Search Results - "Wingert, Rebecca A"

Little fish, big catch: zebrafish as a model for kidney disease by Poureetezadi, Shahram Jevin, Wingert, Rebecca A

“…The zebrafish, Danio rerio, is a relevant vertebrate model for biomedical research and translational studies because of its broad genetic conservation with…”
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PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator by Chambers, Joseph M, Wingert, Rebecca A

“…Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and…”
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Renal interstitial cells to the rescue by Wesselman, Hannah M, Wingert, Rebecca A

“…The ability of the adult zebrafish to replace damaged nephrons in the kidney depends on renal progenitor cells and renal interstitial cells working closely…”
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Renal stem cells: fact or science fiction? by McCampbell, Kristen K, Wingert, Rebecca A

“…The kidney is widely regarded as an organ without regenerative abilities. However, in recent years this dogma has been challenged on the basis of observations…”
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Antennas of organ morphogenesis: the roles of cilia in vertebrate kidney development by Marra, Amanda N., Li, Yue, Wingert, Rebecca A.

“…Cilia arose early during eukaryotic evolution, and their structural components are highly conserved from the simplest protists to complex metazoan species. In…”
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Zebrafish nephrogenesis is regulated by interactions between retinoic acid, mecom, and Notch signaling by Li, Yue, Cheng, Christina N., Verdun, Valerie A., Wingert, Rebecca A.

“…The zebrafish pronephros provides a conserved model to study kidney development, in particular to delineate the poorly understood processes of how nephron…”
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Identification of adult nephron progenitors capable of kidney regeneration in zebrafish by Diep, Cuong Q., Ma, Dongdong, Deo, Rahul C., Holm, Teresa M., Naylor, Richard W., Arora, Natasha, Wingert, Rebecca A., Bollig, Frank, Djordjevic, Gordana, Lichman, Benjamin, Zhu, Hao, Ikenaga, Takanori, Ono, Fumihito, Englert, Christoph, Cowan, Chad A., Hukriede, Neil A., Handin, Robert I., Davidson, Alan J.

“…Adult kidney regeneration Fish can regenerate nephrons — the functional units of the kidney — following kidney injury, whereas adult mammals lack this ability…”
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The "3Ds" of Growing Kidney Organoids: Advances in Nephron Development, Disease Modeling, and Drug Screening by Chambers, Brooke E, Weaver, Nicole E, Wingert, Rebecca A

“…A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in vitro that undergoes self-organization, recapitulating aspects of…”
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Using zebrafish to study podocyte genesis during kidney development and regeneration by Kroeger Jr, Paul T., Wingert, Rebecca A.

“…SUMMARY During development, vertebrates form a progression of up to three different kidneys that are comprised of functional units termed nephrons. Nephron…”
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Zebrafish as a Model to Study Retinoic Acid Signaling in Development and Disease by Hawkins, Matthew R, Wingert, Rebecca A

“…Retinoic acid (RA) is a metabolite of vitamin A (retinol) that plays various roles in development to influence differentiation, patterning, and organogenesis…”
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Cannabinoid Signaling in Kidney Disease by Arceri, Liana, Nguyen, Thanh Khoa, Gibson, Shannon, Baker, Sophia, Wingert, Rebecca A

“…Endocannabinoid signaling plays crucial roles in human physiology in the function of multiple systems. The two cannabinoid receptors, CB1 and CB2, are cell…”
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ppargc1a controls nephron segmentation during zebrafish embryonic kidney ontogeny by Chambers, Joseph M, Poureetezadi, Shahram Jevin, Addiego, Amanda, Lahne, Manuela, Wingert, Rebecca A

“…Nephron segmentation involves a concert of genetic and molecular signals that are not fully understood. Through a chemical screen, we discovered that…”
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Principles of Zebrafish Nephron Segment Development by Nguyen, Thanh Khoa, Petrikas, Madeline, Chambers, Brooke E, Wingert, Rebecca A

“…Nephrons are the functional units which comprise the kidney. Each nephron contains a number of physiologically unique populations of specialized epithelial…”
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Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish by Drummond, Bridgette E, Ercanbrack, Wesley S, Wingert, Rebecca A

“…Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to…”
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The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros by Wingert, Rebecca A, Selleck, Rori, Yu, Jing, Song, Huai-Dong, Chen, Zhu, Song, Anhua, Zhou, Yi, Thisse, Bernard, Thisse, Christine, McMahon, Andrew P, Davidson, Alan J

“…Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivided into functionally distinct segments, and a collecting duct…”
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gldc Is Essential for Renal Progenitor Patterning during Kidney Development by Weaver, Nicole E, Healy, Allison, Wingert, Rebecca A

“…The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane that is responsible for regulating glycine levels and contributing…”
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Using Zebrafish to Study Multiciliated Cell Development and Disease States by Nguyen, Thanh Khoa, Baker, Sophia, Rodriguez, John-Michael, Arceri, Liana, Wingert, Rebecca A

“…Multiciliated cells (MCCs) serve many important functions, including fluid propulsion and chemo- and mechanosensing. Diseases ranging from rare conditions to…”
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Atlas of Cellular Dynamics during Zebrafish Adult Kidney Regeneration by McCampbell, Kristen K., Wingert, Rebecca A., Springer, Kristin N.

“…The zebrafish is a useful animal model to study the signaling pathways that orchestrate kidney regeneration, as its renal nephrons are simple, yet they…”
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Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney by Wesselman, Hannah M, Gatz, Allison E, Pfaff, Mairead R, Arceri, Liana, Wingert, Rebecca A

“…Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that…”
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Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development by Poureetezadi, Shahram Jevin, Cheng, Christina N, Chambers, Joseph M, Drummond, Bridgette E, Wingert, Rebecca A

“…Kidney formation involves patterning events that induce renal progenitors to form nephrons with an intricate composition of multiple segments. Here, we…”
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