Search Results - "Wilson Hawken, Susana"

Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription by Pomplun, Sebastian, Jbara, Muhammad, Schissel, Carly K, Wilson Hawken, Susana, Boija, Ann, Li, Charles, Klein, Isaac, Pentelute, Bradley L

“…Dysregulation of the transcription factor MYC is involved in many human cancers. The dimeric transcription factor complexes of MYC/MAX and MAX/MAX activate or…”
Get full text

203 RNA Polymerase II Meningioma Mutations Activate Forebrain Neurodevelopmental Pathways by Clark, Victoria Elizabeth, Prager, Briana, Wilson-Hawken, Susana, Young, Richard

Get full text

Partitioning of cancer therapeutics in nuclear condensates by Klein, Isaac A, Boija, Ann, Afeyan, Lena K, Hawken, Susana Wilson, Fan, Mengyang, Dall'Agnese, Alessandra, Oksuz, Ozgur, Henninger, Jonathan E, Shrinivas, Krishna, Sabari, Benjamin R, Sagi, Ido, Clark, Victoria E, Platt, Jesse M, Kar, Mrityunjoy, McCall, Patrick M, Zamudio, Alicia V, Manteiga, John C, Coffey, Eliot L, Li, Charles H, Hannett, Nancy M, Guo, Yang Eric, Decker, Tim-Michael, Lee, Tong Ihn, Zhang, Tinghu, Weng, Jing-Ke, Taatjes, Dylan J, Chakraborty, Arup, Sharp, Phillip A, Chang, Young Tae, Hyman, Anthony A, Gray, Nathanael S, Young, Richard A

“…The nucleus contains diverse phase-separated condensates that compartmentalize and concentrate biomolecules with distinct physicochemical properties. Here, we…”
Get full text

Transcription factors interact with RNA to regulate genes by Oksuz, Ozgur, Henninger, Jonathan E., Warneford-Thomson, Robert, Zheng, Ming M., Erb, Hailey, Vancura, Adrienne, Overholt, Kalon J., Hawken, Susana Wilson, Banani, Salman F., Lauman, Richard, Reich, Lauren N., Robertson, Anne L., Hannett, Nancy M., Lee, Tong I., Zon, Leonard I., Bonasio, Roberto, Young, Richard A.

“…Transcription factors (TFs) orchestrate the gene expression programs that define each cell’s identity. The canonical TF accomplishes this with two domains, one…”
Get full text

Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents by Jbara, Muhammad, Pomplun, Sebastian, Schissel, Carly K, Hawken, Susana Wilson, Boija, Ann, Klein, Isaac, Rodriguez, Jacob, Buchwald, Stephen L, Pentelute, Bradley L

“…Transcription factors (TF), such as Myc, are proteins implicated in disease pathogenesis, with dysregulation of Myc expression in 50% of all human cancers…”
Get full text

Abstract GS3-10: Partitioning of cancer therapeutics in nuclear condensates by Klein, Isaac, Boija, Ann, Afeyan, Lena, Hawken, Susana Wilson, Fan, Mengyang, Dall'Agnese, Alessandra, Oksuz, Ozgur, Henninger, Jonathan, Shrinivas, Krishna, Sabari, Benjamin, Sagi, Ido, Clark, Victoria, Platt, Jesse, Kar, Mrityunjoy, McCall, Patrick, Zamudio, Alicia, Mantiega, John, Coffey, Eliot, Li, Charles, Hannett, Nancy, Guo, Yang, Decker, Tim-Michael, Lee, Tong, Zhang, Tinghu, Weng, Jing-Ke, Taatjes, Dylan, Chakraborty, Arup, Sharp, Phillip, Chang, Young Tae, Hyman, Anthony, Gray, Nathanael, Young, Richard

“…The molecules of the cell are compartmentalized into membrane- and non-membrane-bound organelles. Many non-membrane-bound organelles are phase-separated…”
Get full text