Search Results - "Wilson, Katina M."

Hydrogen Peroxide Promotes Aging-Related Platelet Hyperactivation and Thrombosis by DAYAL, Sanjana, WILSON, Katina M, MOTTO, David G, MILLER, Francis J, CHAUHAN, Anil K, LENTZ, Steven R

“…The incidence of thrombotic events increases during aging, but the mechanisms are not well understood. To investigate the prothrombotic role of oxidative…”
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Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis by Jobe, Shawn M., Wilson, Katina M., Leo, Lorie, Raimondi, Alejandro, Molkentin, Jeffery D., Lentz, Steven R., Di Paola, Jorge

“…Many of the cellular responses that occur in activated platelets resemble events that take place following activation of cell-death pathways in nucleated…”
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Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis by Dayal, Sanjana, Gu, Sean X, Hutchins, Ryan D, Wilson, Katina M, Wang, Yi, Fu, Xiaoyun, Lentz, Steven R

“…OBJECTIVE—Clinical evidence suggests an association between oxidative stress and vascular disease, and in vitro studies have demonstrated that reactive oxygen…”
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Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis by Raife, Thomas J, Dwyre, Denis M, Stevens, Jeff W, Erger, Rochelle A, Leo, Lorie, Wilson, Katina M, Fernández, Jose A, Wilder, Jennifer, Kim, Hyung-Suk, Griffin, John H, Maeda, Nobuyo, Lentz, Steven R

“…OBJECTIVE—We sought to develop a murine model to examine the antithrombotic and antiinflammatory functions of human thrombomodulin in vivo. METHODS AND…”
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Extracellular histones: a unifying mechanism driving platelet-dependent extracellular vesicle release and thrombus formation in COVID-19 by Eustes, Alicia S., Ahmed, Azaj, Swamy, Jagadish, Patil, Gokul, Jensen, Melissa, Wilson, Katina M., Kudchadkar, Shibani, Wahab, Abdul, Perepu, Usha, Miller, Francis J., Lentz, Steven R., Dayal, Sanjana

“…COVID-19 can cause profound inflammation and coagulopathy, and while many mechanisms have been proposed, there is no known common pathway leading to a…”
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Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression by Jin, Hong, Gebska, Milena A, Blokhin, Ilya O, Wilson, Katina M, Ketsawatsomkron, Pimonrat, Chauhan, Anil K, Keen, Henry L, Sigmund, Curt D, Lentz, Steven R

“…We tested the hypothesis that endothelial peroxisome proliferator-activated receptor-γ protects against vascular thrombosis using a transgenic mouse model…”
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Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia by Dayal, Sanjana, Wilson, Katina M., Leo, Lorie, Arning, Erland, Bottiglieri, Teodoro, Lentz, Steven R.

“…Hyperhomocysteinemia is a risk factor for thrombosis, but the mechanisms are not well defined. We tested the hypothesis that hyperhomocysteinemia accelerates…”
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Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling by Klutho, Paula J, Pennington, Steven M, Scott, Jason A, Wilson, Katina M, Gu, Sean X, Doddapattar, Prakash, Xie, Litao, Venema, Ashlee N, Zhu, Linda J, Chauhan, Anil K, Lentz, Steven R, Grumbach, Isabella M

“…OBJECTIVE—Emerging evidence suggests that methionine oxidation can directly affect protein function and may be linked to cardiovascular disease. The objective…”
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Protein methionine oxidation augments reperfusion injury in acute ischemic stroke by Gu, Sean X, Blokhin, Ilya O, Wilson, Katina M, Dhanesha, Nirav, Doddapattar, Prakash, Grumbach, Isabella M, Chauhan, Anil K, Lentz, Steven R

“…Reperfusion injury can exacerbate tissue damage in ischemic stroke, but little is known about the mechanisms linking ROS to stroke severity. Here, we tested…”
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Overexpression of Dimethylarginine Dimethylaminohydrolase Protects Against Cerebral Vascular Effects of Hyperhomocysteinemia by Rodionov, Roman N, Dayoub, Hayan, Lynch, Cynthia M, Wilson, Katina M, Stevens, Jeff W, Murry, Daryl J, Kimoto, Masumi, Arning, Erland, Bottiglieri, Teodoro, Cooke, John P, Baumbach, Gary L, Faraci, Frank M, Lentz, Steven R

“…RATIONALE:Hyperhomocysteinemia is a cardiovascular risk factor that is associated with elevation of the nitric oxide synthase inhibitor asymmetrical…”
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Prothrombotic Effects of Hyperhomocysteinemia and Hypercholesterolemia in ApoE-Deficient Mice by Wilson, Katina M, McCaw, Ryan B, Leo, Lorie, Arning, Erland, Lhoták, Šárka, Bottiglieri, Teodoro, Austin, Richard C, Lentz, Steven R

“…OBJECTIVE—We tested the hypothesis that hyperhomocysteinemia and hypercholesterolemia promote arterial thrombosis in mice. METHODS AND RESULTS—Male…”
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Genetic analysis of four novel peroxisome proliferator activated receptor-gamma splice variants in monkey macrophages by Zhou, Jiming, Wilson, Katina M, Medh, Jheem D

“…Peroxisome proliferator activated receptor-gamma (PPAR-gamma) is abundantly expressed in atherosclerotic lesions and is implicated in atherogenesis. The…”
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Mechanisms of the atherogenic effects of elevated homocysteine in experimental models by Wilson, Katina M, Lentz, Steven R

“…Hyperhomocysteinemia is a risk factor for cardiovascular disease and stroke. During the last decade, considerable progress in delineating the mechanisms that…”
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Rebuttal: Need for mechanical ventilation with murine thrombosis models by Wilson, Katina M, Lentz, Steven R

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Abstract MP03: Histone-mediated Platelet Activation And Microvesicle-induced Thrombin Generation In COVID-19 by Eustes, Alicia S, Swamy, Jagadish, jensen, melissa, Wilson, Katina M, Kudchadkar, Shibani M, Perepu, Usha, Miller, Francis J, Lentz, Steven R, Dayal, Sanjana

“…Abstract only Background: Severe COVID-19 leads to inflammation and coagulopathy with progression to multiple organ failure. Several prothrombotic mechanisms…”
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Abstract 54: Overexpression of Glutathione Peroxidase-1 Protects Mice from Aging-Related Enhancement of Experimental Thrombosis and Platelet Activation by Dayal, Sanjana, Wilson, Katina M, Lentz, Steven R

“…Abstract only Despite a well-established clinical association between aging and thrombosis, little is known about the mechanisms by which aging increases…”
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The small‐molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis by Branchford, B. R., Stalker, T. J., Law, L., Acevedo, G., Sather, S., Brzezinski, C., Wilson, K. M., Minson, K., Lee‐Sherick, A. B., Davizon‐Castillo, P., Ng, C., Zhang, W., Neeves, K. B., Lentz, S. R., Wang, X., Frye, S. V., Shelton Earp, H., DeRyckere, D., Brass, L. F., Graham, D. K., Di Paola, J. A.

“…Essentials Signaling by Gas6 through Tyro3/Axl/Mer receptors is essential for stable platelet aggregation. UNC2025 is a small molecule inhibitor of the Mer…”
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Deficiency of Superoxide Dismutase Impairs Generation of Activated Protein C and Enhances Susceptibility to Experimental Thrombosis in Mice by Dayal, Sanjana, Wilson, Katina M, Hutchins, Ryan, Lentz, Steven R.

“…Abstract 535 In vitro studies have suggested that reactive oxygen species such as superoxide can produce several potentially prothrombotic effects, including…”
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Abstract 9: Apelin Protects Against Arterial Thrombosis in Mice with Diet-induced Obesity by Jin, Hong, Wilson, Katina M, Chauhan, Anil K, Tsao, Philip S, Lentz, Steven R

“…Abstract only Background and Hypothesis The prevalence of obesity and related thrombotic diseases is increasing steadily, but the underlying mechanisms of…”
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Deletion of methionine sulfoxide reductase A does not affect atherothrombosis but promotes neointimal hyperplasia and ERK1/2 signaling by Klutho, Paula J., Pennington, Steven M., Scott, Jason A., Wilson, Katina M., Gu, Sean X., Doddapattar, Prakash, Xie, Litao, Venema, Ashlee N., Zhu, Linda J., Chauhan, Anil K., Lentz, Steven R., Grumbach, Isabella M.

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