Search Results - "Wilson, James"

Policy-mix evaluation: Governance challenges from new place-based innovation policies by Magro, Edurne, Wilson, James R.

“…•Verticality, directionality and the capability to foster experimentation are key characteristics of place-based innovation policy-mixes.•Finding the right…”
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Learning, adaptation, and the complexity of human and natural interactions in the ocean by Wilson, James

“…Here, I explore the system-level consequences of learning and adaptation among fish and fishers. The fundamental idea is that the cost of acquiring the…”
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Hypoxia induces rapid changes to histone methylation and reprograms chromatin by Batie, Michael, Frost, Julianty, Frost, Mark, Wilson, James W, Schofield, Pieta, Rocha, Sonia

“…Oxygen is essential for the life of most multicellular organisms. Cells possess enzymes called molecular dioxygenases that depend on oxygen for activity. A…”
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Complex innovation policy systems: Towards an evaluation mix by Magro, Edurne, Wilson, James R.

“…•We ask how policy-makers can approach evaluation in complex systemic contexts.•An innovation policy system is the conjuncture of policy mix and multilevel…”
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Runs of homozygosity: windows into population history and trait architecture by Ceballos, Francisco C., Joshi, Peter K., Clark, David W., Ramsay, Michèle, Wilson, James F.

“…Key Points The inheritance of identical haplotypes from a common ancestor creates long tracts of homozygous genotypes known as runs of homozygosity (ROH). ROH…”
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The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice by Hordeaux, Juliette, Wang, Qiang, Katz, Nathan, Buza, Elizabeth L., Bell, Peter, Wilson, James M.

“…Improved delivery of adeno-associated virus (AAV) vectors to the CNS will greatly enhance their clinical utility. Selection of AAV9 variants in a mouse model…”
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Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial by Somanathan, Suryanarayan, Calcedo, Roberto, Wilson, James M.

“…Intra-arterial administration of an adenovirus serotype 5 (Ad5) vector in a gene therapy trial caused lethal, systemic inflammation in subject 019 with…”
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AAP President's Address by Wilson, James G.

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A general approach for haplotype phasing across the full spectrum of relatedness by O'Connell, Jared, Gurdasani, Deepti, Delaneau, Olivier, Pirastu, Nicola, Ulivi, Sheila, Cocca, Massimiliano, Traglia, Michela, Huang, Jie, Huffman, Jennifer E, Rudan, Igor, McQuillan, Ruth, Fraser, Ross M, Campbell, Harry, Polasek, Ozren, Asiki, Gershim, Ekoru, Kenneth, Hayward, Caroline, Wright, Alan F, Vitart, Veronique, Navarro, Pau, Zagury, Jean-Francois, Wilson, James F, Toniolo, Daniela, Gasparini, Paolo, Soranzo, Nicole, Sandhu, Manjinder S, Marchini, Jonathan

“…Many existing cohorts contain a range of relatedness between genotyped individuals, either by design or by chance. Haplotype estimation in such cohorts is a…”
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Genomic runs of homozygosity record population history and consanguinity by Kirin, Mirna, McQuillan, Ruth, Franklin, Christopher S, Campbell, Harry, McKeigue, Paul M, Wilson, James F

“…The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is…”
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Worldwide Epidemiology of Neutralizing Antibodies to Adeno-Associated Viruses by Calcedo, Roberto, Vandenberghe, Luk H., Gao, Guangping, Lin, Jianping, Wilson, James M.

“…Recombinant adeno-associated viruses (AAVs) have unique gene-transfer properties that speak to their potential as carriers for gene therapy or vaccine…”
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Manipulating microcompartment operons to study mechanism and function by Wilson, James W

“…•Bacterial microcompartment genes are typically organized into large operons.•Microcompartment operons can be engineered and re-organized into synthetic…”
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Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device by Shepherd, Sarah J, Warzecha, Claude C, Yadavali, Sagar, El-Mayta, Rakan, Alameh, Mohamad-Gabriel, Wang, Lili, Weissman, Drew, Wilson, James M, Issadore, David, Mitchell, Michael J

“…A major challenge to advance lipid nanoparticles (LNPs) for RNA therapeutics is the development of formulations that can be produced reliably across the…”
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Lessons learned from the gene therapy trial for ornithine transcarbamylase deficiency by Wilson, James M.

“…It has been 9 years since Mr. Jesse Gelsinger died from complications of vector administration in a liver gene therapy trial of research subjects with a…”
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Humoral Immune Response to AAV by Calcedo, Roberto, Wilson, James M

“…Adeno-associated virus (AAV) is a member of the family Parvoviridae that has been widely used as a vector for gene therapy because of its safety profile, its…”
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Abundant Pleiotropy in Human Complex Diseases and Traits by Sivakumaran, Shanya, Agakov, Felix, Theodoratou, Evropi, Prendergast, James G., Zgaga, Lina, Manolio, Teri, Rudan, Igor, McKeigue, Paul, Wilson, James F., Campbell, Harry

“…We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits. We find…”
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Oxygen‐sensing mechanisms in cells by Wilson, James W., Shakir, Dilem, Batie, Michael, Frost, Mark, Rocha, Sonia

“…The importance of oxygen for the survival of multicellular and aerobic organisms is well established and documented. Over the years, increased knowledge of its…”
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Graphene Nanopores for Protein Sequencing by Wilson, James, Sloman, Leila, He, Zhiren, Aksimentiev, Aleksei

“…An inexpensive, reliable method for protein sequencing is essential to unraveling the biological mechanisms governing cellular behavior and disease. Current…”
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DNA methylation GrimAge strongly predicts lifespan and healthspan by Lu, Ake T, Quach, Austin, Wilson, James G, Reiner, Alex P, Aviv, Abraham, Raj, Kenneth, Hou, Lifang, Baccarelli, Andrea A, Li, Yun, Stewart, James D, Whitsel, Eric A, Assimes, Themistocles L, Ferrucci, Luigi, Horvath, Steve

“…It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be…”
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Geospatial blockchain: promises, challenges, and scenarios in health and healthcare by Kamel Boulos, Maged N, Wilson, James T, Clauson, Kevin A

“…A PubMed query run in June 2018 using the keyword 'blockchain' retrieved 40 indexed papers, a reflection of the growing interest in blockchain among the…”
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