Search Results - "Wilson, Landon S"
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Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition
Published in PloS one (21-12-2017)“…Since dietary polyphenols can have beneficial effects in prevention and treatment of cancer, we tested the hypothesis that breast cancer patients' intestinal…”
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Determination of an Interaction Network between an Extracellular Bacterial Pathogen and the Human Host
Published in mBio (18-06-2019)“…A major gap in understanding infectious diseases is the lack of information about molecular interaction networks between pathogens and the human host. causes…”
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Haemophilus ducreyi Infection Induces Oxidative Stress, Central Metabolic Changes, and a Mixed Pro- and Anti-inflammatory Environment in the Human Host
Published in mBio (20-12-2022)“…Few studies have investigated host-bacterial interactions at sites of infection in humans using transcriptomics and metabolomics. Haemophilus ducreyi causes…”
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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells
Published in Cell communication and signaling (16-09-2021)“…Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1)…”
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Gamma-ray Irradiation of Rodent Diets Alters the Urinary Metabolome in Rats with Chemically Induced Mammary Cancer
Published in Metabolites (01-10-2022)“…In this study, a comparative, untargeted metabolomics approach was applied to compare urinary metabolite profiles of rats fed irradiated and non-irradiated…”
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Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism
Published in Free radical biology & medicine (01-02-2016)“…Platelet aggregation is an essential response to tissue injury and is associated with activation of pro-oxidant enzymes, such as cyclooxygenase, and is also a…”
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Identification and analysis of signaling networks potentially involved in breast carcinoma metastasis to the brain
Published in PloS one (11-07-2011)“…Brain is a common site of breast cancer metastasis associated with significant neurologic morbidity, decreased quality of life, and greatly shortened survival…”
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Effect of Mannan Oligosaccharide Supplementation on Body Weight Gain and Fat Accrual in C57Bl/6J Mice
Published in Obesity (Silver Spring, Md.) (01-05-2010)“…The prevalence of obesity in industrialized societies has become markedly elevated. In contrast, model organism research shows that reducing caloric intake…”
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Vaporized E-Cigarette Liquids Induce Ion Transport Dysfunction in Airway Epithelia
Published in American journal of respiratory cell and molecular biology (01-08-2019)“…Cigarette smoking is associated with chronic obstructive pulmonary disease and chronic bronchitis. Acquired ion transport abnormalities, including cystic…”
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Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics
Published in Scientific reports (09-07-2018)“…Asthma is a chronic inflammatory disease process involving the conductive airways of the human lung. The dysregulated inflammatory response in this disease…”
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Dietary table grape protects against ultraviolet photodamage in humans: 2. molecular biomarker studies
Published in Journal of the American Academy of Dermatology (01-10-2021)Get full text
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Increased flux through the mevalonate pathway mediates fibrotic repair without injury
Published in The Journal of clinical investigation (01-11-2019)“…Macrophages are important in mounting an innate immune response to injury as well as in repair of injury. Gene expression of Rho proteins is known to be…”
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Truncating PKHD1 and PKD2 mutations alter energy metabolism
Published in American journal of physiology. Renal physiology (01-03-2019)“…Deficiency in polycystin 1 triggers specific changes in energy metabolism. To determine whether defects in other human cystoproteins have similar effects, we…”
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Crystal structure of Yersinia pestis virulence factor YfeA reveals two polyspecific metal‐binding sites
Published in Acta crystallographica. Section D, Biological crystallography. (01-07-2017)“…Gram‐negative bacteria use siderophores, outer membrane receptors, inner membrane transporters and substrate‐binding proteins (SBPs) to transport transition…”
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Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women
Published in The Journal of infectious diseases (15-06-2017)“…Chlamydia trachomatis (Ct) infection causes significant morbidity. In vitro studies demonstrate that Ct growth inhibition occurs by interferon-gamma…”
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Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells
Published in Journal of neuropathology and experimental neurology (01-06-2015)“…Neurofibromin, the tumor suppressor encoded by the neurofibromatosis type 1 (NF1) gene, potentially suppresses the activation of H-Ras, N-Ras, and K-Ras…”
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Nicotinamide Adenine Dinucleotide Biosynthetic Impairment and Urinary Metabolomic Alterations Observed in Hospitalized Adults With COVID-19–Related Acute Kidney Injury
Published in Kidney international reports (01-12-2021)“…Acute kidney injury (AKI) is common in COVID-19 and associated with increased morbidity and mortality. We investigated alterations in the urine metabolome to…”
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Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling
Published in Scientific reports (23-01-2017)“…The tumor suppressor protein Merlin is proteasomally degraded in breast cancer. We undertook an untargeted metabolomics approach to discern the global…”
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Endothelial integrin α3β1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macromolecular signaling complex formation at the endothelial cell membrane
Published in Oncotarget (15-03-2014)“…Blood borne metastatic tumor cell adhesion to endothelial cells constitutes a critical rate-limiting step in hematogenous cancer metastasis. Interactions…”
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