Search Results - "Wilson, William K"

NOESY and DFT-GIAO Calculations Reveal Pervasive Errors in C20 Configurations of Taraxastane-3,20-diols: Proposals to Improve NMR Structure Determinations by Shan, Hui, Wilson, William K, Kamaric, Emma

“…The current scientific consensus generally assigns incorrect C20 configurations to taraxastane-3β,20-diols and their oxo derivatives reported in 32 articles…”
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Product Profile of PEN3: The Last Unexamined Oxidosqualene Cyclase in Arabidopsis thaliana by Morlacchi, Pietro, Wilson, William K, Xiong, Quanbo, Bhaduri, Aparna, Sttivend, Diana, Kolesnikova, Mariya D, Matsuda, Seiichi P. T

“…The triterpene product profile is reported for At5g36150 (PEN3), the last unexamined oxidosqualene cyclase in the reference plant Arabidopsis thaliana. PEN3…”
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Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination by Hubler, Zita, Allimuthu, Dharmaraja, Bederman, Ilya, Elitt, Matthew S., Madhavan, Mayur, Allan, Kevin C., Shick, H. Elizabeth, Garrison, Eric, T. Karl, Molly, Factor, Daniel C., Nevin, Zachary S., Sax, Joel L., Thompson, Matthew A., Fedorov, Yuriy, Jin, Jing, Wilson, William K., Giera, Martin, Bracher, Franz, Miller, Robert H., Tesar, Paul J., Adams, Drew J.

“…Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem cell population in the central nervous system (CNS) and the principal…”
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Stereochemistry of Water Addition in Triterpene Synthesis:  The Structure of Arabidiol by Kolesnikova, Mariya D, Obermeyer, Allie C, Wilson, William K, Lynch, David A, Xiong, Quanbo, Matsuda, Seiichi P. T

“…An oxidosqualene cyclase from Arabidopsis thaliana makes arabidiol, a tricyclic triterpene reported with indeterminate side-chain stereochemistry. We…”
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A Putative Precursor of Isomalabaricane Triterpenoids from Lanosterol Synthase Mutants by Lodeiro, Silvia, Wilson, William K, Shan, Hui, Matsuda, Seiichi P. T

“…Known lanosterol synthase mutants produce monocyclic or tetracyclic byproducts from oxidosqualene. We describe Erg7 Tyr510 mutants that cause partial substrate…”
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Enzymatic Cyclization of Dioxidosqualene to Heterocyclic Triterpenes by Shan, Hui, Segura, Michael J. R, Wilson, William K, Lodeiro, Silvia, Matsuda, Seiichi P. T

“…Oxidosqualene cyclases normally produce triterpenes from 2,3-(S)-oxidosqualene (OS) but also can cyclize its minor companion (3S,22S)-2,3:22,23-dioxidosqualene…”
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Cholesterol Import by Aspergillus fumigatus and Its Influence on Antifungal Potency of Sterol Biosynthesis Inhibitors by QUANBO XIONG, HASSAN, Saad A, WILSON, William K, HAN, Xiang Y, MAY, Gregory S, TARRAND, Jeffrey J, MATSUDA, Seiichi P. T

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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An Arabidopsis Oxidosqualene Cyclase Catalyzes Iridal Skeleton Formation by Grob Fragmentation by Xiong, Quanbo, Wilson, William K., Matsuda, Seiichi P. T.

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Cloning and characterization of the Arabidopsis thaliana lupeol synthase gene by R. Herrera, Jennifer B, Bartel, Bonnie, Wilson, William K, Matsuda, Seiichi P.T

“…A 2274 bp Arabidopsis thaliana cDNA was isolated that encodes a protein 57% identical to cycloartenol synthase from the same organism. The expressed…”
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Directed Evolution To Investigate Steric Control of Enzymatic Oxidosqualene Cyclization. An Isoleucine-to-Valine Mutation in Cycloartenol Synthase Allows Lanosterol and Parkeol Biosynthesis by Hart, Elizabeth A, Hua, Ling, Darr, Lisa B, Wilson, William K, Pang, Jihai, Matsuda, Seiichi P. T

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Enzymatic Synthesis of an Indole Diterpene by an Oxidosqualene Cyclase:  Mechanistic, Biosynthetic, and Phylogenetic Implications by Xiong, Quanbo, Zhu, Xiuwen, Wilson, William K, Ganesan, A, Matsuda, Seiichi P. T

“…Petromindole (1) is an unusual indole diterpene that bears a triterpene-like carbon skeleton, suggesting biogenesis from 3-(ω-oxido-geranylgeranyl)indole (4)…”
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An Oxidosqualene Cyclase Makes Numerous Products by Diverse Mechanisms:  A Challenge to Prevailing Concepts of Triterpene Biosynthesis by Lodeiro, Silvia, Xiong, Quanbo, Wilson, William K, Kolesnikova, Mariya D, Onak, Carl S, Matsuda, Seiichi P. T

“…The genome of the model plant Arabidopsis thaliana encodes 13 oxidosqualene cyclases, 9 of which have been characterized by heterologous expression in yeast…”
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Astertarone A Synthase from Chinese Cabbage Does Not Produce the C4-Epimer: Mechanistic Insights by Jin, Jing, Moore, Megan K, Wilson, William K, Matsuda, Seiichi P. T

“…The Brassica rapa oxidosqualene cyclase Bra032185 makes 60% astertarone A (1) and 20 minor triterpenes (0.1–11%). Mechanistic analysis indicates the absence of…”
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A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity by Schmidt, Robert J., Ficorilli, James V., Zhang, Youyan, Bramlett, Kelli S., Beyer, Thomas P., Borchert, Kristen, Dowless, Michele S., Houck, Keith A., Burris, Thomas P., Eacho, Patrick I., Liang, Guosheng, Guo, Li-wei, Wilson, William K., Michael, Laura F., Cao, Guoqing

“…Hypercholesterolemia is a major risk factor for coronary artery disease. Oxysterols are known to inhibit cholesterol biosynthesis and have been explored as…”
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Torsional Failure of Carbon Fiber Composite Plates Versus Stainless Steel Plates for Comminuted Distal Fibula Fractures by Wilson, William K., Morris, Randal P., Ward, Adam J., Carayannopoulos, Nikoletta L., Panchbhavi, Vinod K.

“…Background: Carbon fiber composite implants are gaining popularity in orthopedics, but with few independent studies of their failure characteristics under…”
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Are Isoursenol and γ‑Amyrin Rare Triterpenes in Nature or Simply Overlooked by Usual Analytical Methods? by Shan, Hui, Wilson, William K, Castillo, Dorianne A, Matsuda, Seiichi P. T

“…Among pentacyclic triterpenes commonly found in plants, γ-amyrin and isoursenol are seldom reported and considered rare in nature. It was hypothesized that…”
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Mechanistic insights into triterpene synthesis from quantum mechanical calculations. Detection of systematic errors in B3LYP cyclization energies by Matsuda, Seiichi P T, Wilson, William K, Xiong, Quanbo

“…Most quantum mechanical studies of triterpene synthesis have been done on small models. We calculated mPW1PW91/6-311+G(2d,p)//B3LYP/6-31G* energies for many…”
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The Liebermann–Burchard Reaction: Sulfonation, Desaturation, and Rearrangment of Cholesterol in Acid by Xiong, Quanbo, Wilson, William K., Pang, Jihai

“…In the Liebermann–Burchard (LB) colorimetric assay, treatment of cholesterol with sulfuric acid, acetic anhydride, and acetic acid elicits a blue color. We…”
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Sterols in blood of normal and Smith-Lemli-Opitz subjects by Ruan, B, Wilson, W K, Pang, J, Gerst, N, Pinkerton, F D, Tsai, J, Kelley, R I, Whitby, F G, Milewicz, D M, Garbern, J, Schroepfer, Jr, G J

“…Smith-Lemli-Opitz syndrome (SLOS) is a hereditary disorder in which a defective gene encoding 7-dehydrocholesterol reductase causes the accumulation of…”
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Sterols affecting meiosis: novel chemical syntheses and the biological activity and spectral properties of the synthetic sterols by Ruan, B, Watanabe, S, Eppig, J J, Kwoh, C, Dzidic, N, Pang, J, Wilson, W K, Schroepfer, Jr, G J

“…4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol (I) from human follicular fluid and 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol (II) from bull testes…”
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