Search Results - "Wingerchuk, Dean M"

Neuromyelitis Spectrum Disorders by Weinshenker, Brian G., MD, Wingerchuk, Dean M., MD

“…Abstract The understanding of neuromyelitis optica spectrum disorder (NMOSD) has evolved substantially since its initial description over a century ago. The…”
Get full text

Multiple Sclerosis: Current and Emerging Disease-Modifying Therapies and Treatment Strategies by Wingerchuk, Dean M., MD, MSc, FRCP(C), Carter, Jonathan L., MD

“…Abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating central nervous system disease that typically strikes young adults, especially women…”
Get full text

MRI of the relevant domain should be performed to confirm whether clinical symptoms represent an attack of NMOSD: Yes by Carnero Contentti, Edgar, Wingerchuk, Dean M

Get full text

Disease-modifying therapies should be stopped in NMOSD patients in remission – Commentary by Wingerchuk, Dean M

Get full text

The emerging relationship between neuromyelitis optica and systemic rheumatologic autoimmune disease by Wingerchuk, Dean M, Weinshenker, Brian G

“…Neuromyelitis optica (NMO) and NMO spectrum disorders (NMOSD) are associated with autoantibodies that target aquaporin-4 and, in many cases, multiple other…”
Get full text

Epidemiology of Neuromyelitis Optica Spectrum Disorder and Its Prevalence and Incidence Worldwide by Hor, Jyh Yung, Asgari, Nasrin, Nakashima, Ichiro, Broadley, Simon A., Leite, M. Isabel, Kissani, Najib, Jacob, Anu, Marignier, Romain, Weinshenker, Brian G., Paul, Friedemann, Pittock, Sean J., Palace, Jacqueline, Wingerchuk, Dean M., Behne, Jacinta M., Yeaman, Michael R., Fujihara, Kazuo

“…Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon inflammatory disease of the central nervous system, manifesting clinically as optic neuritis,…”
Get full text

Smoking: effects on multiple sclerosis susceptibility and disease progression by Wingerchuk, Dean M.

“…Multiple sclerosis (MS) is associated with both genetic and environmental factors that influence disease susceptibility. Exposure to cigarette smoke is…”
Get full text

Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study by Pittock, Sean J, Dr, Lennon, Vanda A, PhD, McKeon, Andrew, MD, Mandrekar, Jay, PhD, Weinshenker, Brian G, MD, Lucchinetti, Claudia F, MD, O'Toole, Orna, MD, Wingerchuk, Dean M, Dr

“…Summary Background Complement activation after binding of an IgG autoantibody to aquaporin 4 (AQP4) is thought to be a major determinant of CNS inflammation…”
Get full text

Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum by Flanagan, Eoin P., Cabre, Philippe, Weinshenker, Brian G., Sauver, Jennifer St, Jacobson, Debra J., Majed, Masoud, Lennon, Vanda A., Lucchinetti, Claudia F., McKeon, Andrew, Matiello, Marcelo, Kale, Nilifur, Wingerchuk, Dean M., Mandrekar, Jay, Sagen, Jessica A., Fryer, James P., Robinson, Angala Borders, Pittock, Sean J.

“…Objective Neuromyelitis optica (NMO) and its spectrum disorders (NMOSD) are inflammatory demyelinating diseases (IDDs) with a specific biomarker,…”
Get full text

Short myelitis lesions in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders by Flanagan, Eoin P, Weinshenker, Brian G, Krecke, Karl N, Lennon, Vanda A, Lucchinetti, Claudia F, McKeon, Andrew, Wingerchuk, Dean M, Shuster, Elizabeth A, Jiao, Yujuan, Horta, Erika S, Pittock, Sean J

“…Short transverse myelitis (STM; <3 vertebral segments) is considered noncharacteristic of neuromyelitis optica (NMO) spectrum disorders (NMOSDs)…”
Get more information

Predictive models in the diagnosis and treatment of autoimmune epilepsy by Dubey, Divyanshu, Singh, Jaysingh, Britton, Jeffrey W., Pittock, Sean J., Flanagan, Eoin P., Lennon, Vanda A., Tillema, Jan‐Mendelt, Wirrell, Elaine, Shin, Cheolsu, So, Elson, Cascino, Gregory D., Wingerchuk, Dean M., Hoerth, Matthew T., Shih, Jerry J., Nickels, Katherine C., McKeon, Andrew

“…Summary Objective To validate predictive models for neural antibody positivity and immunotherapy response in epilepsy. Methods We conducted a retrospective…”
Get full text

Eculizumab monotherapy for NMOSD: Data from PREVENT and its open-label extension by Pittock, Sean J, Fujihara, Kazuo, Palace, Jacqueline, Berthele, Achim, Kim, Ho Jin, Oreja-Guevara, Celia, Nakashima, Ichiro, Levy, Michael, Shang, Shulian, Yountz, Marcus, Miller, Larisa, Armstrong, Róisín, Wingerchuk, Dean M

“…During PREVENT (a phase 3, randomized, double-blind, placebo-controlled, time-to-event study) and its open-label extension (interim analysis), 33 adults with…”
Get full text

The spectrum of neuromyelitis optica by Wingerchuk, Dean M, MD, Lennon, Vanda A, PhD, Lucchinetti, Claudia F, MD, Pittock, Sean J, MD, Weinshenker, Brian G, MD

“…Summary Neuromyelitis optica (also known as Devic's disease) is an idiopathic, severe, demyelinating disease of the central nervous system that preferentially…”
Get full text

Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial by Voskuhl, Rhonda R, Prof, Wang, HeJing, MD, Wu, T C Jackson, MD, Sicotte, Nancy L, MD, Nakamura, Kunio, PhD, Kurth, Florian, PhD, Itoh, Noriko, MS, Bardens, Jenny, RN, Bernard, Jacqueline T, MD, Corboy, John R, Prof, Cross, Anne H, Prof, Dhib-Jalbut, Suhayl, Prof, Ford, Corey C, Prof, Frohman, Elliot M, Prof, Giesser, Barbara, Prof, Jacobs, Dina, MD, Kasper, Lloyd H, Prof, Lynch, Sharon, Prof, Parry, Gareth, Prof, Racke, Michael K, Prof, Reder, Anthony T, Prof, Rose, John, Prof, Wingerchuk, Dean M, Prof, MacKenzie-Graham, Allan J, PhD, Arnold, Douglas L, Prof, Tseng, Chi Hong, PhD, Elashoff, Robert, Prof

“…Summary Background Relapses of multiple sclerosis decrease during pregnancy, when the hormone estriol is increased. Estriol treatment is anti-inflammatory and…”
Get full text

Updated estimate of AQP4-IgG serostatus and disability outcome in neuromyelitis optica by Jiao, Yujuan, Fryer, James P., Lennon, Vanda A., Jenkins, Sarah M., Quek, Amy M.L., Smith, Carin Y., McKeon, Andrew, Costanzi, Chiara, Iorio, Raffaele, Weinshenker, Brian G., Wingerchuk, Dean M., Shuster, Elizabeth A., Lucchinetti, Claudia F., Pittock, Sean J.

“…OBJECTIVE:To 1) determine, using contemporary recombinant antigen–based assays, the aquaporin-4 (AQP4)–immunoglobulin G (IgG) detection rate in sequential sera…”
Get full text

Aquaporin-4 serostatus does not predict response to immunotherapy in neuromyelitis optica spectrum disorders by Mealy, Maureen A, Kim, Su-Hyun, Schmidt, Felix, López, Reydmar, Jimenez Arango, Jorge A, Paul, Friedemann, Wingerchuk, Dean M, Greenberg, Benjamin M, Kim, Ho Jin, Levy, Michael

“…Background: Debate exists about whether neuromyelitis optica spectrum disorder seronegative disease represents the same immune-mediated attack on astrocytic…”
Get full text

The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations by Valencia-Sanchez, Cristina, Goodman, Brent P, Carter, Jonathan L, Wingerchuk, Dean M

“…Diverse acute neurological injuries may cause acute cardiopulmonary events including neurogenic pulmonary edema (NPE) and neurogenic stunned myocardium (NSM)…”
Get full text

A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis by Lennon, Vanda A, Wingerchuk, Dean M, Kryzer, Thomas J, Pittock, Sean J, Lucchinetti, Claudia F, Fujihara, Kazuo, Nakashima, Ichiro, Weinshenker, Brian G

“…Neuromyelitis optica is an inflammatory demyelinating disease with generally poor prognosis that selectively targets optic nerves and spinal cord. It is…”
Get full text

Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis by Weinshenker, Brian G., Wingerchuk, Dean M., Vukusic, Sandra, Linbo, Linda, Pittock, Sean J., Lucchinetti, Claudia F., Lennon, Vanda A.

“…Objective We investigated whether neuromyelitis optica (NMO) IgG seropositivity at the initial presentation of longitudinally extensive transverse myelitis…”
Get full text

Neuromyelitis optica spectrum disorder diagnostic criteria: Sensitivity and specificity are both important by Wingerchuk, Dean M, Weinshenker, Brian G

Get full text