Search Results - "Winger, Ryan C"

Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier by Winger, Ryan C, Koblinski, Jennifer E, Kanda, Takashi, Ransohoff, Richard M, Muller, William A

“…Leukocyte transendothelial migration (TEM; diapedesis) is a critical event in immune surveillance and inflammation. Most TEM occurs at endothelial cell borders…”
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Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration by Watson, Richard L, Buck, Jochen, Levin, Lonny R, Winger, Ryan C, Wang, Jing, Arase, Hisashi, Muller, William A

“…CD99 is a critical regulator of leukocyte transendothelial migration (TEM). How CD99 signals during this process remains unknown. We show that during TEM,…”
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Longitudinal study of immunity to SARS‐CoV2 in ocrelizumab‐treated MS patients up to 2 years after COVID‐19 vaccination by Kister, Ilya, Curtin, Ryan, Piquet, Amanda L., Borko, Tyler, Pei, Jinglan, Banbury, Barbara L, Bacon, Tamar E., Kim, Angie, Tuen, Michael, Velmurugu, Yogambigai, Nyovanie, Samantha, Selva, Sean, Samanovic, Marie I., Mulligan, Mark J., Patskovsky, Yury, Priest, Jessica, Cabatingan, Mark, Winger, Ryan C., Krogsgaard, Michelle, Silverman, Gregg J.

“…Objectives (1) To plot the trajectory of humoral and cellular immune responses to the primary (two‐dose) COVID‐19 mRNA series and the third/booster dose in…”
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Hybrid and vaccine‐induced immunity against SAR‐CoV‐2 in MS patients on different disease‐modifying therapies by Kister, Ilya, Curtin, Ryan, Pei, Jinglan, Perdomo, Katherine, Bacon, Tamar E., Voloshyna, Iryna, Kim, Joseph, Tardio, Ethan, Velmurugu, Yogambigai, Nyovanie, Samantha, Valeria Calderon, Andrea, Dibba, Fatoumatta, Stanzin, Igda, Samanovic, Marie I., Raut, Pranil, Raposo, Catarina, Priest, Jessica, Cabatingan, Mark, Winger, Ryan C., Mulligan, Mark J., Patskovsky, Yury, Silverman, Gregg J., Krogsgaard, Michelle

“…Objective To compare “hybrid immunity” (prior COVID‐19 infection plus vaccination) and post‐vaccination immunity to SARS CoV‐2 in MS patients on different…”
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Safety and patient experience with at‐home infusion of ocrelizumab for multiple sclerosis by Barrera, Britney, Simpson, Haley, Engebretson, Eric, Sillau, Stefan, Valdez, Brooke, Parra‐González, José, Winger, Ryan C., Epperson, Lou Anne, Banks, Ashley, Pierce, Kathryn, Spotts, Melanie, O'Gean, Katie, Alvarez, Enrique, Gross, Robert, Piquet, Amanda L., Schreiner, Teri, Corboy, John R., Pei, Jinglan, Vollmer, Timothy L., Nair, Kavita V.

“…Objective This study aimed to evaluate safety (infusion‐related reactions [IRRs]) and patient satisfaction (patient‐reported outcomes [PROs]) for at‐home…”
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Antibodies in multiple sclerosis oligoclonal bands target debris by Winger, Ryan C., Zamvil, Scott S.

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Evolution of atrophied T2 lesion volume in primary-progressive multiple sclerosis: results from the phase 3 ORATORIO study by Zivadinov, Robert, Pei, Jinglan, Clayton, David, Goldman, Donna E, Winger, Ryan C, Cabatingan, Mark S, Dwyer, Michael G, Bergsland, Niels

“…BackgroundAtrophied T2-lesion volume (aT2-LV) is an exploratory imaging marker in multiple sclerosis (MS) reflecting the volume of lesions subsumed into…”
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Cellular and Humoral Immunity to SARS‐CoV‐2 Infection in Multiple Sclerosis Patients on Ocrelizumab and Other Disease‐Modifying Therapies: A Multi‐Ethnic Observational Study by Kister, Ilya, Patskovsky, Yury, Curtin, Ryan, Pei, Jinglan, Perdomo, Katherine, Rimler, Zoe, Voloshyna, Iryna, Samanovic, Marie I., Cornelius, Amber R., Velmurugu, Yogambigai, Nyovanie, Samantha, Kim, Joseph J., Tardio, Ethan, Bacon, Tamar E., Zhovtis Ryerson, Lana, Raut, Pranil, Pedotti, Rosetta, Hawker, Kathleen, Raposo, Catarina, Priest, Jessica, Cabatingan, Mark, Winger, Ryan C., Mulligan, Mark J., Krogsgaard, Michelle, Silverman, Gregg J.

“…Objective The objective of this study was to determine the impact of multiple sclerosis (MS) disease‐modifying therapies (DMTs) on the development of cellular…”
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Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity by Shinoda, Koji, Li, Rui, Rezk, Ayman, Mexhitaj, Ina, Patterson, Kristina R, Kakara, Mihir, Zuroff, Leah, Bennett, Jeffrey L, von Büdingen, H-Christian, Carruthers, Robert, Edwards, Keith R, Fallis, Robert, Giacomini, Paul S, Greenberg, Benjamin M, Hafler, David A, Ionete, Carolina, Kaunzner, Ulrike W, Lock, Christopher B, Longbrake, Erin E, Pardo, Gabriel, Piehl, Fredrik, Weber, Martin S, Ziemssen, Tjalf, Jacobs, Dina, Gelfand, Jeffrey M, Cross, Anne H, Cameron, Briana, Musch, Bruno, Winger, Ryan C, Jia, Xiaoming, Harp, Christopher T, Herman, Ann, Bar-Or, Amit

“…A small proportion of multiple sclerosis (MS) patients develop new disease activity soon after starting anti-CD20 therapy. This activity does not recur with…”
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Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4 by Sagan, Sharon A., Winger, Ryan C., Cruz-Herranz, Andrés, Nelson, Patricia A., Hagberg, Sarah, Miller, Corey N., Spencer, Collin M., Ho, Peggy P., Bennett, Jeffrey L., Levy, Michael, Levin, Marc H., Verkman, Alan S., Steinman, Lawrence, Green, Ari J., Anderson, Mark S., Sobel, Raymond A., Zamvil, Scott S.

“…Aquaporin-4 (AQP4)-specific T cells are expanded in neuromyelitis optica (NMO) patients and exhibit Th17 polarization. However, their pathogenic role in CNS…”
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Your nose knows how to target brain inflammation by Winger, Ryan C, Zamvil, Scott S

“…This scientific commentary refers to 'IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation', by…”
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Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease by Winger, Ryan C, Harp, Christopher T, Chiang, Ming-Yi, Sullivan, David P, Watson, Richard L, Weber, Evan W, Podojil, Joseph R, Miller, Stephen D, Muller, William A

“…Leukocyte trafficking into the CNS is a prominent feature driving the immunopathogenesis of multiple sclerosis and its animal model, experimental autoimmune…”
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The CELLO trial: Protocol of a planned phase 4 study to assess the efficacy of Ocrelizumab in patients with radiologically isolated syndrome by Longbrake, Erin E., Hua, Le H., Mowry, Ellen M., Gauthier, Susan A., Alvarez, Enrique, Cross, Anne H., Pei, Jinglan, Priest, Jessica, Raposo, Catarina, Hafler, David A., Winger, Ryan C.

“…•Neurologic damage usually begins well before MS can be diagnosed.•Many radiologically isolated syndrome (RIS) patients go on to develop MS.•The CELLO trial…”
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TGF-beta enhances effector Th1 cell activation but promotes self-regulation via IL-10 by Huss, David J, Winger, Ryan C, Peng, Haiyan, Yang, Yuhong, Racke, Michael K, Lovett-Racke, Amy E

“…Myelin-specific effector Th1 cells are able to perpetuate CNS inflammation in experimental autoimmune encephalomyelitis, an animal model representative of…”
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TGF‐β signaling via Smad4 drives IL‐10 production in effector Th1 cells and reduces T‐cell trafficking in EAE by Huss, David J., Winger, Ryan C., Cox, Gina Mavrikis, Guerau‐de‐Arellano, Mireia, Yang, Yuhong, Racke, Michael K., Lovett‐Racke, Amy E.

“…Effector Th1 cells perpetuate inflammatory damage in a number of autoimmune diseases, including MS and its animal model EAE. Recently, a self‐regulatory…”
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CNS accumulation of regulatory B cells is VLA-4-dependent by Lehmann-Horn, Klaus, Sagan, Sharon A, Winger, Ryan C, Spencer, Collin M, Bernard, Claude C.A, Sobel, Raymond A, Zamvil, Scott S

“…OBJECTIVE:To investigate the role of very late antigen-4 (VLA-4) on regulatory B cells (Breg) in CNS autoimmune disease. METHODS:Experimental autoimmune…”
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The FLUENT study design: investigating immune cell subset and neurofilament changes in patients with relapsing multiple sclerosis treated with fingolimod by Cohen, Jeffrey A, Bar-Or, Amit, Cree, Bruce A C, Mao-Draayer, Yang, Han, May H, Singer, Barry, Jannu, Ann, Kolodny, Scott, Meng, Xiangyi, Winger, Ryan C

“…Background Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of patients with relapsing forms of multiple sclerosis (RMS)…”
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Multi-Omic characterization of the effects of Ocrelizumab in patients with relapsing-remitting multiple sclerosis by Kornilov, Sergey A., Price, Nathan D., Gelinas, Richard, Acosta, Juan, Brunkow, Mary E., Gervasi-Follmar, Tiffany, Winger, Ryan C., Aldershoff, Dmitri, Lausted, Christopher, Troisch, Pamela, Smith, Brett, Heath, James R., Repovic, Pavle, Cohan, Stanley, Magis, Andrew T.

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Humoral and Cellular Responses to SARS-CoV-2 Vaccines in MS Patients on Ocrelizumab and Other Disease-modifying Therapies: A Prospective Study From NYU Multiple Sclerosis Care Center (P1-1.Virtual) by Kister, Ilya, Patskovsky, Yury, Curtin, Ryan, Voloshyna, Iryna, Perdomo, Katherine, Rimler, Zoe, Pei, Jinglan, Ferstler, Nicole, Velmurugu, Yogambigai, Nyovanie, Samantha, Mulligan, Mark J., Kim, Joseph, Tardio, Ethan, Bacon, Tamar, Ryerson, Lana Zhovtis, Samanovic-Golden, Marie, Cornelius, Amber, Raposo, Catarina, Priest, Jessica, Winger, Ryan C., Krogsgaard, Michelle, Silverman, Gregg J.

“…Abstract only…”
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Pathway of leukocyte transendothelial migration across an in vitro human blood brain barrier model by Winger, Ryan C., Koblinski, Jennifer E., Muller, William A.

“…Abstract only Leukocyte transendothelial migration (TEM) can occur at endothelial junctions (paracellular) or directly through the endothelial cell body…”
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