Search Results - "Wind, Natasha S."

Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro by Chinje, Edwin C, Cowen, Rachel L, Feng, Jian, Sharma, Sanjeev P, Wind, Natasha S, Harris, Adrian L, Stratford, Ian J

“…Tirapazamine (TPZ) is the lead member of a class of bioreductive drugs currently in phase II and III clinical trials. TPZ requires metabolic activation to give…”
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The synthesis of 2-oxyalkyl-cyclohex-2-enones, related to the bioactive natural products COTC and antheminone A, which possess anti-tumour properties by Arthurs, Claire L., Morris, Gareth A., Piacenti, Michela, Pritchard, Robin G., Stratford, Ian J., Tatic, Tanja, Whitehead, Roger C., Williams, Katharine F., Wind, Natasha S.

“…The syntheses of five novel 2-oxyalkyl-cyclohex-2-enones, structurally related to the natural products COTC and antheminone A, are described. The target…”
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Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: Reversing tumor radioresistance and effecting cure by COWEN, Rachel L, WILLIAMS, Kaye J, CHINJE, Edwin C, JAFFAR, Mohammed, SHEPPARD, Freda C. D, TELFER, Brian A, WIND, Natasha S, STRATFORD, Ian J

“…Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this resistant…”
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(−)-Quinic acid: a versatile precursor for the synthesis of analogues of 2-crotonyloxymethyl-(4 R,5 R,6 R)-4,5,6-trihydroxycyclohex-2-enone (COTC) which possess anti-tumour properties by Arthurs, Claire L., Lingley, Katharine F., Piacenti, Michela, Stratford, Ian J., Tatic, Tanja, Whitehead, Roger C., Wind, Natasha S.

“…Syntheses of three novel analogues of the Streptomyces metabolite COTC are described, using the versatile chiral pool starting material, (−)-quinic acid. The…”
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Analogues of 2-crotonyloxymethyl-(4 R,5 R,6 R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties by Arthurs, Claire L., Wind, Natasha S., Whitehead, Roger C., Stratford, Ian J.

“…The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds…”
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Arene cis-dihydrodiols: Useful precursors for the preparation of analogues of the anti-tumour agent, 2-crotonyloxymethyl-(4 R,5 R,6 R)-4,5,6-trihydroxycyclohex-2-enone (COTC) by Arthurs, Claire L., Raftery, James, Whitby, Helen L., Whitehead, Roger C., Wind, Natasha S., Stratford, Ian J.

“…The synthesis of 6- epi-COTC, a diastereoisomer of Streptomyces metabolite 2-crotonyloxymethyl-(4 R,5 R,6 R)-4,5,6-trihydroxycyclohex-2-enone (COTC), is…”
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3-Substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro by Jaffar, Mohammed, Phillips, Roger M, Williams, Kaye J, Mrema, Ibrahim, Cole, Christian, Wind, Natasha S, Ward, Timothy H, Stratford, Ian J, Patterson, Adam V

“…Indolequinone agents are a unique class of bioreductive cytotoxins that can function as dual substrates for both one- and two-electron reductases. This endows…”
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Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy by Cowen, Rachel L., Williams, Kaye J., Chinje, Edwin C., Jaffar, Mohammed, Sheppard, Freda C. D., Telfer, Brian A., Wind, Natasha S., Stratford, Ian J.

“…Abstract Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this…”
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