Search Results - "Wim Timens"

The pathology of chronic obstructive pulmonary disease by Hogg, James C, Timens, Wim

“…The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune response to the inhalation of toxic…”
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Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine by Brandsma, Corry‐Anke, Van den Berge, Maarten, Hackett, Tillie‐Louise, Brusselle, Guy, Timens, Wim

“…Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high personal and societal burden. Exposure to toxic particles and gases,…”
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Can ACE2 expression explain SARS‐CoV‐2 infection of the respiratory epithelia in COVID‐19? by Nawijn, Martijn C, Timens, Wim

“…Infection with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) leads to coronavirus disease 2019 (COVID‐19), which poses an unprecedented…”
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Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19) by Bourgonje, Arno R, Abdulle, Amaal E, Timens, Wim, Hillebrands, Jan‐Luuk, Navis, Gerjan J, Gordijn, Sanne J, Bolling, Marieke C, Dijkstra, Gerard, Voors, Adriaan A, Osterhaus, Albert DME, Voort, Peter HJ, Mulder, Douwe J, Goor, Harry

“…Angiotensin‐converting enzyme 2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2),…”
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The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease by Schiller, Herbert B, Montoro, Daniel T, Simon, Lukas M, Rawlins, Emma L, Meyer, Kerstin B, Strunz, Maximilian, Vieira Braga, Felipe A, Timens, Wim, Koppelman, Gerard H, Budinger, G R Scott, Burgess, Janette K, Waghray, Avinash, van den Berge, Maarten, Theis, Fabian J, Regev, Aviv, Kaminski, Naftali, Rajagopal, Jayaraj, Teichmann, Sarah A, Misharin, Alexander V, Nawijn, Martijn C

“…Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing…”
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Lung ageing and COPD: is there a role for ageing in abnormal tissue repair? by Brandsma, Corry-Anke, de Vries, Maaike, Costa, Rita, Woldhuis, Roy R, Königshoff, Melanie, Timens, Wim

“…Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is…”
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High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD by van Nijnatten, Jos, Brandsma, Corry-Anke, Steiling, Katrina, Hiemstra, Pieter S., Timens, Wim, van den Berge, Maarten, Faiz, Alen

“…Smoking is a leading cause of chronic obstructive pulmonary disease (COPD). It is known to have a significant impact on gene expression and (inflammatory) cell…”
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Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 by Hernández Cordero, Ana I., Li, Xuan, Milne, Stephen, Yang, Chen Xi, Bossé, Yohan, Joubert, Philippe, Timens, Wim, van den Berge, Maarten, Nickle, David, Hao, Ke, Sin, Don D.

“…SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) and the current health crisis. Despite intensive research efforts, the genes and pathways…”
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Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank by Valette, Kim, Li, Zhonglin, Bon-Baret, Valentin, Chignon, Arnaud, Bérubé, Jean-Christophe, Eslami, Aida, Lamothe, Jennifer, Gaudreault, Nathalie, Joubert, Philippe, Obeidat, Ma’en, van den Berge, Maarten, Timens, Wim, Sin, Don D., Nickle, David C., Hao, Ke, Labbé, Catherine, Godbout, Krystelle, Côté, Andréanne, Laviolette, Michel, Boulet, Louis-Philippe, Mathieu, Patrick, Thériault, Sébastien, Bossé, Yohan

“…To identify candidate causal genes of asthma, we performed a genome-wide association study (GWAS) in UK Biobank on a broad asthma definition (n = 56,167 asthma…”
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Immune microenvironment composition in non‐small cell lung cancer and its association with survival by Tamminga, Menno, Hiltermann, Thijo Jeroen N, Schuuring, Ed, Timens, Wim, Fehrmann, Rudolf SN, Groen, Harry JM

“…Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its composition affect survival. In this in silico study, the immune…”
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Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma by Osei, Emmanuel T., B. Mostaço-Guidolin, Leila, Hsieh, Aileen, Warner, Stephanie M., AL-Fouadi, May, Wang, Mary, Cole, Darren J., Maksym, Geoffrey N., S. Hallstrand, Teal, Timens, Wim, Brandsma, Corry-Anke, Heijink, Irene H., Hackett, Tillie-Louise

“…In asthma, the airway epithelium has an impaired capacity to differentiate and plays a key role in the development of airway inflammation and remodeling…”
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miR-146a-5p plays an essential role in the aberrant epithelial-fibroblast cross-talk in COPD by Osei, Emmanuel T, Florez-Sampedro, Laura, Tasena, Hataitip, Faiz, Alen, Noordhoek, Jacobien A, Timens, Wim, Postma, Dirkje S, Hackett, Tillie L, Heijink, Irene H, Brandsma, Corry-Anke

“…We previously reported that epithelial-derived interleukin (IL)-1α drives fibroblast-derived inflammation in the lung epithelial-mesenchymal trophic unit…”
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Distinct macrophage phenotypes in allergic and nonallergic lung inflammation by Robbe, Patricia, Draijer, Christina, Borg, Thiago R, Luinge, Marjan, Timens, Wim, Wouters, Inge M, Melgert, Barbro N, Hylkema, Machteld N

“…Chronic exposure to farm environments is a risk factor for nonallergic lung disease. In contrast to allergic asthma, in which type 2 helper T cell (Th2)…”
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Gene expression network analysis provides potential targets against SARS-CoV-2 by Hernández Cordero, Ana I., Li, Xuan, Yang, Chen Xi, Milne, Stephen, Bossé, Yohan, Joubert, Philippe, Timens, Wim, van den Berge, Maarten, Nickle, David, Hao, Ke, Sin, Don D.

“…Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine…”
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The Genetic Epidemiology of Pediatric Pulmonary Arterial Hypertension by Haarman, Meindina G., Kerstjens-Frederikse, Wilhelmina S., Vissia-Kazemier, Theresia R., Breeman, Karel T.N., Timens, Wim, Vos, Yvonne J., Roofthooft, Marc T.R., Hillege, Hans L., Berger, Rolf M.F.

“…To describe the prevalence of pulmonary arterial hypertension (PAH)-associated gene mutations, and other genetic characteristics in a national cohort of…”
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Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension by Smolders, V. F. E. D., Rodríguez, C., Blanco, I., Szulcek, R., Timens, Wim, Piccari, L., Roger, Y., Hu, X., Morén, Constanza, Bonjoch, C., Sebastián, L., Castellà, M., Osorio, J., Peinado, V. I., Bogaard, Harm Jan, Quax, P. H. A., Cascante, M., Barberà, J. A., Tura-Ceide, O.

“…Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are two forms of pulmonary hypertension (PH) characterized by…”
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More alternative activation of macrophages in lungs of asthmatic patients by Melgert, Barbro N., PhD, ten Hacken, Nick H., MD, PhD, Rutgers, Bea, BSc, Timens, Wim, MD, PhD, Postma, Dirkje S., MD, PhD, Hylkema, Machteld N., PhD

“…[...]a significantly higher percentage of macrophages with an alternatively activated phenotype (ie, either CD206 [macrophage mannose receptor] or stabilin-1…”
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Adverse pulmonary vascular remodeling in the Fontan circulation by Ridderbos, Floris-Jan S., BSc, Wolff, Djoeke, MD, Timmer, Albertus, MD, PhD, van Melle, Joost P., MD, PhD, Ebels, Tjark, MD, PhD, Dickinson, Michael G., MD, PhD, Timens, Wim, MD, PhD, Berger, Rolf M.F., MD, PhD

“…Background The Fontan circulation is a palliation for patients with a functionally univentricular heart. It is characterized by gradual attrition over time. An…”
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Atypical goblet cell hyperplasia occurs in CPAM 1, 2, and 3, and is a probable precursor lesion for childhood adenocarcinoma by Fakler, Fabian, Aykutlu, Umut, Brcic, Luka, Eidenhammer, Sylvia, Thueringer, Andrea, Kashofer, Karl, Kulka, Janina, Timens, Wim, Popper, Helmut

“…Congenital pulmonary airway malformation (CPAM) is a developmental disorder. Types 1-2-3 are the more common ones. Atypical goblet cell hyperplasia (AGCH) in…”
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Collagen type XIV is proportionally lower in the lung tissue of patients with IPF by Nizamoglu, Mehmet, Koloko Ngassie, Maunick Lefin, Meuleman, Rhode A., Banchero, Martin, Borghuis, Theo, Timens, Wim, Nawijn, Martijn C., Melgert, Barbro N., Heijink, Irene H., Brandsma, Corry-Anke, Burgess, Janette K.

“…Abnormal deposition of extracellular matrix (ECM) in lung tissue is a characteristic of idiopathic pulmonary fibrosis (IPF). Increased collagen deposition is…”
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