Search Results - "Winand, M"

Molecular and clinical heterogeneity of adult diffuse low-grade IDH wild-type gliomas: assessment of TERT promoter mutation and chromosome 7 and 10 copy number status allows superior prognostic stratification by Wijnenga, Maarten M. J., Dubbink, Hendrikus J., French, Pim J., Synhaeve, Nathalie E., Dinjens, Winand N. M., Atmodimedjo, Peggy N., Kros, Johan M., Dirven, Clemens M. F., Vincent, Arnaud J. P. E., van den Bent, Martin J.

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SDHA Immunohistochemistry Detects Germline SDHA Gene Mutations in Apparently Sporadic Paragangliomas and Pheochromocytomas by Korpershoek, Esther, Favier, Judith, Gaal, José, Burnichon, Nelly, van Gessel, Bram, Oudijk, Lindsey, Badoual, Cécile, Gadessaud, Noémie, Venisse, Annabelle, Bayley, Jean-Pierre, van Dooren, Marieke F, de Herder, Wouter W, Tissier, Frédérique, Plouin, Pierre-François, van Nederveen, Francien H, Dinjens, Winand N. M, Gimenez-Roqueplo, Anne-Paule, de Krijger, Ronald R

“…Context: Pheochromocytoma-paraganglioma syndrome is caused by mutations in SDHB, SDHC, and SDHD, encoding subunits of succinate dehydrogenase (SDH), and in…”
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The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis by Wijnenga, Maarten M J, French, Pim J, Dubbink, Hendrikus J, Dinjens, Winand N M, Atmodimedjo, Peggy N, Kros, Johan M, Smits, Marion, Gahrmann, Renske, Rutten, Geert-Jan, Verheul, Jeroen B, Fleischeuer, Ruth, Dirven, Clemens M F, Vincent, Arnaud J P E, van den Bent, Martin J

“…Extensive resections in low-grade glioma (LGG) are associated with improved overall survival (OS). However, World Health Organization (WHO) classification of…”
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Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951 by VAN DEN BENT, Martin J, BRANDES, Alba A, SIPOS, László, ENTING, Roelien H, FRENCH, Pim J, DINJENS, Winand N. M, VECHT, Charles J, ALLGEIER, Anouk, LACOMBE, Denis, GORLIA, Thierry, HOANG-XUAN, Khê, TAPHOORN, Martin J. B, KROS, Johan M, KOUWENHOVEN, Mathilde C. M, DELATTRE, Jean-Yves, BERNSEN, Hans J. J. A, FRENAY, Marc, TIJSSEN, Cees C, GRISOLD, Wolfgang

“…Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a randomized phase III study on the addition…”
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IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study by Li, Yunlei, Buijs-Gladdines, Jessica G C A M, Canté-Barrett, Kirsten, Stubbs, Andrew P, Vroegindeweij, Eric M, Smits, Willem K, van Marion, Ronald, Dinjens, Winand N M, Horstmann, Martin, Kuiper, Roland P, Buijsman, Rogier C, Zaman, Guido J R, van der Spek, Peter J, Pieters, Rob, Meijerink, Jules P P

“…Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related mortality in children. T cell ALL…”
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IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group by VAN DEN BENT, Martin J, DUBBINK, Hendrikus J, VAN MARION, Ronald, KROS, Johan M, DINJENS, Winand N. M, GORLIA, Thierry, SANSON, Marc, MARIE, Yannick, BRANDES, Alba A, TAPHOORN, Martin J. B, WESSELING, Pieter, FRENAY, Marc, TIJSSEN, Cees C, LACOMBE, Denis, IDBAIH, Ahmed

“…Recent studies have shown the prognostic significance of IDH1 mutations in glioma. It is yet unclear if IDH1 mutations are predictive for outcome to…”
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Health Promoting Sports Federations: theoretical foundations and guidelines by Van Hoye, A, Geidne, S, Vuillemin, A, Whiting, S, Winand, M

“…Abstract The potential for organised sports to promote health has been underexploited so far, according to researchers and policy-makers. Sports clubs have…”
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Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations by Janeway, Katherine A, Kim, Su Young, Lodish, Maya, Nosé, Vânia, Rustin, Pierre, Gaal, José, Dahia, Patricia L.M, Liegl, Bernadette, Ball, Evan R, Raygada, Margarita, Lai, Angela H, Kelly, Lorna, Hornick, Jason L, O'Sullivan, Maureen, de Krijger, Ronald R, Dinjens, Winand N.M, Demetri, George D, Antonescu, Cristina R, Fletcher, Jonathan A, Helman, Lee, Stratakis, Constantine A

“…Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by…”
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Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial by Dubbink, Hendrikus J, Atmodimedjo, Peggy N, Kros, Johan M, French, Pim J, Sanson, Marc, Idbaih, Ahmed, Wesseling, Pieter, Enting, Roelien, Spliet, Wim, Tijssen, Cees, Dinjens, Winand N M, Gorlia, Thierry, van den Bent, Martin J

“…Histopathological diagnosis of diffuse gliomas is subject to interobserver variation and correlates modestly with major prognostic and predictive molecular…”
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Somatic aberrations of mismatch repair genes as a cause of microsatellite-unstable cancers by Geurts-Giele, Willemina RR, Leenen, Celine HM, Dubbink, Hendrikus J, Meijssen, Isabelle C, Post, Edward, Sleddens, Hein FBM, Kuipers, Ernst J, Goverde, Anne, van den Ouweland, Ans MW, van Lier, Margot GF, Steyerberg, Ewout W, van Leerdam, Monique E, Wagner, Anja, Dinjens, Winand NM

“…Lynch syndrome (LS) is caused by germline mutations in mismatch repair (MMR) genes, resulting in microsatellite‐unstable tumours. Approximately 35% of…”
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Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples by Mankor, Joanne M., Paats, Marthe S., Groenendijk, Floris H., Roepman, Paul, Dinjens, Winand N. M., Dubbink, Hendrikus J., Sleijfer, Stefan, Cuppen, Edwin, Lolkema, Martijn P. J. K.

“…Tumour mutational burden (TMB) has emerged as a promising biomarker to predict immune checkpoint inhibitors (ICIs) response in advanced solid cancers. However,…”
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Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines by Hollestelle, Antoinette, Nagel, Jord H. A, Smid, Marcel, Lam, Suzanne, Elstrodt, Fons, Wasielewski, Marijke, Ng, Ser Sue, French, Pim J, Peeters, Justine K, Rozendaal, Marieke J, Riaz, Muhammad, Koopman, Daphne G, ten Hagen, Timo L. M, de Leeuw, Bertie H. C. G. M, Zwarthoff, Ellen C, Teunisse, Amina, van der Spek, Peter J, Klijn, Jan G. M, Dinjens, Winand N. M, Ethier, Stephen P, Clevers, Hans, Jochemsen, Aart G, den Bakker, Michael A, Foekens, John A, Martens, John W. M, Schutte, Mieke

“…Breast cancer has for long been recognized as a highly diverse tumor group, but the underlying genetic basis has been elusive. Here, we report an extensive…”
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Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum by Niemeijer, Nicolasine D, Papathomas, Thomas G, Korpershoek, Esther, de Krijger, Ronald R, Oudijk, Lindsey, Morreau, Hans, Bayley, Jean-Pierre, Hes, Frederik J, Jansen, Jeroen C, Dinjens, Winand N. M, Corssmit, Eleonora P. M

“…Context: Mutations in genes encoding the subunits of succinate dehydrogenase (SDH) can lead to pheochromocytoma/paraganglioma formation. However, SDH mutations…”
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SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors by Gaal, José, Stratakis, Constantine A, Carney, J Aidan, Ball, Evan R, Korpershoek, Esther, Lodish, Maya B, Levy, Isaac, Xekouki, Paraskevi, van Nederveen, Francien H, den Bakker, Michael A, O'Sullivan, Maureen, Dinjens, Winand NM, de Krijger, Ronald R

“…Mutations in the tumor suppressor genes SDHB , SDHC , and SDHD (or collectively SDHx ) cause the inherited paraganglioma syndromes, characterized by…”
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Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells by Pan, Qiuwei, Fouraschen, Suomi M G, de Ruiter, Petra E, Dinjens, Winand N M, Kwekkeboom, Jaap, Tilanus, Hugo W, van der Laan, Luc J W

“…Human mesenchymal stem/stromal cells (MSCs) have been explored in a number of clinical trials as a possible method of treating various diseases. However, the…”
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Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing by Pruis, Melinda A., Groenendijk, Floris H., Badloe, K. Sangeeta, van Puffelen, Andrea, Robbrecht, Debbie, Dinjens, Winand N. M., Sleijfer, Stefan, Dingemans, Anne-Marie C., von der Thüsen, Jan H., Roepman, Paul, Lolkema, Martijn P.

“…Background Biomarker-guided therapy in an experimental setting has been suggested to improve patient outcomes. However, trial-specific pre-screening tests are…”
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Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis by Apellaniz-Ruiz, Maria, Sabbaghian, Nelly, Chong, Anne-Laure, de Kock, Leanne, Cetinkaya, Semra, Bayramoğlu, Elvan, Dinjens, Winand N. M., McCluggage, W. Glenn, Wagner, Anja, Yilmaz, Aslihan Arasli, Foulkes, William D.

“…DICER1  syndrome is an inherited condition associated with an increased risk of developing hamartomatous and neoplastic lesions in diverse organs, mainly at…”
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Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines by Boonstra, Jurjen J., van Marion, Ronald, Beer, David G., Lin, Lin, Chaves, Paula, Ribeiro, Catarina, Pereira, A. Dias, Roque, Lúcia, Darnton, S. Jane, Altorki, Nasser K., Schrump, David S., Klimstra, David S., Tang, Laura H., Eshleman, James R., Alvarez, Hector, Shimada, Yutaka, van Dekken, Herman, Tilanus, Hugo W., Dinjens, Winand N. M.

“…For decades, hundreds of different human tumor type–specific cell lines have been used in experimental cancer research as models for their respective tumors…”
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Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC–PGL syndromes: a clinicopathological and molecular analysis by Papathomas, Thomas G, Gaal, Jose, Corssmit, Eleonora P M, Oudijk, Lindsey, Korpershoek, Esther, Heimdal, Ketil, Bayley, Jean-Pierre, Morreau, Hans, van Dooren, Marieke, Papaspyrou, Konstantinos, Schreiner, Thomas, Hansen, Torsten, Andresen, Per Arne, Restuccia, David F, van Kessel, Ingrid, van Leenders, Geert J L H, Kros, Johan M, Looijenga, Leendert H J, Hofland, Leo J, Mann, Wolf, van Nederveen, Francien H, Mete, Ozgur, Asa, Sylvia L, de Krijger, Ronald R, Dinjens, Winand N M

“…ObjectiveAlthough the succinate dehydrogenase (SDH)-related tumor spectrum has been recently expanded, there are only rare reports of…”
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Three-Gene Immunohistochemical Panel Adds to Clinical Staging Algorithms to Predict Prognosis for Patients With Esophageal Adenocarcinoma by ONG, Chin-Ann J, SHAPIRO, Joel, WORSTER, Susannah, SCHULZ, Laura K. E, LUKETICH, James D, WIJNHOVEN, Bas P. L, HARDWICK, Richard H, FITZGERALD, Rebecca C, NASON, Katie S, DAVISON, Jon M, XINXUE LIU, ROSS-INNES, Caryn, O'DONOVAN, Maria, DINJENS, Winand N. M, BIERMANN, Katharina, SHANNON, Nicholas

“…Esophageal adenocarcinoma (EAC) is a highly aggressive disease with poor long-term survival. Despite growing knowledge of its biology, no molecular biomarkers…”
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