Search Results - "Wimmer, Mathieu"

Gadd45b: at the intersection of transcriptional and epigenetic changes associated with cocaine-related behaviors by Wimmer, Mathieu E

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Aging in mice reduces the ability to sustain sleep/wake states by Wimmer, Mathieu E, Rising, Justin, Galante, Raymond J, Wyner, Abraham, Pack, Allan I, Abel, Ted

“…One of the most significant problems facing older individuals is difficulty staying asleep at night and awake during the day. Understanding the mechanisms by…”
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Aging impairs hippocampus-dependent long-term memory for object location in mice by Wimmer, Mathieu E, Hernandez, Pepe J, Blackwell, Jennifer, Abel, Ted

“…Abstract The decline in cognitive function that accompanies normal aging has a negative impact on the quality of life of the elderly and their families…”
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Cyclic AMP response element-binding protein is required in excitatory neurons in the forebrain to sustain wakefulness by Wimmer, Mathieu E, Cui, Rosa, Blackwell, Jennifer M, Abel, Ted

“…Abstract The molecular and intracellular signaling processes that control sleep and wake states remain largely unknown. A consistent observation is that the…”
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Rolipram treatment during consolidation ameliorates long-term object location memory in aged male mice by Wimmer, Mathieu E., Blackwell, Jennifer M., Abel, Ted

“…•Aged mice show long-term object location memory deficits.•The PDE4 inhibitor rolipram enhanced memory consolidation in aged animals.•Rolipram rescued…”
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Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes by Carpenter, Marco D., Hu, Qiwen, Bond, Allison M., Lombroso, Sonia I., Czarnecki, Kyle S., Lim, Carissa J., Song, Hongjun, Wimmer, Mathieu E., Pierce, R. Christopher, Heller, Elizabeth A.

“…Endogenous homeostatic mechanisms can restore normal neuronal function following cocaine-induced neuroadaptations. Such mechanisms may be exploited to develop…”
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A role for lateral hypothalamic orexin neurons in reward seeking by Wimmer, Mathieu, Harris, Glenda C, Aston-Jones, Gary

“…The lateral hypothalamus is a brain region historically implicated in reward and motivation, but the identity of the neurotransmitters involved are unknown…”
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Environmental, genetic and epigenetic contributions to cocaine addiction by Pierce, R Christopher, Fant, Bruno, Swinford-Jackson, Sarah E, Heller, Elizabeth A, Berrettini, Wade H, Wimmer, Mathieu E

“…Decades of research on cocaine has produced volumes of data that have answered many important questions about the nature of this highly addictive drug. Sadly,…”
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Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations by Vassoler, Fair M., Wimmer, Mathieu E.

“…Substance abuse and the ongoing opioid epidemic represents a large societal burden. This review will consider the long-term impact of opioid exposure on future…”
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Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis by Tudor, Jennifer C, Davis, Emily J, Peixoto, Lucia, Wimmer, Mathieu E, van Tilborg, Erik, Park, Alan J, Poplawski, Shane G, Chung, Caroline W, Havekes, Robbert, Huang, Jiayan, Gatti, Evelina, Pierre, Philippe, Abel, Ted

“…Sleep deprivation is a public health epidemic that causes wide-ranging deleterious consequences, including impaired memory and cognition. Protein synthesis in…”
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Early resource scarcity alters motivation for natural rewards in a sex- and reinforcer-dependent manner by Williams, Alexia V., Flowers, James, Coates, Kennedy S., Ingram, Atiba, Hehn, Alexandra T., Dupuis, Molly, Wimmer, Mathieu E., Venniro, Marco, Bangasser, Debra A.

“…Rationale Early life adversity impacts reward-related behaviors, including reward seeking for drugs of abuse. However, the effects of early stress on natural…”
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microRNA expression levels in the nucleus accumbens correlate with morphine‐taking but not morphine‐seeking behaviour in male rats by Gillespie, Aria, Mayberry, Hannah L., Wimmer, Mathieu E., Sillivan, Stephanie E.

“…A powerful motivation to seek opioids remains after drug cessation and intensifies during extended periods of abstinence. Unfortunately, biomarkers associated…”
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How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets by Peixoto, Lucia, Risso, Davide, Poplawski, Shane G, Wimmer, Mathieu E, Speed, Terence P, Wood, Marcelo A, Abel, Ted

“…The sequencing of the full transcriptome (RNA-seq) has become the preferred choice for the measurement of genome-wide gene expression. Despite its widespread…”
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Chromatin-mediated alternative splicing regulates cocaine-reward behavior by Xu, Song-Jun, Lombroso, Sonia I., Fischer, Delaney K., Carpenter, Marco D., Marchione, Dylan M., Hamilton, Peter J., Lim, Carissa J., Neve, Rachel L., Garcia, Benjamin A., Wimmer, Mathieu E., Pierce, R. Christopher, Heller, Elizabeth A.

“…Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the spliceosome machinery is insufficient to fully specify splicing…”
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Glucagon-Like Peptide-1 Receptor Activation in the Ventral Tegmental Area Decreases the Reinforcing Efficacy of Cocaine by Schmidt, Heath D, Mietlicki-Baase, Elizabeth G, Ige, Kelsey Y, Maurer, John J, Reiner, David J, Zimmer, Derek J, Van Nest, Duncan S, Guercio, Leonardo A, Wimmer, Mathieu E, Olivos, Diana R, De Jonghe, Bart C, Hayes, Matthew R

“…Cocaine addiction continues to be a significant public health problem for which there are currently no effective FDA-approved treatments. Thus, there is a…”
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Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking by Guercio, Leonardo A., Wimmer, Mathieu E., Schmidt, Heath D., Swinford-Jackson, Sarah E., Pierce, R. Christopher, Vassoler, Fair M.

“…•DBS of the infralimbic cortex attenuated cocaine seeking.•DBS of the prelimbic cortex and anterior cingulate had no effect on cocaine seeking.•DBS of the…”
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Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes by Sanchez, Evelyn Ordoñes, Bavley, Charlotte C., Deutschmann, Andre U., Carpenter, Rachel, Peterson, Drew R., Karbalaei, Reza, Flowers, James, Rogers, Charleanne M., Langrehr, Miranda G., Ardekani, Cory S., Famularo, Sydney T., Bongiovanni, Angela R., Knouse, Melissa C., Floresco, Stan B., Briand, Lisa A., Wimmer, Mathieu E., Bangasser, Debra A.

“…Experiencing some early life adversity can have an “inoculating” effect that promotes resilience in adulthood. However, the mechanisms underlying stress…”
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Transcriptomics in the nucleus accumbens shell reveal sex- and reinforcer-specific signatures associated with morphine and sucrose craving by Mayberry, Hannah L, Bavley, Charlotte C, Karbalaei, Reza, Peterson, Drew R, Bongiovanni, Angela R, Ellis, Alexandra S, Downey, Sara H, Toussaint, Andre B, Wimmer, Mathieu E

“…Incubation of craving is a well-documented phenomenon referring to the intensification of drug craving over extended abstinence. The neural adaptations that…”
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Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory by Prince, Toni-Moi, Wimmer, Mathieu, Choi, Jennifer, Havekes, Robbert, Aton, Sara, Abel, Ted

“…•Sleep deprivation for 3h impairs memory when onset occurs 1h after training.•Sleep deprivation for 3h impairs LTP when onset occurs 1h after training.•Sleep…”
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Cocaine-Induced Changes in Sperm Cdkn1a Methylation Are Associated with Cocaine Resistance in Male Offspring by Swinford-Jackson, Sarah E, Fant, Bruno, Wimmer, Mathieu E, Chan, Donovan, Knouse, Melissa C, Sarmiento, Mateo, Thomas, Arthur S, Huffman, Phillip J, Mankame, Sharvari, Worobey, Samantha J, Pierce, R Christopher

“…Paternal environmental perturbations can influence the physiology and behavior of offspring. For example, our previous work showed reduced cocaine…”
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