Search Results - "Wiltgen, Brian J."

Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval by Tanaka, Kazumasa Z., Pevzner, Aleksandr, Hamidi, Anahita B., Nakazawa, Yuki, Graham, Jalina, Wiltgen, Brian J.

“…The hippocampus is assumed to retrieve memory by reinstating patterns of cortical activity that were observed during learning. To test this idea, we monitored…”
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Reactivation of Neural Ensembles during the Retrieval of Recent and Remote Memory by Tayler, Kaycie K., Tanaka, Kazumasa Z., Reijmers, Leon G., Wiltgen, Brian J.

“…Episodic memories are encoded within hippocampal and neocortical circuits. Retrieving these memories is assumed to involve reactivation of neural ensembles…”
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Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses by Clement, James P., Aceti, Massimiliano, Creson, Thomas K., Ozkan, Emin D., Shi, Yulin, Reish, Nicholas J., Almonte, Antoine G., Miller, Brooke H., Wiltgen, Brian J., Miller, Courtney A., Xu, Xiangmin, Rumbaugh, Gavin

“…Mutations that cause intellectual disability (ID) and autism spectrum disorder (ASD) are commonly found in genes that encode for synaptic proteins. However, it…”
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The Hippocampus Plays a Selective Role in the Retrieval of Detailed Contextual Memories by Wiltgen, Brian J., Zhou, Miou, Cai, Ying, Balaji, J., Karlsson, Mikael Guzman, Parivash, Sherveen N., Li, Weidong, Silva, Alcino J.

“…It is widely believed that the hippocampus plays a temporary role in the retrieval of episodic and contextual memories. Initial research indicated that damage…”
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High-Frequency Stimulation of Ventral CA1 Neurons Reduces Amygdala Activity and Inhibits Fear by Graham, Jalina, D'Ambra, Alexa F, Jung, Se Jung, Teratani-Ota, Yusuke, Vishwakarma, Nina, Venkatesh, Rasika, Parigi, Abhijna, Antzoulatos, Evan G, Fioravante, Diasynou, Wiltgen, Brian J

“…The hippocampus can be divided into distinct segments that make unique contributions to learning and memory. The dorsal segment supports cognitive processes…”
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Context Fear Learning in the Absence of the Hippocampus by Wiltgen, Brian J, Sanders, Matthew J, Anagnostaras, Stephan G, Sage, Jennifer R, Fanselow, Michael S

“…Lesions of the rodent hippocampus invariably abolish context fear memories formed in the recent past but do not always prevent new learning. To better…”
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Acute Disruption of the Dorsal Hippocampus Impairs the Encoding and Retrieval of Trace Fear Memories by Wilmot, Jacob H, Puhger, Kyle, Wiltgen, Brian J

“…A major function of the hippocampus is to link discontiguous events in memory. This process can be studied in animals using Pavlovian trace conditioning, a…”
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Light enhances learned fear by Warthen, Daniel M, Wiltgen, Brian J, Provencio, Ignacio

“…The ability to learn, remember, and respond to emotional events is a powerful survival strategy. However, dysregulated behavioral and physiological responses…”
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A role for calcium-permeable AMPA receptors in synaptic plasticity and learning by Wiltgen, Brian J, Royle, Gordon A, Gray, Erin E, Abdipranoto, Andrea, Thangthaeng, Nopporn, Jacobs, Nate, Saab, Faysal, Tonegawa, Susumu, Heinemann, Stephen F, O'Dell, Thomas J, Fanselow, Michael S, Vissel, Bryce

“…A central concept in the field of learning and memory is that NMDARs are essential for synaptic plasticity and memory formation. Surprisingly then, multiple…”
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The hippocampus contributes to retroactive stimulus associations during trace fear conditioning by Puhger, Kyle, Crestani, Ana P., Diniz, Cassiano R.A. F., Wiltgen, Brian J.

“…Binding events that occur at different times are essential for memory formation. In trace fear conditioning, animals associate a tone and footshock despite no…”
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The place of the hippocampus in fear conditioning by Sanders, Matthew J, Wiltgen, Brian J, Fanselow, Michael S

“…Pavlovian fear conditioning is a phenomenon amenable to laboratory analysis of the neurobiology of fear and the investigation of neural mechanisms of learning…”
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The effect of ratio and interval training on Pavlovian-instrumental transfer in mice by Wiltgen, Brian J, Sinclair, Courtney, Lane, Chadrick, Barrows, Frank, Molina, Martín, Chabanon-Hicks, Chloe

“…Conditional stimuli (CS) that are paired with reward can be used to motivate instrumental responses. This process is called Pavlovian-instrumental transfer…”
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A contextual binding theory of episodic memory: systems consolidation reconsidered by Yonelinas, Andrew P., Ranganath, Charan, Ekstrom, Arne D., Wiltgen, Brian J.

“…Episodic memory reflects the ability to recollect the temporal and spatial context of past experiences. Episodic memories depend on the hippocampus but have…”
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Characterization of NMDAR-Independent Learning in the Hippocampus by Tayler, Kaycie Kuss, Lowry, Elizabeth, Tanaka, Kazumasa, Levy, Brynne, Reijmers, Leon, Mayford, Mark, Wiltgen, Brian J

“…It is currently thought that memory formation requires the activation of NMDA receptors (NMDARs) in the hippocampus. However, recent studies indicate that…”
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A high through-put reverse genetic screen identifies two genes involved in remote memory in mice by Matynia, Anna, Anagnostaras, Stephan G, Wiltgen, Brian J, Lacuesta, Maress, Fanselow, Michael S, Silva, Alcino J

“…Previous studies have revealed that the initial stages of memory formation require several genes involved in synaptic, transcriptional and translational…”
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Memory retrieval along the proximodistal axis of CA1 by Nakazawa, Yuki, Pevzner, Aleksandr, Tanaka, Kazumasa Z., Wiltgen, Brian J.

“…ABSTRACT The proximal and distal segments of CA1 are thought to perform distinct computations. Neurons in proximal CA1 are reciprocally connected with the…”
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Memory for Context becomes Less Specific with Time by Wiltgen, Brian J, Silva, Alcino J

“…Context memories initially require the hippocampus, but over time become independent of this structure. This shift reflects a consolidation process whereby…”
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Systems consolidation and the content of memory by Wiltgen, Brian J., Tanaka, Kazumasa Z.

“…•Context memories in rodents do not always undergo systems consolidation.•We describe several factors that influence whether these memories become independent…”
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The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala by Wiltgen, Brian

“…Synaptic plasticity in the amydgala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that…”
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Reply to ‘Active and effective replay: systems consolidation reconsidered again’ by Yonelinas, Andrew P., Ranganath, Charan, Ekstrom, Arne D., Wiltgen, Brian J.

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