Search Results - "Winandy, Susan"

A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells by Steinbuck, Martin Peter, Winandy, Susan

“…The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems, and its deregulation has been…”
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Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes by Chari, Sheila, Winandy, Susan

“…Both Ikaros and Notch are essential for normal T cell development. Collaborative mutations causing a reduction in Ikaros activity and an increase in Notch…”
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Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros by Winandy, Susan, Bertolino, Eric, Singh, Harinder, L Reddy, Karen, Schjerven, Hilde, A Demarco, Ignacio, Chen, Zhengshan, Smale, Stephen T, Reynaud, Damien

“…The transcription factor Ikaros has many functions essential for hematopoiesis. Singh and colleagues show that Ikaros is required for RAG recombinase…”
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Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease by Toubai, Tomomi, Sun, Yaping, Tawara, Isao, Friedman, Ann, Liu, Chen, Evers, Rebecca, Nieves, Evelyn, Malter, Chelsea, Chockley, Peter, Maillard, Ivan, Winandy, Susan, Reddy, Pavan

“…Host hematopoietically derived APCs play a vital role in the initiation of GVH responses. However, the APC autonomous molecular mechanisms that are critical…”
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Ikaros DNA-Binding Proteins Direct Formation of Chromatin Remodeling Complexes in Lymphocytes by Kim, John, Sif, Saïd, Jones, Beverly, Jackson, Audrey, Koipally, Joseph, Heller, Elizabeth, Winandy, Susan, Viel, Alain, Sawyer, Alan, Ikeda, Toru, Kingston, Robert, Georgopoulos, Katia

“…The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here,…”
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A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma by Winandy, Susan, Wu, Paul, Georgopoulos, Katia

“…The Ikaros gene is essential for lymphoid lineage specification. As previously reported, mice homozygous for a mutation in the Ikaros DNA-binding domain fail…”
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THE ROLE OF THE IKAROS GENE IN LYMPHOCYTE DEVELOPMENT AND HOMEOSTASIS by Georgopoulos, Katia, Winandy, Susan, Avitahl, Nicole

“…The Ikaros gene, which encodes a family of hemopoietic-specific zinc finger proteins, is described as a central regulator of lymphocyte differentiation. During…”
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Ikaros Induces Quiescence and T-Cell Differentiation in a Leukemia Cell Line by Kathrein, Katie L., Lorenz, Rachelle, Innes, Angela Minniti, Griffiths, Erin, Winandy, Susan

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line by Kathrein, Katie L., Chari, Sheila, Winandy, Susan

“…Ikaros and Notch1, two regulators of gene transcription, are critically important at many stages of T cell development. Deregulation of Ikaros and Notch…”
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Ikaros to the rescue of TCR‐α chain gene rearrangement by Winandy, Susan

“…Ikaros is a transcriptional regulator critical for B‐ and T‐cell development. Recently, it has been shown to play a central role in facilitating rearrangement…”
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Novel TCR-Mediated Mechanisms of Notch Activation and Signaling by Steinbuck, Martin Peter, Arakcheeva, Ksenia, Winandy, Susan

“…The Notch receptor is an evolutionarily highly conserved transmembrane protein that is essential to a wide spectrum of cellular systems. Notch signaling is…”
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Ikaros to the rescue of TCR-[alpha] chain gene rearrangement by Winandy, Susan

“…Ikaros is a transcriptional regulator critical for B- and T-cell development. Recently, it has been shown to play a central role in facilitating rearrangement…”
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Novel T-cell receptor mediated mechanisms of Notch activation and signaling by Steinbuck, Martin Peter, Arakcheeva, Ksenia, Winandy, Susan

“…The Notch receptor is an evolutionarily highly conserved transmembrane protein essential to a wide spectrum of cellular systems. Notch signaling is especially…”
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Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells by Lyon de Ana, Carolina, Arakcheeva, Ksenia, Agnihotri, Parul, Derosia, Nicole, Winandy, Susan

“…CD4 Th cells are organizers of the immune response, directing other immune cells to initiate and maintain effective humoral and cellular immunity. CD4 T cells…”
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Defective Flt3L driven DC development in the absence of Ikaros (111.35) by Brugmann, William, Winandy, Susan

“…Abstract Ikaros null (Ik-) mice have impaired dendritic cell (DC) development. This defect is recapitulated when Ik- bone marrow (BM) is cultured with Flt3L, a…”
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Ikaros Is a Regulator of Il10 Expression in CD4+ T Cells by Umetsu, Sarah E, Winandy, Susan

“…IL-10 is a regulatory cytokine critical for controlling inflammatory responses. Here we show that Ikaros, a zinc finger DNA-binding protein, plays an important…”
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Ikaros null mice demonstrate defects in dendritic cell development. (36.17) by Brugmann, William, Winandy, Susan

“…Abstract Ikaros is a transcription factor that is expressed almost exclusively in cells of the hematopoietic lineage. Ikaros null mice lack several…”
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Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells by Agnihotri, Parul, Robertson, Nicholas M., Umetsu, Sarah E., Arakcheeva, Ksenia, Winandy, Susan

“…Summary Ikaros is a transcription factor that regulates lymphocyte development from the level of the haematopoietic stem cell. Lack of Ikaros reduces the…”
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Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line: IMPLICATIONS FOR CD4 REGULATION by Kathrein, Katie L, Chari, Sheila, Winandy, Susan

“…Ikaros and Notch1, two regulators of gene transcription, are critically important at many stages of T cell development. Deregulation of Ikaros and Notch…”
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Notch target gene deregulation and leukemogenesis occur independently of RBPJ in Ikaros null thymocytes. (138.23) by Chari, Sheila, Winandy, Susan

“…Abstract Both Ikaros and Notch are transcriptional regulators that are essential for normal T cell development. Cooperative mutations causing a reduction in…”
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