Search Results - "Wingate, Richard J.T."

The rhombic lip and early cerebellar development by Wingate, Richard J.T

“…Recent studies have transformed our understanding of the embryonic rhombic lip by revealing the inductive cues, regional origins and guidance molecules that…”
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The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non-teleost ray-finned fish by Butts, Thomas, Modrell, Melinda S., Baker, Clare V.H., Wingate, Richard J.T.

“…SUMMARY The cerebellum represents one of the most morphologically variable structures in the vertebrate brain. To shed light on its evolutionary history, we…”
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Development of the cerebellum: simple steps to make a 'little brain' by Butts, Thomas, Green, Mary J, Wingate, Richard J T

“…The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly. Increasing interest in the cerebellum as a participant in higher…”
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Consensus Paper: Cerebellar Development by Leto, Ketty, Arancillo, Marife, Becker, Esther B. E., Buffo, Annalisa, Chiang, Chin, Ding, Baojin, Dobyns, William B., Dusart, Isabelle, Haldipur, Parthiv, Hatten, Mary E., Hoshino, Mikio, Joyner, Alexandra L., Kano, Masanobu, Kilpatrick, Daniel L., Koibuchi, Noriyuki, Marino, Silvia, Martinez, Salvador, Millen, Kathleen J., Millner, Thomas O., Miyata, Takaki, Parmigiani, Elena, Schilling, Karl, Sekerková, Gabriella, Sillitoe, Roy V., Sotelo, Constantino, Uesaka, Naofumi, Wefers, Annika, Wingate, Richard J. T., Hawkes, Richard

“…The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main…”
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Mitotic granule cell precursors undergo highly dynamic morphological transitions throughout the external germinal layer of the chick cerebellum by Hanzel, Michalina, Rook, Victoria, Wingate, Richard J. T.

“…The developing cerebellum of amniotes is characterised by a unique, transient, secondary proliferation zone: the external germinal layer (EGL). The EGL is…”
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Sox14 Is Required for a Specific Subset of Cerebello-Olivary Projections by Prekop, Hong-Ting, Kroiss, Anna, Rook, Victoria, Zagoraiou, Laskaro, Jessell, Thomas M, Fernandes, Cathy, Delogu, Alessio, Wingate, Richard J T

“…We identify as an exclusive marker of inhibitory projection neurons in the lateral and interposed, but not the medial, cerebellar nuclei. neurons make up ∼80%…”
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Conserved and divergent development of brainstem vestibular and auditory nuclei by Lipovsek, Marcela, Wingate, Richard Jt

“…Vestibular function was established early in vertebrates and has remained, for the most part, unchanged. In contrast, each group of tetrapods underwent…”
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Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors by Hanzel, Michalina, Wingate, Richard J.T., Butts, Thomas

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Transit amplification in the amniote cerebellum evolved via a heterochronic shift in NeuroD1 expression by Butts, Thomas, Hanzel, Michalina, Wingate, Richard J T

“…The cerebellum has evolved elaborate foliation in the amniote lineage as a consequence of extensive Atoh1-mediated transit amplification in an external…”
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Absence of an External Germinal Layer in Zebrafish and Shark Reveals a Distinct, Anamniote Ground Plan of Cerebellum Development by Chaplin, Natalie, Tendeng, Christian, Wingate, Richard J. T

“…The granule cell layer of the cerebellum comprises the largest population of neurons in the vertebrate CNS. In amniotes, its precursors undergo a unique phase…”
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MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development by Delbaere, Joke, Vancamp, Pieter, Van Herck, Stijn L J, Bourgeois, Nele M A, Green, Mary J, Wingate, Richard J T, Darras, Veerle M

“…Inactivating mutations in the human SLC16A2 gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in the…”
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The roof plate boundary is a bi-directional organiser of dorsal neural tube and choroid plexus development by Broom, Emma R, Gilthorpe, Jonathan D, Butts, Thomas, Campo-Paysaa, Florent, Wingate, Richard J T

“…The roof plate is a signalling centre positioned at the dorsal midline of the central nervous system and generates dorsalising morphogenic signals along the…”
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Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1 by Green, Mary J, Myat, Anna M, Emmenegger, Brian A, Wechsler-Reya, Robert J, Wilson, Leigh J, Wingate, Richard J T

“…The rhombic lip gives rise to neuronal populations that contribute to cerebellar, proprioceptive and interoceptive networks. Cell production depends on the…”
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Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors by Hanzel, Michalina, Wingate, Richard J T, Butts, Thomas

“…The cerebellar external granule layer (EGL) is the site of the largest transit amplification in the developing brain, and an excellent model for studying…”
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Developmental origins of diversity in cerebellar output nuclei by Green, Mary J, Wingate, Richard J T

“…The functional integration of the cerebellum into a number of different neural systems is governed by the connection of its output axons. In amniotes, the…”
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The role of the rhombic lip in avian cerebellum development by Wingate, R J, Hatten, M E

“…We have used a combination of quail-chick fate-mapping techniques and dye labelling to investigate the development of the avian cerebellum. Using Hoxa2 as a…”
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Mosaic Expression of Thyroid Hormone Regulatory Genes Defines Cell Type-Specific Dependency in the Developing Chicken Cerebellum by Delbaere, Joke, Van Herck, Stijn L. J., Bourgeois, Nele M. A., Vancamp, Pieter, Yang, Shuo, Wingate, Richard J. T., Darras, Veerle M.

“…The cerebellum is a morphologically unique brain structure that requires thyroid hormones (THs) for the correct coordination of key cellular events driving its…”
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Temporal identity transition in the avian cerebellar rhombic lip by Wilson, Leigh J., Wingate, Richard J.T.

“…The rhombic lip is a discrete strip of neuroepithelium bordering the roofplate of the fourth ventricle, which gives rise to a defined sequence of migratory…”
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Can Clues from Evolution Unlock the Molecular Development of the Cerebellum by Butts, Thomas, Chaplin, Natalie, Wingate, Richard J. T

“…The cerebellum sits at the rostral end of the vertebrate hindbrain and is responsible for sensory and motor integration. Owing to its relatively simple…”
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The migration of cerebellar rhombic lip derivatives by Gilthorpe, Jonathan D, Papantoniou, Elli-Kalliopi, Chédotal, Alain, Lumsden, Andrew, Wingate, Richard J T

“…We have used cell labelling, co-culture and time-lapse confocal microscopy to investigate tangential neuronal migration from the rhombic lip. Cerebellar…”
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