Search Results - "Winder, Matthew L"

MCL-1 is a clinically targetable vulnerability in breast cancer by Winder, Matthew L, Campbell, Kirsteen J

“…Pro-survival members of the BCL-2 family, including MCL-1, are emerging as important proteins during the development and therapeutic response of solid tumors…”
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The aryl hydrocarbon receptor contributes to tissue adaptation of intestinal eosinophils in mice by Diny, Nicola Laura, Schonfeldova, Barbora, Shapiro, Michael, Winder, Matthew L, Varsani-Brown, Sunita, Stockinger, Brigitta

“…Eosinophils are potent sources of inflammatory and toxic mediators, yet they reside in large numbers in the healthy intestine without causing tissue damage. We…”
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Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function by Campbell, Kirsteen J., Mason, Susan M., Winder, Matthew L., Willemsen, Rosalie B. E., Cloix, Catherine, Lawson, Hannah, Rooney, Nicholas, Dhayade, Sandeep, Sims, Andrew H., Blyth, Karen, Tait, Stephen W. G.

“…High levels of the anti-apoptotic BCL-2 family member MCL-1 are frequently found in breast cancer and, appropriately, BH3-mimetic drugs that specifically…”
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PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes by Elvira, Bernat, Vandenbempt, Valerie, Bauzá-Martinez, Julia, Crutzen, Raphaël, Negueruela, Javier, Ibrahim, Hazem, Winder, Matthew L, Brahma, Manoja K, Vekeriotaite, Beata, Martens, Pieter-Jan, Singh, Sumeet Pal, Rossello, Fernando, Lybaert, Pascale, Otonkoski, Timo, Gysemans, Conny, Wu, Wei, Gurzov, Esteban N

“…Type 1 diabetes (T1D) results from autoimmune destruction of β-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play…”
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