Search Results - "Winge, Dennis R."

Copper metallochaperones by Robinson, Nigel J, Winge, Dennis R

“…The current state of knowledge on how copper metallochaperones support the maturation of cuproproteins is reviewed. Copper is needed within mitochondria to…”
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Sealing the Mitochondrial Respirasome by Winge, Dennis R.

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Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis by Hughes, Casey E., Coody, Troy K., Jeong, Mi-Young, Berg, Jordan A., Winge, Dennis R., Hughes, Adam L.

“…Mitochondria and lysosomes are functionally linked, and their interdependent decline is a hallmark of aging and disease. Despite the long-standing connection…”
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The LYR Factors SDHAF1 and SDHAF3 Mediate Maturation of the Iron-Sulfur Subunit of Succinate Dehydrogenase by Na, Un, Yu, Wendou, Cox, James, Bricker, Daniel K., Brockmann, Knut, Rutter, Jared, Thummel, Carl S., Winge, Dennis R.

“…Disorders arising from impaired assembly of succinate dehydrogenase (SDH) result in a myriad of pathologies, consistent with its unique role in linking the…”
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Metal Acquisition and Availability in the Mitochondria by Atkinson, Aaron, Winge, Dennis R

“…The metal reactions resulting during metalloprotein biosynthesis through different channels and bioavailable metal ion pools in mitochondria are discussed…”
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Structure, function, and assembly of heme centers in mitochondrial respiratory complexes by Kim, Hyung J., Khalimonchuk, Oleh, Smith, Pamela M., Winge, Dennis R.

“…The sequential flow of electrons in the respiratory chain, from a low reduction potential substrate to O2, is mediated by protein-bound redox cofactors. In…”
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A Novel Role for Copper in Ras/Mitogen-Activated Protein Kinase Signaling by Turski, Michelle L., Brady, Donita C., Kim, Hyung J., Kim, Byung-Eun, Nose, Yasuhiro, Counter, Christopher M., Winge, Dennis R., Thiele, Dennis J.

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SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma by Hao, Huai-Xiang, Khalimonchuk, Oleh, Schraders, Margit, Dephoure, Noah, Bayley, Jean-Pierre, Kunst, Henricus, Devilee, Peter, Cremers, Cor W.R.J, Schiffman, Joshua D, Bentz, Brandon G, Gygi, Steven P, Winge, Dennis R, Kremer, Hannie, Rutter, Jared

“…Mammalian mitochondria contain about 1100 proteins, nearly 300 of which are uncharacterized. Given the well-established role of mitochondrial defects in human…”
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Role of Nfu1 and Bol3 in iron-sulfur cluster transfer to mitochondrial clients by Melber, Andrew, Na, Un, Vashisht, Ajay, Weiler, Benjamin D, Lill, Roland, Wohlschlegel, James A, Winge, Dennis R

“…Iron-sulfur (Fe-S) clusters are essential for many cellular processes, ranging from aerobic respiration, metabolite biosynthesis, ribosome assembly and DNA…”
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The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis by Van Vranken, Jonathan G, Jeong, Mi-Young, Wei, Peng, Chen, Yu-Chan, Gygi, Steven P, Winge, Dennis R, Rutter, Jared

“…Mitochondrial fatty acid synthesis (FASII) and iron sulfur cluster (FeS) biogenesis are both vital biosynthetic processes within mitochondria. In this study,…”
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N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization by Freibert, Sven-A., Boniecki, Michal T., Stümpfig, Claudia, Schulz, Vinzent, Krapoth, Nils, Winge, Dennis R., Mühlenhoff, Ulrich, Stehling, Oliver, Cygler, Miroslaw, Lill, Roland

“…Synthesis of iron-sulfur (Fe/S) clusters in living cells requires scaffold proteins for both facile synthesis and subsequent transfer of clusters to target…”
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Emerging concepts in the flavinylation of succinate dehydrogenase by Kim, Hyung J., Winge, Dennis R.

“…The Succinate Dehydrogenase (SDH) heterotetrameric complex catalyzes the oxidation of succinate to fumarate in the tricarboxylic acid (TCA) cycle and in the…”
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Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper ion entry site by Fetherolf, Morgan M., Boyd, Stefanie D., Taylor, Alexander B., Kim, Hee Jong, Wohlschlegel, James A., Blackburn, Ninian J., Hart, P. John, Winge, Dennis R., Winkler, Duane D.

“…Metallochaperones are a diverse family of trafficking molecules that provide metal ions to protein targets for use as cofactors. The copper chaperone for…”
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Copper trafficking to the mitochondrion and assembly of copper metalloenzymes by Cobine, Paul A., Pierrel, Fabien, Winge, Dennis R.

“…Copper is required within the mitochondrion for the function of two metalloenzymes, cytochrome c oxidase (CcO) and superoxide dismutase (Sod1). Copper…”
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Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria by Nowinski, Sara M, Solmonson, Ashley, Rusin, Scott F, Maschek, J Alan, Bensard, Claire L, Fogarty, Sarah, Jeong, Mi-Young, Lettlova, Sandra, Berg, Jordan A, Morgan, Jeffrey T, Ouyang, Yeyun, Naylor, Bradley C, Paulo, Joao A, Funai, Katsuhiko, Cox, James E, Gygi, Steven P, Winge, Dennis R, DeBerardinis, Ralph J, Rutter, Jared

“…Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty acid synthase, FASN) and one in the mitochondria (mtFAS). In…”
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LYRM7/MZM1L is a UQCRFS1 chaperone involved in the last steps of mitochondrial Complex III assembly in human cells by Sánchez, Ester, Lobo, Teresa, Fox, Jennifer L., Zeviani, Massimo, Winge, Dennis R., Fernández-Vizarra, Erika

“…The mammalian Complex III (CIII) assembly process is yet to be completely understood. There is still a lack in understanding of how the structural subunits are…”
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An extracellular histidine-containing motif in the zinc transporter ZIP4 plays a role in zinc sensing and zinc-induced endocytosis in mammalian cells by Chun, Haarin, Korolnek, Tamara, Lee, Chul-Jin, Coyne, H. Jerome, Winge, Dennis R., Kim, Byung-Eun, Petris, Michael J.

“…Zinc is an essential trace element that serves as a cofactor for enzymes in critical biochemical processes and also plays a structural role in numerous…”
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Evidence for a Pro-oxidant Intermediate in the Assembly of Cytochrome Oxidase by Khalimonchuk, Oleh, Bird, Amanda, Winge, Dennis R.

“…The hydrogen peroxide sensitivity of cells lacking two proteins, Sco1 and Cox11, important in the assembly of cytochrome c oxidase (CcO), is shown to arise…”
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Oxygen-dependent activation of Cu,Zn-superoxide dismutase-1 by Fetherolf, Morgan, Boyd, Stefanie D, Winkler, Duane D, Winge, Dennis R

“…Copper zinc superoxide dismutase (Sod1) is a critical enzyme in limiting reactive oxygen species in both the cytosol and the mitochondrial intermembrane space…”
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Role of Glutaredoxin-3 and Glutaredoxin-4 in the Iron Regulation of the Aft1 Transcriptional Activator in Saccharomyces cerevisiae by Ojeda, Luis, Keller, Greg, Muhlenhoff, Ulrich, Rutherford, Julian C., Lill, Roland, Winge, Dennis R.

“…The transcription factors Aft1 and Aft2 from Saccharomyces cerevisiae regulate the expression of genes involved in iron homeostasis. These factors induce the…”
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