Search Results - "Wilson, Marcus D"

A mechanism for the suppression of homologous recombination in G1 cells by Orthwein, Alexandre, Noordermeer, Sylvie M., Wilson, Marcus D., Landry, Sébastien, Enchev, Radoslav I., Sherker, Alana, Munro, Meagan, Pinder, Jordan, Salsman, Jayme, Dellaire, Graham, Xia, Bing, Peter, Matthias, Durocher, Daniel

“…A mechanism for the repression of homologous recombination in G1, the stage of the cell cycle preceding replication, is determined; the critical aspects are…”
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The structural basis of modified nucleosome recognition by 53BP1 by Wilson, Marcus D., Benlekbir, Samir, Fradet-Turcotte, Amélie, Sherker, Alana, Julien, Jean-Philippe, McEwan, Andrea, Noordermeer, Sylvie M., Sicheri, Frank, Rubinstein, John L., Durocher, Daniel

“…A cryo-electron microscopy structure of the DNA damage repair protein 53BP1 bound to a nucleosome illuminates the way 53BP1 recognizes two types of histone…”
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Ubiquitylation and degradation of elongating RNA polymerase II: The last resort by Wilson, Marcus D., Harreman, Michelle, Svejstrup, Jesper Q.

“…During its journey across a gene, RNA polymerase II has to contend with a number of obstacles to its progression, including nucleosomes, DNA-binding proteins,…”
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Proteasome-Mediated Processing of Def1, a Critical Step in the Cellular Response to Transcription Stress by Wilson, Marcus D., Harreman, Michelle, Taschner, Michael, Reid, James, Walker, Jane, Erdjument-Bromage, Hediye, Tempst, Paul, Svejstrup, Jesper Q.

“…DNA damage triggers polyubiquitylation and degradation of the largest subunit of RNA polymerase II (RNAPII), a “mechanism of last resort” employed during…”
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PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1 by Belotserkovskaya, Rimma, Raga Gil, Elisenda, Lawrence, Nicola, Butler, Richard, Clifford, Gillian, Wilson, Marcus D., Jackson, Stephen P.

“…Loss of functional BRCA1 protein leads to defects in DNA double-strand break (DSB) repair by homologous recombination (HR) and renders cells hypersensitive to…”
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BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes by Burdett, Hayden, Foglizzo, Martina, Musgrove, Laura J, Kumar, Dhananjay, Clifford, Gillian, Campbell, Lisa J, Heath, George R, Zeqiraj, Elton, Wilson, Marcus D

“…Abstract Chromatin association of the BRCA1–BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in…”
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Histone divergence in trypanosomes results in unique alterations to nucleosome structure by Deák, Gauri, Wapenaar, Hannah, Sandoval, Gorka, Chen, Ruofan, Taylor, Mark R D, Burdett, Hayden, Watson, James A, Tuijtel, Maarten W, Webb, Shaun, Wilson, Marcus D

“…Abstract Eukaryotes have a multitude of diverse mechanisms for organising and using their genomes, but the histones that make up chromatin are highly…”
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Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer by Wilson, Marcus D., Renault, Ludovic, Maskell, Daniel P., Ghoneim, Mohamed, Pye, Valerie E., Nans, Andrea, Rueda, David S., Cherepanov, Peter, Costa, Alessandro

“…Retroviral integrase can efficiently utilise nucleosomes for insertion of the reverse-transcribed viral DNA. In face of the structural constraints imposed by…”
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MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance by Salguero, Israel, Belotserkovskaya, Rimma, Coates, Julia, Sczaniecka-Clift, Matylda, Demir, Mukerrem, Jhujh, Satpal, Wilson, Marcus D., Jackson, Stephen P.

“…Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then…”
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The PI3K p110δ regulates expression of CD38 on regulatory T cells by Patton, Daniel T, Wilson, Marcus D, Rowan, Wendy C, Soond, Dalya R, Okkenhaug, Klaus

“…The PI3K pathway has emerged as a key regulator of regulatory T cell (Treg) development and homeostasis and is required for full Treg-mediated suppression. To…”
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The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage by Kitevski-LeBlanc, Julianne, Fradet-Turcotte, Amélie, Kukic, Predrag, Wilson, Marcus D, Portella, Guillem, Yuwen, Tairan, Panier, Stephanie, Duan, Shili, Canny, Marella D, van Ingen, Hugo, Arrowsmith, Cheryl H, Rubinstein, John L, Vendruscolo, Michele, Durocher, Daniel, Kay, Lewis E

“…Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a cascade of events…”
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MultiDsk: a ubiquitin-specific affinity resin by Wilson, Marcus D, Saponaro, Marco, Leidl, Mathias A, Svejstrup, Jesper Q

“…Ubiquitylation is a highly diverse and complex post-translational modification for the regulation of protein function and stability. Studies of ubiquitylation…”
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Reading chromatin signatures after DNA double-strand breaks by Wilson, Marcus D., Durocher, Daniel

“…DNA double-strand breaks (DSBs) are DNA lesions that must be accurately repaired in order to preserve genomic integrity and cellular viability. The response to…”
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Cryo‐electron microscopy of chromatin biology by Wilson, Marcus D., Costa, Alessandro

“…The basic unit of chromatin, the nucleosome core particle (NCP), controls how DNA in eukaryotic cells is compacted, replicated and read. Since its discovery,…”
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Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency by Canny, Marella D, Moatti, Nathalie, Wan, Leo C K, Fradet-Turcotte, Amélie, Krasner, Danielle, Mateos-Gomez, Pedro A, Zimmermann, Michal, Orthwein, Alexandre, Juang, Yu-Chi, Zhang, Wei, Noordermeer, Sylvie M, Seclen, Eduardo, Wilson, Marcus D, Vorobyov, Andrew, Munro, Meagan, Ernst, Andreas, Ng, Timothy F, Cho, Tiffany, Cannon, Paula M, Sidhu, Sachdev S, Sicheri, Frank, Durocher, Daniel

“…Modulation of DNA repair pathway choice by a potent inhibitor of 53BP1 improves the efficiency of homology-dependent genome editing in human and mouse cells…”
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The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions by Murawska, Magdalena, Schauer, Tamas, Matsuda, Atsushi, Wilson, Marcus D., Pysik, Thomas, Wojcik, Felix, Muir, Tom W., Hiraoka, Yasushi, Straub, Tobias, Ladurner, Andreas G.

“…The histone chaperone FACT and histone H2B ubiquitination (H2Bub) facilitate RNA polymerase II (Pol II) passage through chromatin, yet it is not clear how they…”
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BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination by Becker, Jordan R., Clifford, Gillian, Bonnet, Clara, Groth, Anja, Wilson, Marcus D., Chapman, J. Ross

“…Protein ubiquitination at sites of DNA double-strand breaks (DSBs) by RNF168 recruits BRCA1 and 53BP1 1 , 2 , which are mediators of the homologous…”
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The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment by Wapenaar, Hannah, Clifford, Gillian, Rolls, Willow, Pasquier, Moira, Burdett, Hayden, Zhang, Yujie, Deák, Gauri, Zou, Juan, Spanos, Christos, Taylor, Mark R D, Mills, Jacquie, Watson, James A, Kumar, Dhananjay, Clark, Richard, Das, Alakta, Valsakumar, Devisree, Bramham, Janice, Voigt, Philipp, Sproul, Duncan, Wilson, Marcus D

“…DNA methyltransferase 3A (DNMT3A) plays a critical role in establishing and maintaining DNA methylation patterns in vertebrates. Here we structurally and…”
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DNMT3B PWWP mutations cause hypermethylation of heterochromatin by Taglini, Francesca, Kafetzopoulos, Ioannis, Rolls, Willow, Musialik, Kamila Irena, Lee, Heng Yang, Zhang, Yujie, Marenda, Mattia, Kerr, Lyndsay, Finan, Hannah, Rubio-Ramon, Cristina, Gautier, Philippe, Wapenaar, Hannah, Kumar, Dhananjay, Davidson-Smith, Hazel, Wills, Jimi, Murphy, Laura C, Wheeler, Ann, Wilson, Marcus D, Sproul, Duncan

“…The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved by the de novo DNA methyltransferases DNMT3A and…”
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Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment by Ross, Jennifer, McIver, Zak, Lambert, Thomas, Piergentili, Cecilia, Bird, Jasmine Emma, Gallagher, Kelly J, Cruickshank, Faye L, James, Patrick, Zarazúa-Arvizu, Efrain, Horsfall, Louise E, Waldron, Kevin J, Wilson, Marcus D, Mackay, C Logan, Baslé, Arnaud, Clarke, David J, Marles-Wright, Jon

“…Encapsulins are protein nanocompartments that house various cargo enzymes, including a family of decameric ferritin-like proteins. Here, we study a recombinant…”
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