Search Results - "Windheim, Mark"

Interleukin-1 (IL-1) Induces the Lys63-Linked Polyubiquitination of IL-1 Receptor-Associated Kinase 1 To Facilitate NEMO Binding and the Activation of IκBα Kinase by Windheim, Mark, Stafford, Margaret, Peggie, Mark, Cohen, Philip

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chaperoned Ubiquitylation—Crystal Structures of the CHIP U Box E3 Ubiquitin Ligase and a CHIP-Ubc13-Uev1a Complex by Zhang, Minghao, Windheim, Mark, Roe, S. Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos, Pearl, Laurence H.

“…CHIP is a dimeric U box E3 ubiquitin ligase that binds Hsp90 and/or Hsp70 via its TPR-domain, facilitating ubiquitylation of chaperone bound client proteins…”
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Expression of viral CD45 ligand E3/49K on porcine cells reduces human anti-pig immune responses by Pokoyski, Claudia, Baars, Wiebke, Windheim, Mark, Reubold, Thomas F., Zischke, Jasmin, Brinkmann, Antje, Kay-Fedorov, Penelope C., Schwinzer, Reinhard

“…Transgenic expression of protective molecules in porcine cells and tissues is a promising approach to prevent xenograft rejection. Viruses have developed…”
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Interleukin-1-induced activation of the small GTPase Rac1 depends on receptor internalization and regulates gene expression by Windheim, Mark, Hansen, Benjamin

“…Interleukin 1 (IL-1) triggers the internalization of its cognate receptor from the plasma membrane. We recently demonstrated that this internalization is of…”
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Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide by Windheim, Mark, Lang, Christine, Peggie, Mark, Plater, Lorna A, Cohen, Philip

“…MDP (muramyl dipeptide), a component of peptidoglycan, interacts with NOD2 (nucleotide-binding oligomerization domain 2) stimulating the NOD2-RIP2…”
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ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism by Nanda, Sambit K, Nagamori, Tsunehisa, Windheim, Mark, Amu, Sylvia, Aviello, Gabriella, Patterson-Kane, Janet, Arthur, J Simon C, Ley, Steven C, Fallon, Padraic, Cohen, Philip

“…The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2 (Tpl2)…”
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5-Iodotubercidin sensitizes cells to RIPK1-dependent necroptosis by interfering with NFκB signaling by Chauhan, Chanchal, Kraemer, Andreas, Knapp, Stefan, Windheim, Mark, Kotlyarov, Alexey, Menon, Manoj B., Gaestel, Matthias

“…Receptor-interacting protein kinases (RIPK)-1 and -3 play crucial roles in cell fate decisions and are regulated by multiple checkpoint controls. Previous…”
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unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions by Windheim, Mark, Southcombe, Jennifer H, Kremmer, Elisabeth, Chaplin, Lucy, Urlaub, Doris, Falk, Christine S, Claus, Maren, Mihm, Janine, Braithwaite, Myles, Dennehy, Kevin, Renz, Harald, Sester, Martina, Watzl, Carsten, Burgert, Hans-Gerhard

“…The E3 transcription unit of human adenoviruses (Ads) encodes immunomodulatory proteins. Interestingly, the size and composition of the E3 region differs…”
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Interleukin-1-induced gene expression requires the membrane-raft-dependent internalization of the interleukin-1 receptor by Windheim, Mark

“…Interleukin-1 (IL-1) binding to its receptor triggers signaling events at the plasma membrane that are essential but not sufficient for the induction of the…”
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Catch me if you can – wie Adenoviren das humane Immunsystem austricksen by Aichane, Khadija, Windheim, Mark

“…Abstract Human adenoviruses have evolved mechanisms of immune evasion to counteract antiviral measures. The E3/49K protein of species D adenoviruses and its…”
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Characterization of E3/49K, a Novel, Highly Glycosylated E3 Protein of the Epidemic Keratoconjunctivitis-Causing Adenovirus Type 19a by Windheim, Mark, Burgert, Hans-Gerhard

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Enforced Dimerization of CD45 by the Adenovirus E3/49K Protein Inhibits T Cell Receptor Signaling by Windheim, Mark, Reubold, Thomas F, Aichane, Khadija, Gaestel, Matthias, Burgert, Hans-Gerhard

“…Human adenoviruses (HAdVs) are widespread pathogens that generally cause mild infections in immunocompetent individuals but severe or even fatal diseases in…”
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Catch me if you can – wie Adenoviren das humane Immunsystem austricksen by Aichane, Khadija, Windheim, Mark

“…Human adenoviruses have evolved mechanisms of immune evasion to counteract antiviral measures. The E3/49K protein of species D adenoviruses and its secreted…”
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Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology by Windheim, Mark, Peggie, Mark, Cohen, Philip

“…RING (really interesting new gene) and U-box E3 ligases bridge E2 ubiquitin-conjugating enzymes and substrates to enable the transfer of ubiquitin to a lysine…”
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Regulation of NF-κB-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor by Hansen, Benjamin, Dittrich-Breiholz, Oliver, Kracht, Michael, Windheim, Mark

“…Interleukin-1 (IL-1) induces the internalization of its cognate receptor from the plasma membrane. However, it has remained elusive as to how this mechanism…”
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Sorting Motifs in the Cytoplasmic Tail of the Immunomodulatory E3/49K Protein of Species D Adenoviruses Modulate Cell Surface Expression and Ectodomain Shedding by Windheim, Mark, Höning, Stefan, Leppard, Keith N., Butler, Larissa, Seed, Christina, Ponnambalam, Sreenivasan, Burgert, Hans-Gerhard

“…The E3 transcription unit of human species C adenoviruses (Ads) encodes immunomodulatory proteins that mediate direct protection of infected cells. Recently,…”
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Regulation of NF-[kappa]B-dependent gene expression by ligand-induced endocytosis of the interleukin-1 receptor by Hansen, Benjamin, Dittrich-Breiholz, Oliver, Kracht, Michael, Windheim, Mark

“…Interleukin-1 (IL-1) induces the internalization of its cognate receptor from the plasma membrane. However, it has remained elusive as to how this mechanism…”
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A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions by Windheim, Mark, Southcombe, Jennifer H., Kremmer, Elisabeth, Chaplin, Lucy, Urlaub, Doris, Falk, Christine S., Claus, Maren, Mihm, Janine, Braithwaite, Myles, Dennehy, Kevin, Renz, Harald, Sester, Martina, Watzl, Carsten, Burgert, Hans-Gerhard

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The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1 by Ordureau, Alban, Smith, Hilary, Windheim, Mark, Peggie, Mark, Carrick, Emma, Morrice, Nick, Cohen, Philip

“…The protein kinases IRAK [IL-1 (interleukin 1) receptor-associated kinase] 1 and 4 play key roles in a signalling pathway by which bacterial infection or IL-1…”
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Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase by Windheim, Mark, Stafford, Margaret, Peggie, Mark, Cohen, Philip

“…Interleukin 1 (IL-1) has been reported to stimulate the polyubiquitination and disappearance of IL-1 receptor-associated kinase 1 (IRAK1) within minutes. It…”
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