Search Results - "Wincovitch, S."

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk by Rees, M. G., Wincovitch, S., Schultz, J., Waterstradt, R., Beer, N. L., Baltrusch, S., Collins, F. S., Gloyn, A. L.

“…Aims/hypothesis Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene…”
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Nuclear bud formation: a novel manifestation of Zidovudine genotoxicity by Dutra, A, Pak, E, Wincovitch, S, John, K, Poirier, M C, Olivero, O A

“…Normal diploid somatic mammalian cell division generates 2 daughter cells as a result of a strict and well-controlled mitotic process. However, some defects…”
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A quantitative determination of multi-protein interactions by the analysis of confocal images using a pixel-by-pixel assessment algorithm by Goucher, D. R., Wincovitch, S. M., Garfield, S. H., Carbone, K. M., Malik, T. H.

“…Motivation: Recent advances in confocal microscopy have allowed scientists to assess the expression, and to some extent, the interaction/colocalization of…”
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Kinetics of penetration influence the apparent potency of vanilloids on TRPV1 by Lazar, Jozsef, Braun, Derek C, Tóth, Attila, Wang, Yun, Pearce, Larry V, Pavlyukovets, Vladimir A, Blumberg, Peter M, Garfield, Susan H, Wincovitch, Stephen, Choi, Hyun-Kyung, Lee, Jeewoo

“…Evidence that the ligand binding site of TRPV1 lies on the inner face of the plasma membrane and that much of the TRPV1 itself is localized to internal…”
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Grading melanocytic dysplasia in paraffin wax embedded tissue by the nucleic acid index by Berman, D M, Wincovitch, S, Garfield, S, Romeo, M J

“…Background: Although nucleic acid derangements are the hallmark of melanocytic dysplasia, the gold standard for its diagnosis remains the microscopic…”
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Melanosomal Sequestration of Cytotoxic Drugs Contributes to the Intractability of Malignant Melanomas by Chen, Kevin G., Valencia, Julio C., Lai, Barry, Zhang, Guofeng, Paterson, Jill K., Rouzaud, François, Berens, Werner, Wincovitch, Stephen M., Garfield, Susan H., Leapman, Richard D., Hearing, Vincent J., Gottesman, Michael M.

“…Multidrug resistance mechanisms underlying the intractability of malignant melanomas remain largely unknown. In this study, we demonstrate that the development…”
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CARP-2 Is an Endosome-Associated Ubiquitin Ligase for RIP and Regulates TNF-Induced NF-κB Activation by Liao, Wentao, Xiao, Qi, Tchikov, Vladimir, Fujita, Ken-ichi, Yang, Wensheng, Wincovitch, Stephen, Garfield, Susan, Conze, Dietrich, El-Deiry, Wafik S., Schütze, Stefan, Srinivasula, Srinivasa M.

“…The proinflammatory cytokine tumor necrosis factor-α (TNF-α) elicits cellular responses by signaling through a receptor complex that includes the essential…”
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ING2 Regulates the Onset of Replicative Senescence by Induction of p300-Dependent p53 Acetylation by Pedeux, Remy, Sengupta, Sagar, Shen, Jiang Cheng, Demidov, Oleg N., Saito, Shin'ichi, Onogi, Hitoshi, Kumamoto, Kensuke, Wincovitch, Stephen, Garfield, Susan H., McMenamin, Mary, Nagashima, Makoto, Grossman, Steven R., Appella, Ettore, Harris, Curtis C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Different Roles For K+ Channels in Cisplatin-resistant Cell Lines Argue Against a Critical Role for These Channels in Cisplatin Resistance by LIANG, Xing-Jie, TAYLOR, Barbara, CARDARELLI, Carol, YIN, Jun-Jie, ANNEREAU, Jean-Philippe, GARFIELD, Susan, WINCOVITCH, Stephen, SZAKACS, Gergely, GOTTESMAN, Michael M, ASZALOS, Adorjan

“…Cisplatin resistance has been associated with altered K + fluxes. Here, we focused our investigations on the detection of K + channels in a series of…”
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Trafficking and localization of platinum complexes in cisplatin-resistant cell lines monitored by fluorescence-labeled platinum by Liang, Xing-Jie, Shen, Ding-Wu, Chen, Kevin G., Wincovitch, Stephen M., Garfield, Susan H., Gottesman, Michael M.

“…Cisplatin is a chemotherapeutic agent commonly used in the treatment of a wide variety of malignant tumors. Resistance to cisplatin represents a major obstacle…”
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