Brain Glucose Metabolism Assessed Using [ 18 F]2-Fluoro-2-deoxy-D-Glucose Positron Emission Tomography Imaging in a Mouse Model of Alzheimer's Disease Induced by Intracerebroventricular Injection of Amyloid-Beta Peptide by Hugon, Gaëlle, Goutal, Sébastien, Sarazin, Marie, Bottlaender, Michel, Caillé, Fabien, Droguerre, Marine, Charvériat, Mathieu, Winkeler, Alexandra, Tournier, Nicolas

“…Translational methods are needed to monitor the impact of the Alzheimer's disease (AD) and therapies on brain function in animal models and patients. The…”
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The translocator protein ligand [18F]DPA-714 images glioma and activated microglia in vivo by Winkeler, Alexandra, Boisgard, Raphael, Awde, Ali R., Dubois, Albertine, Thézé, Benoit, Zheng, Jinzi, Ciobanu, Luisa, Dollé, Frédéric, Viel, Thomas, Jacobs, Andreas H., Tavitian, Bertrand

“…Purpose In recent years there has been an increase in the development of radioligands targeting the 18-kDa translocator protein (TSPO). TSPO expression is well…”
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Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state by Villa, Alessandro, Klein, Barbara, Janssen, Bieneke, Pedragosa, Jordi, Pepe, Giovanna, Zinnhardt, Bastian, Vugts, Danielle J, Gelosa, Paolo, Sironi, Luigi, Beaino, Wissam, Damont, Annelaure, Dollé, Frédéric, Jego, Benoit, Winkeler, Alexandra, Ory, Dieter, Solin, Olof, Vercouillie, Johnny, Funke, Uta, Laner-Plamberger, Sandra, Blomster, Linda V, Christophersen, Palle, Vegeto, Elisabetta, Aigner, Ludwig, Jacobs, Andreas, Planas, Anna M, Maggi, Adriana, Windhorst, Albert D

“…Microglia are potential targets for therapeutic intervention in neurological and neurodegenerative diseases affecting the central nervous system. In order to…”
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Bystander Killing of Malignant Glioma by Bone Marrow–derived Tumor-Infiltrating Progenitor Cells Expressing a Suicide Gene by Miletic, Hrvoje, Fischer, Yvonne, Litwak, Sara, Giroglou, Tsanan, Waerzeggers, Yannic, Winkeler, Alexandra, Li, Huongfeng, Himmelreich, Uwe, Lange, Claudia, Stenzel, Werner, Deckert, Martina, Neumann, Harald, Jacobs, Andreas H, von Laer, Dorothee

“…Adult stem cells are promising cellular vehicles for therapy of malignant gliomas as they have the ability to migrate into these tumors and even track…”
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Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation by Zheng, Jinzi, Winkeler, Alexandra, Peyronneau, Marie-Anne, Dollé, Frédéric, Boisgard, Raphaël

“…Purpose Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and…”
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Early detection of erlotinib treatment response in NSCLC by 3'-deoxy-3'-[F]-fluoro-L-thymidine ([F]FLT) positron emission tomography (PET) by Ullrich, Roland T, Zander, Thomas, Neumaier, Bernd, Koker, Mirjam, Shimamura, Takeshi, Waerzeggers, Yannic, Borgman, Christa L, Tawadros, Samir, Li, Hongfeng, Sos, Martin L, Backes, Heiko, Shapiro, Geoffrey I, Wolf, Jürgen, Jacobs, Andreas H, Thomas, Roman K, Winkeler, Alexandra

“…Inhibition of the epidermal growth factor receptor (EGFR) has shown clinical success in patients with advanced non-small cell lung cancer (NSCLC). Somatic…”
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Performance evaluation of the microPET R4 PET scanner for rodents by KNOESS, Christof, SIEGEL, Stefan, HEISS, Wolf-Dieter, SMITH, Anne, NEWPORT, Danny, RICHERZHAGEN, Norbert, WINKELER, Alexandra, JACOBS, Andreas, GOBLE, Rhonda N, GRAF, Rudolf, WIENHARD, Klaus

“…The microPET R4 scanner is a dedicated positron emission tomograph (PET) for studies of rodents. A number of scanner parameters such as spatial resolution,…”
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Cholera Toxin Is Exported from Microsomes by the Sec61p Complex by Schmitz, Anton, Herrgen, Helga, Winkeler, Alexandra, Herzog, Volker

“…After endocytosis cholera toxin is transported to the endoplasmic reticulum (ER), from where its A1 subunit (CTA1) is assumed to be transferred to the cytosol…”
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Application of advanced brain positron emission tomography–based molecular imaging for a biological framework in neurodegenerative proteinopathies by Perani, Daniela, Iaccarino, Leonardo, Jacobs, Andreas H., Lammertsma, Adriaan A., Nordberg, Agneta, Windhorst, Albert D., Gerhard, Alexander, Winkeler, Alexandra, Jacobs, Andreas H., Gee, Anthony, Kuhnast, Bertrand, Halldin, Christer, Perani, Daniela, Brooks, David, Rodriguez-Vieitez, Elena, Turkheimer, Federico E., López-Picón, Francisco, Knudsen, Gitte M., Vercouillie, Johnny, Rinne, Juha O., Herholz, Karl, Van Laere, Koen, Varrone, Andrea, Santiago-Ribeiro, Marie Joao, Herth, Matthias M., Carroll, Michael A., Chalon, Sylvie, Bottlaender, Michel, Hansson, Oskar, Edison, Paul, Hinz, Rainer, Boellaard, Ronald, Moresco, Rosa Maria, Pappata, Sabina

“…A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing…”
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The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model by Awde, Ali R, Boisgard, Raphaël, Thézé, Benoit, Dubois, Albertine, Zheng, Jinzi, Dollé, Frédéric, Jacobs, Andreas H, Tavitian, Bertrand, Winkeler, Alexandra

“…On the one hand, the translocator protein (TSPO) radioligand…”
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Imaging Bone Morphogenetic Protein 7 Induced Cell Cycle Arrest in Experimental Gliomas by Klose, Anke, Waerzeggers, Yannic, Monfared, Parisa, Vukicevic, Slobodan, Kaijzel, Eric L, Winkeler, Alexandra, Wickenhauser, Claudia, Löwik, Clemens W.G.M, Jacobs, Andreas H

“…Bone morphogenetic protein 7 (BMP-7) belongs to the superfamily of transforming growth factor β-like cytokines, which can act either as tumor suppressors or as…”
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Radioisotopic Imaging of Neuroinflammation: FIGURE 1. by Winkeler, Alexandra, Boisgard, Raphaël, Martin, Abraham, Tavitian, Bertrand

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Normal Brain Cells Contribute to the Bystander Effect in Suicide Gene Therapy of Malignant Glioma by MILETIC, Hrvoje, FISCHER, Yvonne Heidemarie, GIROGLOU, Tsanan, RUEGER, Maria Adele, WINKELER, Alexandra, HUONGFENG LI, HIMMELREICH, Uwe, STENZEL, Werner, JACOBS, Andreas H, VON LAER, Dorothee

“…Purpose: Lentiviral vectors pseudotyped with glycoproteins of the lymphocytic choriomeningitis virus (LCMV-GP) are promising candidates for gene therapy of…”
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Multimodal Imaging of Neural Progenitor Cell Fate in Rodents by Waerzeggers, Yannic, Klein, Markus, Miletic, Hrvoje, Himmelreich, Uwe, Li, Hongfeng, Monfared, Parisa, Herrlinger, Ulrich, Hoehn, Mathias, Coenen, Heinrich Hubert, Weller, Michael, Winkeler, Alexandra, Jacobs, Andreas Hans

“…For clinical application of stem cell–based therapies, noninvasive detection of applied stem cells is of high importance. We report on the feasibility of…”
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Switching on the lights for gene therapy by Winkeler, Alexandra, Sena-Esteves, Miguel, Paulis, Leonie E M, Li, Hongfeng, Waerzeggers, Yannic, Rückriem, Benedikt, Himmelreich, Uwe, Klein, Markus, Monfared, Parisa, Rueger, Maria A, Heneka, Michael, Vollmar, Stefan, Hoehn, Mathias, Fraefel, Cornel, Graf, Rudolf, Wienhard, Klaus, Heiss, Wolf D, Jacobs, Andreas H

“…Strategies for non-invasive and quantitative imaging of gene expression in vivo have been developed over the past decade. Non-invasive assessment of the…”
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