Search Results - "Windhorst, Albert D"

Towards PET imaging of the dynamic phenotypes of microglia by Beaino, Wissam, Janssen, Bieneke, Vugts, Danielle J., Vries, Helga E., Windhorst, Albert D.

“…There is increasing evidence showing the heterogeneity of microglia activation in neuroinflammatory and neurodegenerative diseases. It has been hypothesized…”
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Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs by Van der Veldt, Astrid A.M., Lubberink, Mark, Bahce, Idris, Walraven, Maudy, de Boer, Michiel P., Greuter, Henri N.J.M., Hendrikse, N. Harry, Eriksson, Jonas, Windhorst, Albert D., Postmus, Pieter E., Verheul, Henk M., Serné, Erik H., Lammertsma, Adriaan A., Smit, Egbert F.

“…Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that anti-angiogenic drugs,…”
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PET Imaging of Microglial Activation-Beyond Targeting TSPO by Janssen, Bieneke, Vugts, Danielle J, Windhorst, Albert D, Mach, Robert H

“…Neuroinflammation, which involves microglial activation, is thought to play a key role in the development and progression of neurodegenerative diseases and…”
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Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R) -[11 C]PK11195 Positron Emission Tomography Study by van Berckel, Bart N, Bossong, Matthijs G, Boellaard, Ronald, Kloet, Reina, Schuitemaker, Alie, Caspers, Esther, Luurtsema, Gert, Windhorst, Albert D, Cahn, Wiepke, Lammertsma, Adriaan A, Kahn, René S

“…Background Schizophrenia is a brain disease involving progressive loss of gray matter of unknown cause. Most likely, this loss reflects neuronal damage, which…”
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Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor by Xia, Ruixue, Shi, Shuang, Xu, Zhenmei, Vischer, Henry F., Windhorst, Albert D., Qian, Yu, Duan, Yaning, Liang, Jiale, Chen, Kai, Zhang, Anqi, Guo, Changyou, Leurs, Rob, He, Yuanzheng

“…The histamine H 4 receptor (H 4 R) plays key role in immune cell function and is a highly valued target for treating allergic and inflammatory diseases…”
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Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis by Beaino, Wissam, Janssen, Bieneke, Kooij, Gijs, van der Pol, Susanne M A, van Het Hof, B, van Horssen, Jack, Windhorst, Albert D, de Vries, Helga E

“…Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. The activation status of microglia…”
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Blood-brain barrier P-glycoprotein function in Alzheimer's disease by van Assema, Daniëlle M. E., Lubberink, Mark, Bauer, Martin, van der Flier, Wiesje M., Schuit, Robert C., Windhorst, Albert D., Comans, Emile F. I., Hoetjes, Nikie J., Tolboom, Nelleke, Langer, Oliver, Müller, Markus, Scheltens, Philip, Lammertsma, Adriaan A., van Berckel, Bart N. M.

“…A major pathological hallmark of Alzheimer's disease is accumulation of amyloid-β in senile plaques in the brain. Evidence is accumulating that decreased…”
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[18F]mFBG PET/CT imaging outperforms MRI and [68 Ga]Ga-DOTA-TOC PET/CT in identifying recurrence pheochromocytoma by Suurd, Diederik P. D., Poot, Alex J., van Leeuwaarde, Rachel S., Windhorst, Albert D., Vriens, Menno R., de Keizer, Bart

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[18F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study by Samim, Atia, Blom, Thomas, Poot, Alex J., Windhorst, Albert D., Fiocco, Marta, Tolboom, Nelleke, Braat, Arthur J. A. T., Viol, Sebastiaan L. Meyer, van Rooij, Rob, van Noesel, Max M., Lam, Marnix G. E. H., Tytgat, Godelieve A. M., de Keizer, Bart

“…  Purpose Meta -[ 18 F]fluorobenzylguanidine ([ 18 F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging…”
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The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study by Hagens, Marloes H. J., Golla, Sandeep S. V., Janssen, Bieneke, Vugts, Danielle J., Beaino, Wissam, Windhorst, Albert D., O’Brien-Brown, James, Kassiou, Michael, Schuit, Robert C., Schwarte, Lothar A., de Vries, Helga E., Killestein, Joep, Barkhof, Frederik, van Berckel, Bart N. M., Lammertsma, Adriaan A.

“…Purpose The novel PET tracer [ 11 C]SMW139 binds with high affinity to the P2X 7 receptor, which is expressed on pro-inflammatory microglia. The purposes of…”
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First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis by Verweij, Nicki J. F., Yaqub, Maqsood, Bruijnen, Stefan T. G., Pieplenbosch, S., ter Wee, Marieke M., Jansen, Gerrit, Chen, Qingshou, Low, Philip S., Windhorst, Albert D., Lammertsma, Adriaan A., Hoekstra, Otto S., Voskuyl, Alexandre E., van der Laken, Conny J.

“…Non-invasive imaging of arthritis activity in rheumatoid arthritis (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic…”
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Navigating the landscape of PD-1/PD-L1 imaging tracers: from challenges to opportunities by Badenhorst, Melinda, Windhorst, Albert D, Beaino, Wissam

“…Immunotherapy targeted to immune checkpoint inhibitors, such as the program cell death receptor (PD-1) and its ligand (PD-L1), has revolutionized cancer…”
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Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients by Golla, Sandeep SV, Boellaard, Ronald, Oikonen, Vesa, Hoffmann, Anja, van Berckel, Bart NM, Windhorst, Albert D, Virta, Jere, Haaparanta-Solin, Merja, Luoto, Pauliina, Savisto, Nina, Solin, Olof, Valencia, Ray, Thiele, Andrea, Eriksson, Jonas, Schuit, Robert C, Lammertsma, Adriaan A, Rinne, Juha O

“…Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([18F] DPA-714) binds to the 18-kDa…”
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Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography by Janssen, Bieneke, Vugts, Danielle J., Funke, Uta, Molenaar, Ger T., Kruijer, Perry S., van Berckel, Bart N.M., Lammertsma, Adriaan A., Windhorst, Albert D.

“…Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer's disease, multiple sclerosis and stroke…”
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Δ9-Tetrahydrocannabinol Induces Dopamine Release in the Human Striatum by Bossong, Matthijs G, van Berckel, Bart NM, Boellaard, Ronald, Zuurman, Lineke, Schuit, Robert C, Windhorst, Albert D, van Gerven, Joop M A, Ramsey, Nick F, Lammertsma, Adriaan A, Kahn, René S

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Microglial activation in Alzheimer's disease: an ( R )-[11 C]PK11195 positron emission tomography study by Schuitemaker, Alie, Kropholler, Marc A, Boellaard, Ronald, van der Flier, Wiesje M, Kloet, Reina W, van der Doef, Thalia F, Knol, Dirk L, Windhorst, Albert D, Luurtsema, Gert, Barkhof, Frederik, Jonker, Cees, Lammertsma, Adriaan A, Scheltens, Philip, van Berckel, Bart N.M

“…Abstract Inflammatory mechanisms, like microglial activation, could be involved in the pathogenesis of Alzheimer's disease (AD). ( R )-[11 C]PK11195…”
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Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study by Bankstahl, Jens P, Bankstahl, Marion, Römermann, Kerstin, Wanek, Thomas, Stanek, Johann, Windhorst, Albert D, Fedrowitz, Maren, Erker, Thomas, Müller, Markus, Löscher, Wolfgang, Langer, Oliver, Kuntner, Claudia

“…Elacridar (ELC) and tariquidar (TQD) are generally thought to be nontransported inhibitors of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP),…”
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Expanding Theranostic Radiopharmaceuticals for Tumor Diagnosis and Therapy by Barca, Cristina, Griessinger, Christoph M, Faust, Andreas, Depke, Dominic, Essler, Markus, Windhorst, Albert D, Devoogdt, Nick, Brindle, Kevin M, Schäfers, Michael, Zinnhardt, Bastian, Jacobs, Andreas H

“…Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and molecular imaging (MI), including positron emission tomography (PET),…”
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Evaluation of [18F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood–brain barrier in rats: Kinetics, metabolism, and selectivity by Savolainen, Heli, Windhorst, Albert D, Elsinga, Philip H, Cantore, Mariangela, Colabufo, Nicola A, Willemsen, Antoon TM, Luurtsema, Gert

“…P-glycoprotein is a protective efflux transporter at the blood–brain barrier showing altered function in many neurological disorders. The purpose of this study…”
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Development of [11C]erlotinib Positron Emission Tomography for In Vivo Evaluation of EGF Receptor Mutational Status by BAHCE, Idris, SMIT, Egbert F, LAMMERTSMA, Adriaan A, HARRY HENDRIKSE, N, LUBBERINK, Mark, VAN DER VELDT, Astrid A. M, YAQUB, Maqsood, WINDHORST, Albert D, SCHUIT, Robert C, THUNNISSEN, Erik, HEIDEMAN, Daniëlle A. M, POSTMUS, Pieter E

“…To evaluate whether, in patients with non-small cell lung carcinoma (NSCLC), tumor uptake of [(11)C]erlotinib can be quantified and imaged using positron…”
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