Search Results - "Wingrove, Peter B"

The non‐peptidyl fungal metabolite L‐783,281 activates TRK neurotrophin receptors by Wilkie, Neil, Wingrove, Peter B., Bilsland, James G., Young, Lisa, Harper, Sarah J., Hefti, Franz, Ellis, Semantha, Pollack, Scott J.

“…Neurotrophin binding to the extracellular surface of the Trk family of tyrosine kinase receptors leads to the activation of multiple signalling cascades,…”
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Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors by Thompson, Sally-Anne, Wingrove, Peter B, Connelly, Linda, Whiting, Paul J, Wafford, Keith A

“…Tracazolate, a pyrazolopyridine, is an anxiolytic known to interact with gamma-aminobutyric acid (GABA)(A) receptors, adenosine receptors, and…”
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Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation by Thompson, S A, Smith, M Z, Wingrove, P B, Whiting, P J, Wafford, K A

“…We have mutated a conserved leucine in the putative membrane-spanning domain to serine in human GABA(A) beta2 and investigated the actions of a number of…”
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Characterisation of N‐Methyl‐D‐Aspartate Receptor‐Specific [3H]Ifenprodil Binding to Recombinant Human NR1a/NR2B Receptors Compared with Native Receptors in Rodent Brain Membranes by Grimwood, Sarah, Richards, Pawel, Murray, Fraser, Harrison, Neil, Wingrove, Peter B., Hutson, Peter H.

“…: We have performed [3H]ifenprodil bindingexperiments under NMDA receptor‐specific assay conditions to provide the firstdetailed characterisation of the…”
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A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-d-aspartate type 2B receptor by Rosahl, Thomas W., Wingrove, Peter B., Hunt, Verity, Fradley, Rosa L., Lawrence, Jason M.K., Heavens, Robert P., Treacey, Patrick, Usala, Marcelo, Macaulay, Alison, Bonnert, Timothy P., Whiting, Paul J., Wafford, Keith A.

“…Selective antagonism of N-methyl-d-aspartate (NMDA) 2B subunit containing receptors has been suggested to have potential therapeutic application for multiple…”
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Mutation at the putative GABAA ion‐channel gate reveals changes in allosteric modulation by Thompson, Sally‐Anne, Smith, Maria Z, Wingrove, Peter B, Whiting, Paul J, Wafford, Keith A

“…We have mutated a conserved leucine in the putative membrane‐spanning domain to serine in human GABAA β2 and investigated the actions of a number of GABAA…”
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The Effects of Training Institution Practice Costs, Quality, and Other Characteristics on Future Practice by Phillips, Robert L., MD, MSPH, Petterson, Stephen M., PhD, Bazemore, Andrew W., MD, MPH, Wingrove, Peter, BS, Puffer, James C., MD

“…Abstract Purpose Medicare beneficiary spending patterns reflect those of the 306 Hospital Referral Regions where physicians train, but whether this holds true…”
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The Modulatory Action of Loreclezole at the γ-Aminobutyric Acid Type a Receptor is Determined by a Single Amino Acid in the β2and β3Subunit by Wingrove, Peter B., Wafford, Keith A., Bain, Corrina, Whiting, Paul J.

“…Type A γ-aminobutyric acid (GABAA) receptors of the mammalian nervous system are a family of ligand-gated ion channels probably formed from the coassembly of…”
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Rural Opioid Use Disorder Treatment Depends on Family Physicians by Wingrove, Peter, BS, Park, Brian, MD, MPH, Bazemore, Andrew, MD, MPH

“…The nation's growing opioid use disorder epidemic disproportionately impacts rural areas, where physicians who can prescribe buprenorphine are scarcest. Among…”
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Identification of amino acid residues responsible for the α5  subunit binding selectivity of L‐655,708, a benzodiazepine binding site ligand at the GABAA receptor by Casula, M. Anna, Bromidge, Frances A., Pillai, Gopalan V., Wingrove, Peter B., Martin, Karine, Maubach, Karen, Seabrook, Guy R., Whiting, Paul J., Hadingham, Karen L.

“…L‐655,708 is a ligand for the benzodiazepine site of the γ‐aminobutyric acid type A (GABAA) receptor that exhibits a 100‐fold higher affinity for α5‐containing…”
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Regional Variation in Primary Care Involvement at the End of Life by Ankuda, Claire K., MD, MPH, Petterson, Stephen M., PhD, Wingrove, Peter, BS, Bazemore, Andrew W., MD, MPH

“…Abstract Purpose Variation in end-of-life care in the United States is frequently driven by the health care system. We assessed the association of primary care…”
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Family Medicine: An Underutilized Resource in Addressing the Opioid Epidemic? by Crothers, Jacob, MD, Petterson, Stephen, PhD, Bazemore, Andrew, MD, MPH, Wingrove, Peter, BS

“…Opioid overdose rates have tripled since 2000, and although overprescribing of opioids by physicians is widely accepted as a causal factor, the physician's…”
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Family Physicians Contribute Significantly to Emergency Care of Medicare Patients in Urban and Suburban Areas by Banks, Gerald, MD, MS, Wingrove, Peter, BS, Petterson, Stephen, PhD, Klink, Kathleen, MD

“…Rural populations rely on physicians trained in primary care to provide emergency services. Less is known about primary care's contribution to emergency…”
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Shifting Sources of U.S. Primary Care Physicians by Lin, Susan X., DrPH, Klink, Kathleen, MD, FAAFP, Wingrove, Peter, BS, Petterson, Stephen, PhD, Bazemore, Andrew, MD, MPH

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Graduates of Teaching Health Centers Are More Likely to Enter Practice in the Primary Care Safety Net by Bazemore, Andrew, MD, MPH, Wingrove, Peter, BS, Petterson, Stephen, PhD, Peterson, Lars, MD, PhD, Raffoul, Melanie, MD, Phillips, Robert L., MD, MSPH

“…The Teaching Health Center Graduate Medical Education (THCGME) program funds new primary care residencies at community health centers caring for the nation's…”
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Mechanism of α-subunit selectivity of benzodiazepine pharmacology at γ-aminobutyric acid type A receptors by Wingrove, Peter B, Safo, Patrick, Wheat, Lola, Thompson, Sally A, Wafford, Keith A, Whiting, Paul J

“…Benzodiazepine pharmacology at the GABA A receptor is dependent on the α and γ subunit isoforms present. Ligands with higher affinity for certain…”
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Identification of amino acid residues responsible for the α5  subunit binding selectivity of L‐655,708, a benzodiazepine binding site ligand at the GABA A receptor by Casula, M. Anna, Bromidge, Frances A., Pillai, Gopalan V., Wingrove, Peter B., Martin, Karine, Maubach, Karen, Seabrook, Guy R., Whiting, Paul J., Hadingham, Karen L.

“…L‐655,708 is a ligand for the benzodiazepine site of the γ‐aminobutyric acid type A (GABA A ) receptor that exhibits a 100‐fold higher affinity for…”
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Identification of amino acid residues responsible for the a5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABAA receptor by CASULA, M. Anna, BROMIDGE, Frances A, PILLAI, Gopalan V, WINGROVE, Peter B, MARTIN, Karine, MAUBACH, Karen, SEABROOK, Guy R, WHITING, Paul J, HADINGHAM, Karen L

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Generation and characterisation of stable cell lines expressing recombinant human N-methyl-D-aspartate receptor subtypes by Grimwood, S, Le Bourdellès, B, Atack, J R, Barton, C, Cockett, W, Cook, S M, Gilbert, E, Hutson, P H, McKernan, R M, Myers, J, Ragan, C I, Wingrove, P B, Whiting, P J

“…Transfection of mouse L(tk-) cells with human N-methyl-D-aspartate (NMDA) receptor subunit cDNAs under the control of a dexamethasone-inducible promoter has…”
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The modulatory action of loreclezole at the (gammma)-aminobutyric acid type A receptor is determined by a single amino acid in the (Beta2) and (Beta3) subunit by Wingrove, Peter B, Wafford, Keith A, Bain, Corrina, Whiting, Paul J

“…A single amino acid in the Beta2 and Beta3 subunit is shown to confer sensitivity to the modulatory action of loreclezole at the gamma-aminobutyric acid type A…”
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