Search Results - "Wingate, Richard J T"

Development of the cerebellum: simple steps to make a 'little brain' by Butts, Thomas, Green, Mary J, Wingate, Richard J T

“…The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly. Increasing interest in the cerebellum as a participant in higher…”
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Consensus Paper: Cerebellar Development by Leto, Ketty, Arancillo, Marife, Becker, Esther B. E., Buffo, Annalisa, Chiang, Chin, Ding, Baojin, Dobyns, William B., Dusart, Isabelle, Haldipur, Parthiv, Hatten, Mary E., Hoshino, Mikio, Joyner, Alexandra L., Kano, Masanobu, Kilpatrick, Daniel L., Koibuchi, Noriyuki, Marino, Silvia, Martinez, Salvador, Millen, Kathleen J., Millner, Thomas O., Miyata, Takaki, Parmigiani, Elena, Schilling, Karl, Sekerková, Gabriella, Sillitoe, Roy V., Sotelo, Constantino, Uesaka, Naofumi, Wefers, Annika, Wingate, Richard J. T., Hawkes, Richard

“…The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main…”
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Absence of an External Germinal Layer in Zebrafish and Shark Reveals a Distinct, Anamniote Ground Plan of Cerebellum Development by Chaplin, Natalie, Tendeng, Christian, Wingate, Richard J. T

“…The granule cell layer of the cerebellum comprises the largest population of neurons in the vertebrate CNS. In amniotes, its precursors undergo a unique phase…”
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MCT8 deficiency in Purkinje cells disrupts embryonic chicken cerebellar development by Delbaere, Joke, Vancamp, Pieter, Van Herck, Stijn L J, Bourgeois, Nele M A, Green, Mary J, Wingate, Richard J T, Darras, Veerle M

“…Inactivating mutations in the human SLC16A2 gene encoding the thyroid hormone transporter monocarboxylate transporter 8 (MCT8) result in the…”
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Transit amplification in the amniote cerebellum evolved via a heterochronic shift in NeuroD1 expression by Butts, Thomas, Hanzel, Michalina, Wingate, Richard J T

“…The cerebellum has evolved elaborate foliation in the amniote lineage as a consequence of extensive Atoh1-mediated transit amplification in an external…”
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Can Clues from Evolution Unlock the Molecular Development of the Cerebellum by Butts, Thomas, Chaplin, Natalie, Wingate, Richard J. T

“…The cerebellum sits at the rostral end of the vertebrate hindbrain and is responsible for sensory and motor integration. Owing to its relatively simple…”
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Mitotic granule cell precursors undergo highly dynamic morphological transitions throughout the external germinal layer of the chick cerebellum by Hanzel, Michalina, Rook, Victoria, Wingate, Richard J. T.

“…The developing cerebellum of amniotes is characterised by a unique, transient, secondary proliferation zone: the external germinal layer (EGL). The EGL is…”
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Homeotic Transformation of Rhombomere Identity after Localized Hoxb1 Misexpression by Bell, Esther, Richard J. T. Wingate, Lumsden, Andrew

“…Segmentation of the hindbrain and branchial region is a conserved feature of head development, involving the nested expression of Hox genes. Although it is…”
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Mosaic Expression of Thyroid Hormone Regulatory Genes Defines Cell Type-Specific Dependency in the Developing Chicken Cerebellum by Delbaere, Joke, Van Herck, Stijn L. J., Bourgeois, Nele M. A., Vancamp, Pieter, Yang, Shuo, Wingate, Richard J. T., Darras, Veerle M.

“…The cerebellum is a morphologically unique brain structure that requires thyroid hormones (THs) for the correct coordination of key cellular events driving its…”
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Sox14 Is Required for a Specific Subset of Cerebello-Olivary Projections by Prekop, Hong-Ting, Kroiss, Anna, Rook, Victoria, Zagoraiou, Laskaro, Jessell, Thomas M, Fernandes, Cathy, Delogu, Alessio, Wingate, Richard J T

“…We identify as an exclusive marker of inhibitory projection neurons in the lateral and interposed, but not the medial, cerebellar nuclei. neurons make up ∼80%…”
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Independently specified Atoh1 domains define novel developmental compartments in rhombomere 1 by Green, Mary J, Myat, Anna M, Emmenegger, Brian A, Wechsler-Reya, Robert J, Wilson, Leigh J, Wingate, Richard J T

“…The rhombic lip gives rise to neuronal populations that contribute to cerebellar, proprioceptive and interoceptive networks. Cell production depends on the…”
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Conserved and divergent development of brainstem vestibular and auditory nuclei by Lipovsek, Marcela, Wingate, Richard Jt

“…Vestibular function was established early in vertebrates and has remained, for the most part, unchanged. In contrast, each group of tetrapods underwent…”
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The roof plate boundary is a bi-directional organiser of dorsal neural tube and choroid plexus development by Broom, Emma R, Gilthorpe, Jonathan D, Butts, Thomas, Campo-Paysaa, Florent, Wingate, Richard J T

“…The roof plate is a signalling centre positioned at the dorsal midline of the central nervous system and generates dorsalising morphogenic signals along the…”
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Developmental origins of diversity in cerebellar output nuclei by Green, Mary J, Wingate, Richard J T

“…The functional integration of the cerebellum into a number of different neural systems is governed by the connection of its output axons. In amniotes, the…”
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The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non-teleost ray-finned fish by Butts, Thomas, Modrell, Melinda S., Baker, Clare V.H., Wingate, Richard J.T.

“…SUMMARY The cerebellum represents one of the most morphologically variable structures in the vertebrate brain. To shed light on its evolutionary history, we…”
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Segmental identity and cerebellar granule cell induction in rhombomere 1 by Eddison, Mark, Toole, Leah, Bell, Esther, Wingate, Richard J T

“…Cerebellar granule cell precursors are specifically generated within the hindbrain segment, rhombomere 1, which is bounded rostrally by the midbrain/hindbrain…”
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Generation of the squamous epithelial roof of the 4th ventricle by Campo-Paysaa, Florent, Clarke, Jonathan DW, Wingate, Richard JT

“…We use the transparency of zebrafish embryos to reveal the de novo generation of a simple squamous epithelium and identify the cellular architecture in the…”
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The migration of cerebellar rhombic lip derivatives by Gilthorpe, Jonathan D, Papantoniou, Elli-Kalliopi, Chédotal, Alain, Lumsden, Andrew, Wingate, Richard J T

“…We have used cell labelling, co-culture and time-lapse confocal microscopy to investigate tangential neuronal migration from the rhombic lip. Cerebellar…”
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Retinoic acid is a potential dorsalising signal in the late embryonic chick hindbrain by Wilson, Leigh J, Myat, Anna, Sharma, Aadhar, Maden, Malcolm, Wingate, Richard J T

“…Human retinoic acid teratogenesis results in malformations of dorsally derived hindbrain structures such as the cerebellum, noradrenergic hindbrain neurons and…”
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Ex Vivo Culture of Chick Cerebellar Slices and Spatially Targeted Electroporation of Granule Cell Precursors by Hanzel, Michalina, Wingate, Richard J T, Butts, Thomas

“…The cerebellar external granule layer (EGL) is the site of the largest transit amplification in the developing brain, and an excellent model for studying…”
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