Search Results - "Windhorst, Sabine"

Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing by Volksdorf, Thomas, Heilmann, Janina, Eming, Sabine A, Schawjinski, Kathrin, Zorn-Kruppa, Michaela, Ueck, Christopher, Vidal-y-Sy, Sabine, Windhorst, Sabine, Jücker, Manfred, Moll, Ingrid, Brandner, Johanna M

“…Tight junction (TJ) proteins are known to be involved in proliferation and differentiation. These processes are essential for normal skin wound healing. Here,…”
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DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics by Miao, Shumin, Schäfer, Paula, Nojszewski, Jessica, Meyer, Felix, Windhorst, Sabine

“…Chromosomal instability (CIN) is a hallmark of cancer, resulting from misalignment and missegregation of chromosomes during meta- and anaphase, due to…”
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Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis by Arnold, Julia, Schattschneider, Juliana, Blechner, Christine, Krisp, Christoph, Schlüter, Hartmut, Schweizer, Michaela, Nalaskowski, Marcus, Oliveira-Ferrer, Leticia, Windhorst, Sabine

“…The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the…”
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Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma by Ewald, Florian, Grabinski, Nicole, Grottke, Astrid, Windhorst, Sabine, Nörz, Dominik, Carstensen, Lisa, Staufer, Katharina, Hofmann, Bianca T., Diehl, Frank, David, Kerstin, Schumacher, Udo, Nashan, Björn, Jücker, Manfred

“…Cholangiocarcinoma (CCA) is a rare, but devastating disease arising from the epithelium of intrahepatic and extrahepatic bile ducts. There are neither…”
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Radial somatic F‐actin organization affects growth cone dynamics during early neuronal development by Meka, Durga Praveen, Scharrenberg, Robin, Zhao, Bing, Kobler, Oliver, König, Theresa, Schaefer, Irina, Schwanke, Birgit, Klykov, Sergei, Richter, Melanie, Eggert, Dennis, Windhorst, Sabine, Dotti, Carlos G, Kreutz, Michael R, Mikhaylova, Marina, Calderon de Anda, Froylan

“…The centrosome is thought to be the major neuronal microtubule‐organizing center (MTOC) in early neuronal development, producing microtubules with a radial…”
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Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics by Muhs, Stefanie, Paraschiakos, Themistoklis, Schäfer, Paula, Joosse, Simon A, Windhorst, Sabine

“…Centrosomal Protein 55 (CEP55) exhibits various oncogenic activities; it regulates the PI3K-Akt-pathway, midbody abscission, and chromosomal instability (CIN)…”
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Transcriptome-based identification of key actin-binding proteins associated with high metastatic potential in breast cancer by Müller, Christian, Oliveira-Ferrer, Leticia, Müller, Volkmar, Schmalfeldt, Barbara, Windhorst, Sabine

“…Actin-binding proteins (ABPs) are essential for the regulation of morphological plasticity required for tumor cells to metastasize. The aim of this study was…”
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Control of aromatase in hippocampal neurons by Fester, Lars, Brandt, Nicola, Windhorst, Sabine, Pröls, Felicitas, Bläute, Corinna, Rune, Gabriele M.

“…•Estradiol is synthesized in hippocampal neurons.•Aromatase in hippocampal neurons becomes phoshorylated upon treatment of the neurons with…”
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Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity by Chen, Lihua, DeWispelaere, Allison, Dastvan, Frank, Osborne, William R A, Blechner, Christine, Windhorst, Sabine, Daum, Guenter

“…Smooth muscle alpha-actin (SMA) is a marker for the contractile, non-proliferative phenotype of adult smooth muscle cells (SMCs). Upon arterial injury,…”
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Expression of DIAPH1 is up‐regulated in colorectal cancer and its down‐regulation strongly reduces the metastatic capacity of colon carcinoma cells by Lin, Yuan‐Na, Izbicki, Jakob R., König, Alexandra, Habermann, Jens K., Blechner, Christine, Lange, Tobias, Schumacher, Udo, Windhorst, Sabine

“…In most cases, metastatic colorectal cancer is not curable, thus new approaches are necessary to identify novel targets for colorectal cancer therapy…”
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Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density by Middelkamp, Maximilian, Ruck, Lisa, Krisp, Christoph, Sumisławski, Piotr, Mohammadi, Behnam, Dottermusch, Matthias, Meister, Valerie, Küster, Lukas, Schlüter, Hartmut, Windhorst, Sabine, Neumann, Julia E

“…LIN28A overexpression has been identified in malignant brain tumors called embryonal tumors with multilayered rosettes (ETMR) but its specific role during…”
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Key Role of Hyaluronan Metabolism for the Development of Brain Metastases in Triple-Negative Breast Cancer by Hamester, Fabienne, Stürken, Christine, Legler, Karen, Eylmann, Kathrin, Möller, Katrin, Roßberg, Maila, Gorzelanny, Christian, Bauer, Alexander T, Windhorst, Sabine, Schmalfeldt, Barbara, Laakmann, Elena, Müller, Volkmar, Witzel, Isabell, Oliveira-Ferrer, Leticia

“…Breast cancer (BC) is the second-most common cause of brain metastases (BM) and BCBM patients have a reduced quality of life and a poor prognosis. Hyaluronan…”
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Antiproliferative Plant and Synthetic Polyphenolics Are Specific Inhibitors of Vertebrate Inositol-1,4,5-trisphosphate 3-Kinases and Inositol Polyphosphate Multikinase by Mayr, Georg W., Windhorst, Sabine, Hillemeier, Kirsten

“…Inositol-1,4,5-trisphosphate 3-kinases (IP3K) A, B, and C as well as inositol polyphosphate multikinase (IPMK) catalyze the first step in the formation of the…”
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Inositol 1,4,5-Trisphosphate 3-Kinase-A Is a New Cell Motility-promoting Protein That Increases the Metastatic Potential of Tumor Cells by Two Functional Activities by Windhorst, Sabine, Fliegert, Ralf, Blechner, Christine, Möllmann, Katharina, Hosseini, Zara, Günther, Thomas, Eiben, Maike, Chang, Lydia, Lin, Hong-Ying, Fanick, Werner, Schumacher, Udo, Brandt, Burkhard, Mayr, Georg W.

“…Cellular migration is an essential prerequisite for metastatic dissemination of cancer cells. This study demonstrates that the neuron/testis-specific…”
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Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism by Windhorst, Sabine, Blechner, Christine, Lin, Hong-Ying, Elling, Christian, Nalaskowski, Marcus, Kirchberger, Tanja, Guse, Andreas H, Mayr, Georg W

“…In the present study, effects of increased IP3K-A [Ins(1,4,5)P(3) 3-kinase-A] expression were analysed. H1299 cells overexpressing IP3K-A formed branching…”
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Cryo-EM structures of actin binding proteins as tool for drug discovery by Dahlstroem, Christian, Paraschiakos, Themistoklis, Sun, Han, Windhorst, Sabine

“…[Display omitted] Cellular actin dynamic is controlled by a plethora of actin binding proteins (ABPs), including actin nucleating, bundling, cross-linking,…”
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Oncogenic activity and cellular functionality of melanoma associated antigen A3 by Schäfer, Paula, Paraschiakos, Themistoklis, Windhorst, Sabine

“…[Display omitted] Cancer testis antigen Melanoma associated antigen A3 (MAGE-A3) has been subject of research for many years. Being expressed in various tumor…”
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DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells by Flat, Wilhelm, Borowski, Sarah, Paraschiakos, Themistoklis, Blechner, Christine, Windhorst, Sabine

“…[Display omitted] The chemotherapeutic agent paclitaxel (PTX) selectively binds to and stabilizes microtubule (MTs). Also, the activated formin Diaphanous…”
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Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is frequently over-expressed and functions as an oncogene in several tumor types by Windhorst, Sabine, Song, Kai, Gazdar, Adi F.

“…[Display omitted] At present targeted tumor therapy is based on inhibition of proteins or protein mutants that are up-regulated in tumor but not in…”
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New options of cancer treatment employing InsP 6 by Brehm, Maria A, Windhorst, Sabine

“…Many mechanistic studies have been performed to analyze the cellular functions of the highly phosphorylated molecule inositol hexakisphosphate (InsP ) in…”
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