Search Results - "Wiltshire, Timothy D."

Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair by Wiltshire, Timothy D., Lovejoy, Courtney A., Wang, Tong, Xia, Fen, O'Connor, Mark J., Cortez, David

“…DNA damage repair and checkpoint responses prevent genome instability and provide a barrier to the development of cancer. Inherited mutations in DNA damage…”
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Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 by Singh, Namit, Basnet, Harihar, Wiltshire, Timothy D, Mohammad, Duaa H, Thompson, James R, Héroux, Annie, Botuyan, Maria Victoria, Yaffe, Michael B, Couch, Fergus J, Rosenfeld, Michael G, Mer, Georges

“…Tyr142, the C-terminal amino acid of histone variant H2A.X is phosphorylated by WSTF (Williams-Beuren syndrome transcription factor), a component of the WICH…”
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Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease by Murphy, Stephen J, Hart, Steven N, Halling, Geoffrey C, Johnson, Sarah H, Smadbeck, James B, Drucker, Travis, Lima, Joema Felipe, Rohakhtar, Fariborz Rakhshan, Harris, Faye R, Kosari, Farhad, Subramanian, Subbaya, Petersen, Gloria M, Wiltshire, Timothy D, Kipp, Benjamin R, Truty, Mark J, McWilliams, Robert R, Couch, Fergus J, Vasmatzis, George

“…Many somatic mutations have been detected in pancreatic ductal adenocarcinoma (PDAC), leading to the identification of some key drivers of disease progression,…”
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Sensitive detection of integrated and free transcripts in chimeric antigen receptor T-cell manufactured cell products using droplet digital polymerase chain reaction by Wiltshire, Timothy D., Milosevic, Dragana, Jacob, Eapen K., Grebe, Stefan K., Dietz, Allan B.

“…Viral vectors are commonly used to introduce chimeric antigen receptor (CAR) constructs into cell therapy products for the treatment of human disease. They are…”
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Antibodies as drugs—a Keystone Symposia report by Cable, Jennifer, Saphire, Erica Ollmann, Hayday, Adrian C., Wiltshire, Timothy D., Mousa, Jarrod J., Humphreys, David P., Breij, Esther C. W., Bruhns, Pierre, Broketa, Matteo, Furuya, Genta, Hauser, Blake M., Mahévas, Matthieu, Carfi, Andrea, Cantaert, Tineke, Kwong, Peter D., Tripathi, Prabhanshu, Davis, Jonathan H., Brewis, Neil, Keyt, Bruce A., Fennemann, Felix L., Dussupt, Vincent, Sivasubramanian, Arvind, Kim, Philip M., Rawi, Reda, Richardson, Eve, Leventhal, Daniel, Wolters, Rachael M., Geuijen, Cecile A. W., Sleeman, Matthew A., Pengo, Niccolo, Donnellan, Francesca Rose

“…Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research…”
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Management of externally manufactured cell therapy products: the Mayo Clinic approach by Wiltshire, Timothy D., Deeds, Michael C., Radel, Darcie J., Bornschlegl, Alexander M., Schmidt, Clint S., Thebiay, Julia M., Pelleymounter, Linda L., Jacob, Eapen K., Stubbs, James R., Gastineau, Dennis A., Dietz, Allan B.

“…The rise of investigative and commercially available cell therapy products adds a new dynamic to academic medical centers; that is, the management of…”
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Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern by Li, Maggie, Beck, Evan J., Laeyendecker, Oliver, Eby, Yolanda, Tobian, Aaron AR, Caturegli, Patrizio, Wouters, Camille, Chiklis, Gregory R., Block, William, McKie, Robert O., Joyner, Michael J., Wiltshire, Timothy D., Dietz, Allan B., Gniadek, Thomas J., Shapiro, Arell J., Yarava, Anusha, Lane, Karen, Hanley, Daniel F., Bloch, Evan M., Shoham, Shmuel, Cachay, Edward R., Meisenberg, Barry R., Huaman, Moises A., Fukuta, Yuriko, Patel, Bela, Heath, Sonya L., Levine, Adam C., Paxton, James H., Anjan, Shweta, Gerber, Jonathan M., Gebo, Kelly A., Casadevall, Arturo, Pekosz, Andrew, Sullivan, David J.

“…The ongoing evolution of SARS-Co-V2 variants to omicron severely limits available effective monoclonal antibody therapies. Effective drugs are also supply…”
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Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex by Singh, Namit, Wiltshire, Timothy D., Thompson, James R., Mer, Georges, Couch, Fergus J.

“…Microcephalin (MCPH1), the first gene identified as causative for primary recessive autosomal microcephaly, is aberrantly expressed in autism-like disorders…”
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Abstract 2133: MCPH1 interacts with the anaphase-promoting complex subunit Cdc27 by Wiltshire, Timothy D., Singh, Namit, Mer, Georges, Couch, Fergus

“…Abstract Microcephalin (MCPH1), the first gene identified as causative for primary recessive autosomal microcephaly, is aberrantly expressed in autism-like…”
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DNA damage response activated by anti-cancer agent, irofulven by Wiltshire, Timothy D

“…The DNA damage response is a complex network of signals that coordinate to protect cells from accumulating mutations that lead to the development of cancer…”
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DNA damage response activated by anti-cancer agent, irofulven by Wiltshire, Timothy D

“…The DNA damage response is a complex network of signals that coordinate to protect cells from accumulating mutations that lead to the development of cancer…”
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