Loss of Bombesin-Induced Feeding Suppression in Gastrin-Releasing Peptide Receptor-Deficient Mice

The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is...

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Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 95; no. 6; pp. 3188 - 3192
Main Authors:	Hampton, Lori L., Ladenheim, Ellen E., Akeson, Mark, Way, James M., Weber, H. Christian, Sutliff, Vince E., Jensen, Robert T., Wine, Lara J., Arnheiter, Heinz, Battey, James F.
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences of the United States of America 17-03-1998 National Acad Sciences National Academy of Sciences The National Academy of Sciences
Subjects:	Alleles Amylases - metabolism Animals Biological Sciences Biology Bombesin - pharmacology Carbachol - pharmacology Dose-Response Relationship, Drug Eating - drug effects Exons Genes Genetic vectors Genomics Lungs Male animals Mice Mice, Mutant Strains Neurology Pancreas - drug effects Peptides Receptors Receptors, Bombesin - agonists Receptors, Bombesin - deficiency Receptors, Bombesin - genetics Rodents Satiation - physiology Satiety Sincalide - pharmacology
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Summary:	The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult. Surprisingly, gene-targeted mice lacking a functional GRP-R gene develop and reproduce normally and show no gross phenotypic abnormalities. However, peripheral administration of bombesin at dosages up to 32 nmol/kg to such mice had no effect on the suppression of glucose intake, whereas normal mice showed a dose-dependent suppression of glucose intake. These data suggest that selective agonists for the GRP-R may be useful in inducing satiety.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Communicated by Julius Axelrod, National Institute of Mental Health, Bethesda, MD To whom reprint requests should be addressed. e-mail: jbattey@pop.nidcd.nih.gov.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.95.6.3188