Search Results - "Windsor, W T"

Probing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptides by Zhang, R, Durkin, J, Windsor, W T, McNemar, C, Ramanathan, L, Le, H V

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tricyclic Farnesyl Protein Transferase Inhibitors:  Crystallographic and Calorimetric Studies of Structure−Activity Relationships by Strickland, Corey L, Weber, Patricia C, Windsor, William T, Wu, Zhen, Le, Hung V, Albanese, Margaret M, Alvarez, Carmen S, Cesarz, David, del Rosario, Joycelyn, Deskus, Jeffrey, Mallams, Alan K, Njoroge, F. George, Piwinski, John J, Remiszewski, Stacy, Rossman, Randall R, Taveras, Arthur G, Vibulbhan, Bancha, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

“…Crystallographic and thermodynamic studies of farnesyl protein transferase (FPT) complexed with novel tricyclic inhibitors provide insights into the observed…”
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Protein Farnesyltransferase Inhibitors Exhibit Potent Antimalarial Activity by Nallan, Laxman, Bauer, Kevin D, Bendale, Pravin, Rivas, Kasey, Yokoyama, Kohei, Hornéy, Carolyn P, Pendyala, Prakash Rao, Floyd, David, Lombardo, Louis J, Williams, David K, Hamilton, Andrew, Sebti, Said, Windsor, William T, Weber, Patricia C, Buckner, Frederick S, Chakrabarti, Debopam, Gelb, Michael H, Van Voorhis, Wesley C

“…New therapeutics to combat malaria are desperately needed. Here we show that the enzyme protein farnesyltransferase (PFT) from the malaria parasite Plasmodium…”
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Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor by Walter, Mark R, Windsor, William T, Nagabhushan, Tattanahalli L, Lundell, Daniel J, Lunn, Charles A, Zauodny, Paul J, Narula, Satwant K

“…The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2…”
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Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10 by Windsor, William T, Syto, Rosalinda, Tsarbopoulos, Anthony, Zhang, Rumin, Durkin, James, Baldwin, Samuel, Paliwal, Smita, Mui, Philip W, Pramanik, Birenda

“…Interleukin 10 (IL-10), which was first discovered by its ability to inhibit the synthesis of various cytokines, most notably gamma interferon, from Th1 helper…”
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Crystal Structure of Farnesyl Protein Transferase Complexed with a CaaX Peptide and Farnesyl Diphosphate Analogue by Strickland, Corey L, Windsor, William T, Syto, Rosalinda, Wang, Lynn, Bond, Richard, Wu, Zhen, Schwartz, Jeffrey, Le, Hung V, Beese, Lorena S, Weber, Patricia C

“…The crystallographic structure of acetyl-Cys-Val-Ile-selenoMet-COOH and α-hydroxyfarnesylphosphonic acid (αHFP) complexed with rat farnesyl protein transferase…”
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A homology model of human interferon alpha-2 by Murgolo, N J, Windsor, W T, Hruza, A, Reichert, P, Tsarbopoulos, A, Baldwin, S, Huang, E, Pramanik, B, Ealick, S, Trotta, P P

“…An atomic coordinate five alpha-helix three-dimensional model is presented for human interferon alpha-2 (HuIFN alpha 2). The HuIFN alpha 2 structure was…”
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Characterization of Ha-Ras, N-Ras, Ki-Ras4A, and Ki-Ras4B as in Vitro Substrates for Farnesyl Protein Transferase and Geranylgeranyl Protein Transferase Type I by Zhang, F L, Kirschmeier, P, Carr, D, James, L, Bond, R W, Wang, L, Patton, R, Windsor, W T, Syto, R, Zhang, R, Bishop, W R

“…Ras proteins are small GTP-binding proteins which are critical for cell signaling and proliferation. Four Ras isoforms exist: Ha-Ras, N-Ras, Ki-Ras4A, and…”
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A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease by Zhang, Rumin, Beyer, Brian M., Durkin, James, Ingram, Richard, Njoroge, F.George, Windsor, William T., Malcolm, Bruce A.

“…The hepatitis C virus (HCV) encodes a chymotrypsin-like serine protease responsible for the processing of HCV nonstructural proteins and which is a promising…”
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Analysis of the conformation and stability of Escherichia coli derived-recombinant human interleukin 4 by circular dichroism by Windsor, William T, Syto, Rosalinda, Le, Hung V, Trotta, Paul P

“…The conformation and stability of Escherichia coli derived recombinant human interleukin 4 (rhuIL-4) have been examined by circular dichroism (CD). Protein…”
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Xenopus transcription factor IIIA binds to the flanking regions of the 5 S RNA gene intragenic control region in a unique and highly ordered state by Windsor, W T, Lee, T C, Daly, T J, Wu, C W

“…The interaction of Xenopus transcription factor IIIA (TFIIIA) with the intragenic control region (ICR) of the 5 S RNA gene was studied by footprinting…”
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Structural and Biological Stability of the Human Interleukin 10 Homodimer by Syto, Rosalinda, Murgolo, Nicholas J, Braswell, Emory H, Mui, Philip, Huang, Eric, Windsor, William T

“…Human interleukin 10 (huIL-10) is a cytokine that regulates the synthesis of type 1 helper T cell derived cytokines such as γ-interferon, interleukin 2, and…”
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Farnesyl Protein Transferase:  Identification of K164α and Y300β as Catalytic Residues by Mutagenesis and Kinetic Studies by Wu, Zhen, Demma, Mark, Strickland, Corey L, Radisky, Evette S, Poulter, C. Dale, Le, Hung V, Windsor, William T

“…Farnesyl protein transferase (FPT) is an α/β heterodimeric zinc enzyme that catalyzes posttranslational farnesylation of many key cellular regulatory proteins,…”
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Kinetics of oxygen binding and subunit assembly for the hemoglobin alpha subunit by Windsor, W T, Philo, J S, Potschka, M, Schuster, T M

“…A thorough kinetic characterization of the O2-binding and self-association reactions of alpha-subunits of human hemoglobin A has been performed. All of the…”
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Purification of Xenopus transcription factor IIIA and 5 S RNA from 7 S ribonucleoprotein particle by ammonium sulfate precipitation by Shang, Z G, Windsor, W T, Liao, Y D, Wu, C W

“…A simple and efficient method for purifying Xenopus transcription factor IIIA from the 7 S particle has been developed by taking advantage of the differential…”
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Thermodynamic and Structural Analysis of Phosphotyrosine Polypeptide Binding to Grb2-SH2 by McNemar, Charles, Snow, Mark E, Windsor, William T, Prongay, Andrew, Mui, Philip, Zhang, Rumin, Durkin, James, Le, Hung V, Weber, Patricia C

“…A thermodynamic analysis using isothermal titration calorimetry (ITC) has been performed to examine the binding interaction between the SH2 (Src homology 2)…”
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High-level expression, purification, kinetic characterization and crystallization of protein farnesyltransferase β-subunit C-terminal mutants by Wu, Zhen, Demma, Mark, Strickland, Corey L., Syto, Rosalinda, Le, Hung V., Windsor, William T., Weber, Patricia C.

“…Protein farnesyltransferase (FPT) is a 97 000 Da heterodimeric enzyme that catalyzes post-translational farnesylation of many cellular regulatory proteins…”
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Purification and crystallization of a complex between human interferon γ receptor (extracellular domain) and human interferon γ by Windsor, William T., Walter, Leigh J., Syto, Rosalinda, Fossetta, James, Cook, William J., Nagabhushan, Tattanahalli L., Walter, Mark R.

“…X‐ray diffraction quality crystals have been obtained from a complex between interferon γ and the extracellular domain of its high‐affinity cell surface…”
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Selective proteolytic cleavage of recombinant human interleukin 4. Evidence for a critical role of the C-terminus by Le, Hung V, Seelig, Gail F, Syto, Rosalinda, Ramanathan, Lata, Windsor, William T, Borkowski, Doreen, Trotta, Paul P

“…Human interleukin 4 is a 129 amino acid lymphokine secreted by activated T cells that exerts pleiotropic biological effects on B and T lymphocytes and other…”
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Crystallization and preliminary X-ray investigation of recombinant human interleukin 10 by Cook, W J, Windsor, W T, Murgolo, N J, Tindall, S H, Nagabhushan, T L, Walter, M R

“…Crystals of recombinant human interleukin 10 have been grown from solutions of ammonium sulfate. The crystals are tetragonal, space group P4(1)2(1)2 or…”
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