Search Results - "Winfrey, P."

Production of Selenoprotein P (Sepp1) by Hepatocytes Is Central to Selenium Homeostasis by Hill, Kristina E., Wu, Sen, Motley, Amy K., Stevenson, Teri D., Winfrey, Virginia P., Capecchi, Mario R., Atkins, John F., Burk, Raymond F.

“…Sepp1 is a widely expressed extracellular protein that in humans and mice contains 10 selenocysteine residues in its primary structure. Extra-hepatic tissues…”
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The role of citizen science in addressing grand challenges in food and agriculture research by Ryan, S F, Adamson, N L, Aktipis, A, Andersen, L K, Austin, R, Barnes, L, Beasley, M R, Bedell, K D, Briggs, S, Chapman, B, Cooper, C B, Corn, J O, Creamer, N G, Delborne, J A, Domenico, P, Driscoll, E, Goodwin, J, Hjarding, A, Hulbert, J M, Isard, S, Just, M G, Kar Gupta, K, López-Uribe, M M, O'Sullivan, J, Landis, E A, Madden, A A, McKenney, E A, Nichols, L M, Reading, B J, Russell, S, Sengupta, N, Shapiro, L R, Shell, L K, Sheard, J K, Shoemaker, D D, Sorger, D M, Starling, C, Thakur, S, Vatsavai, R R, Weinstein, M, Winfrey, P, Dunn, R R

“…The power of citizen science to contribute to both science and society is gaining increased recognition, particularly in physics and biology. Although there is…”
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Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells by Olson, Gary E., Winfrey, Virginia P., Hill, Kristina E., Burk, Raymond F.

“…Selenoprotein P (Sepp1) contains most of the selenium in blood plasma, and it is utilized by the kidney, brain, and testis as a selenium source for…”
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Maternal‐fetal transfer of selenium in the mouse by Burk, Raymond F., Olson, Gary E., Hill, Kristina E., Winfrey, Virginia P., Motley, Amy K., Kurokawa, Suguru

“…Selenoprotein P (Sepp1) is taken up by receptor‐mediated endocytosis for its selenium. The other extracellular selenoprotein, glutathione peroxidase‐3 (Gpx3),…”
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Selenoprotein P is the major selenium transport protein in mouse milk by Hill, Kristina E, Motley, Amy K, Winfrey, Virginia P, Burk, Raymond F

“…Selenium is transferred from the mouse dam to its neonate via milk. Milk contains selenium in selenoprotein form as selenoprotein P (Sepp1) and glutathione…”
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Apolipoprotein E Receptor-2 (ApoER2) Mediates Selenium Uptake from Selenoprotein P by the Mouse Testis by Olson, Gary E., Winfrey, Virginia P., NagDas, Subir K., Hill, Kristina E., Burk, Raymond F.

“…Selenium is a micronutrient that is essential for the production of normal spermatozoa. The selenium-rich plasma protein selenoprotein P (Sepp1) is required…”
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Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells by Olson, Gary E, Whitin, John C, Hill, Kristina E, Winfrey, Virginia P, Motley, Amy K, Austin, Lori M, Deal, Jacqualyn, Cohen, Harvey J, Burk, Raymond F

“…Glutathione peroxidase-3 (Gpx3), also known as plasma or extracellular glutathione peroxidase, is a selenoprotein secreted primarily by kidney proximal…”
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Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed by Burk, Raymond F, Hill, Kristina E, Olson, Gary E, Weeber, Edwin J, Motley, Amy K, Winfrey, Virginia P, Austin, Lori M

“…Selenoprotein P (Sepp1) is a plasma and extracellular protein that is rich in selenium. Deletion of Sepp1 results in sharp decreases of selenium levels in the…”
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Selenoprotein P Is Required for Mouse Sperm Development by OLSON, Gary E, WINFREY, Virginia P, NAGDAS, Subir K, HILL, Kristina E, BURK, Raymond F

“…Selenoprotein P (SEPP1), an extracellular glycoprotein of unknown function, is a unique member of the selenoprotein family that, depending on species, contains…”
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Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1 by Kurokawa, Suguru, Eriksson, Sofi, Rose, Kristie L, Wu, Sen, Motley, Amy K, Hill, Salisha, Winfrey, Virginia P, McDonald, W Hayes, Capecchi, Mario R, Atkins, John F, Arnér, Elias S J, Hill, Kristina E, Burk, Raymond F

“…Mouse selenoprotein P (Sepp1) consists of an N-terminal domain (residues 1-239) that contains one selenocysteine (U) as residue 40 in a proposed redox-active…”
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Ultrastructural Features of the Adult Hermaphrodite Gonad of Caenorhabditis elegans: Relations between the Germ Line and Soma by Hall, David H., Winfrey, Virginia P., Blaeuer, Gareth, Hoffman, Loren H., Furuta, Tokiko, Rose, Kimberly L., Hobert, Oliver, Greenstein, David

“…Genetic and embryological experiments have established the Caenorhabditis elegans adult hermaphrodite gonad as a paradigm for studying the control of germline…”
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role for the inositol kinase Ipk1 in ciliary beating and length maintenance by Sarmah, Bhaskarjyoti, Winfrey, Virginia P, Olson, Gary E, Appel, Bruce, Wente, Susan R

“…Cilia project from cells as membranous extensions, with microtubule structural cores assembling from basal bodies by intraflagellar transport (IFT). Here, we…”
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Processing, localization and binding activity of zonadhesin suggest a function in sperm adhesion to the zona pellucida during exocytosis of the acrosome by Bi, Ming, Hickox, John R, Winfrey, Virginia P, Olson, Gary E, Hardy, Daniel M

“…Zonadhesin is a sperm protein that binds in a species-specific manner to the extracellular matrix ZP (zona pellucida) of the mammalian oocyte. The pig…”
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Sequential development of flagellar defects in spermatids and epididymal spermatozoa of selenium-deficient rats by Olson, Gary E, Winfrey, Virginia P, Hill, Kristina E, Burk, Raymond F

“…In this study cauda epididymal spermatozoa of rats maintained on a selenium-deficient diet for 5 and 7 months exhibited an array of flagellar defects…”
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Selenoprotein P and apolipoprotein E receptor‐2 interact at the blood‐brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration by Burk, Raymond F., Hill, Kristina E., Motley, Amy K., Winfrey, Virginia P., Kurokawa, Suguru, Mitchell, Stuart L., Zhang, Wanqi

“…Selenoprotein P (Sepp1) and its receptor, apolipoprotein E receptor 2 (apoER2), account for brain retaining selenium better than other tissues. The primary…”
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Tyrosine Phosphorylation Generates Multiple Isoforms of the Mitochondrial Capsule Protein, Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx), During Hamster Sperm Capacitation by NAGDAS, Subir K, WINFREY, Virginia P, OLSON, Gary E

“…Sperm capacitation is a maturation process, occurring in the female reproductive tract, that produces fertilization-competent spermatozoa. Protein tyrosine…”
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Isolation and Molecular Characterization of AKAP110, a Novel, Sperm-Specific Protein Kinase A-Anchoring Protein by Vijayaraghavan, Srinivasan, Liberty, Greg A, Mohan, Jag, Winfrey, Virginia P, Olson, Gary E, Carr, Daniel W

“…Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the…”
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Zonadhesin Assembly into the Hamster Sperm Acrosomal Matrix Occurs by Distinct Targeting Strategies During Spermiogenesis and Maturation in the Epididymis by OLSON, Gary E, WINFREY, Virginia P, MING BI, HARDY, Daniel M, NAGDAS, Subir K

“…Zonadhesin is the only sperm protein known to bind in a species-specific manner to the zona pellucida. The zonadhesin precursor is a mosaic protein with a…”
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Region-specific Expression and Secretion of the Fibrinogen-related Protein, fgl2, by Epithelial Cells of the Hamster Epididymis and Its Role in Disposal of Defective Spermatozoa by Olson, Gary E., Winfrey, Virginia P., NagDas, Subir K., Melner, Michael H.

“…The cauda epididymidis functions in the storage and protection of mature, fertile spermatozoa. We previously identified a region-specific secretory…”
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Identification of Ras and Its Downstream Signaling Elements and Their Potential Role in Hamster Sperm Motility by NAGDAS, Subir K, WINFREY, Virginia P, OLSON, Gary E

“…Ras, a member of the small G-protein family, regulates multiple signaling pathways in somatic cells. The objectives of the present study included the…”
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