Search Results - "Winer, Hila"

Mechanism of co-operation of mutant IL-7R α and mutant NRAS in acute lymphoblastic leukemia: role of MYC by Winer, Hila, Li, Wenqing, Rodrigues, Gisele, Gower, Tim, Meyer, Thomas Joshua, Hixon, Julie, Durum, Scott K

“…Acute lymphoblastic leukemia (ALL) is an aggressive leukemia which can be derived from either T-cell or B-cell precursors. With current treatments, the…”
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Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins by Winer, Hila, Fraiberg, Milana, Abada, Adi, Dadosh, Tali, Tamim-Yecheskel, Bat-Chen, Elazar, Zvulun

“…Autophagy, a conserved membrane trafficking process, sequesters cytoplasmic components into autophagosomes and targets them for lysosomal degradation. The TNF…”
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Nuphar lutea Extracts Exhibit Anti-Viral Activity against the Measles Virus by Winer, Hila, Ozer, Janet, Shemer, Yonat, Reichenstein, Irit, Eilam-Frenkel, Brit, Benharroch, Daniel, Golan-Goldhirsh, Avi, Gopas, Jacob

“…Different parts of . (yellow water lily) have been used to treat several inflammatory and pathogen-related diseases. It has shown that extracts (NUP) are…”
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A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer by Hsu, Tu Chun, Rodrigues, Gisele O L, Winer, Hila, Hixon, Julie A, Li, Wenqing, Tarasova, Nadya I, Durum, Scott K

“…Four Ras guanine nucleotide-releasing proteins (RasGRP1 through 4) belong to the family of guanine nucleotide exchange factors (GEFs). RasGRPs catalyze the…”
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Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia by Rodrigues, Gisele O L, Li, WenQing, Cramer, Sarah D, Winer, Hila Y, Hsu, Tu Chun, Gower, Timothy, Hixon, Julie A, Durum, Scott K

“…Transduced mouse immature thymocytes can be differentiated into T cells in vitro using the delta-like 4-expressing bone marrow stromal cell line co-culture…”
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Mutations that collaborate with IL-7Ra signaling pathways to drive ALL by Rodrigues, Gisele O.L., Cramer, Sarah D., Winer, Hila Y., Hixon, Julie A., Li, WenQing, Yunes, José Andres, Durum, Scott K.

“…The IL-7 pathway is required for normal T cell development and survival. In recent years the pathway has been shown to be a major driver of acute lymphoblastic…”
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Abstract B57: A combination of IL7Rα and NRAS mutations sheds light on the oncogenesis of T-cell acute lymphoblastic leukemia in a murine model by Winer, Hila, Rodrigues, Gisele, Li, Wenqing, Hixon, Julie, Durum, Scott

“…Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children. While most cases of ALL arise from B-cell precursors, 15% originate from T…”
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Abstract 2462: A combination of IL7Rα and NRAS mutations up-regulates Bcl-2 and cMyc levels leading to formation of T-cell acute lymphoblastic leukemia by Winer, Hila, Rodrigues, Gisele, Li, Wenqing, Hixon, Julie, Durum, Scott K.

“…Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia derived from T-cell precursors. With current treatments, survival rate is high,…”
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Abstract B47: Overexpression of TLX3 or HOXA9 in association mutant IL7R α are sufficient to generate T-ALL in vivo by Rodrigues, Gisele O.L., Hixon, Julie, Winer, Hila, Li, Wenqing, Durum, Scott

“…Abstract Background: Mutations of the IL7Rα chain occur in approximately 10% of pediatric T-cell acute lymphoblastic leukemia cases. While we have shown that…”
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IL-7: Comprehensive review by Winer, Hila, Rodrigues, Gisele O.L, Hixon, Julie A., Aiello, Francesca B., Hsu, Tu Chun, Wachter, Brianna T., Li, Wenqing, Durum, Scott K.

“…•The IL-7 pathway is required for normal T cell development and survival.•Review covers sources of IL-7 and responses to it, abnormalities in disease and…”
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Cooperation between Mutant IL7R and TLX3 Generates Mixed Myeloid/Lymphoid Leukemia from Thymocyte Progenitors by Rodrigues, Gisele Olinto Libanio, Li, Wenqing, Hixon, Julie, Winer, Hila, Hsu, Tu Chun, Gower, Timothy, Cramer, Sarah, Andrews, Caroline, Durum, Scott

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Overexpression of hTLX3 in Association with Mutant IL7Rα Is Sufficient to Generate T-ALL In Vivo and to Transform Thymocytes in Vitro by Rodrigues, Gisele Olinto Libanio, Hixon, Julie, Winer, Hila, Matich, Erica, Andrews, Caroline, Cramer, Sarah, Li, Wenqing, Durum, Scott

“…Mutations of the IL-7Rα chain occur in approximately 10% of pediatric T-cell acute lymphoblastic leukemia cases. While we have shown that mutant IL7Ra is…”
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Novel Role for Autophagy in the Regulation of the Tnfr Family Member, FN14 by Winer-Yanai, Hila

“…Autophagy, a major stress-activated cellular pathway, is responsible for the degradation of cytoplasmic material through fusion with the lysosome. The…”
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