Search Results - "Wilson, Ian A."

Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol by Kadam, Rameshwar U., Wilson, Ian A.

“…The broad-spectrum antiviral drug Arbidol shows efficacy against influenza viruses by targeting the hemagglutinin (HA) fusion machinery. However, the…”
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Exploitation of glycosylation in enveloped virus pathobiology by Watanabe, Yasunori, Bowden, Thomas A., Wilson, Ian A., Crispin, Max

“…Glycosylation is a ubiquitous post-translational modification responsible for a multitude of crucial biological roles. As obligate parasites, viruses exploit…”
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The HIV‐1 envelope glycoprotein structure: nailing down a moving target by Ward, Andrew B, Wilson, Ian A

“…Summary Structure determination of the HIV‐1 envelope glycoprotein (Env) presented a number of challenges, but several high‐resolution structures have now…”
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Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies by Yuan, Meng, Liu, Hejun, Wu, Nicholas C., Wilson, Ian A.

“…Immediately from the outset of the COVID-19 pandemic, researchers from diverse biomedical and biological disciplines have united to study the novel pandemic…”
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A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus by Wu, Nicholas C., Wilson, Ian A.

“…Influenza virus evolves rapidly to constantly escape from natural immunity. Most humoral immune responses to influenza virus target the hemagglutinin (HA)…”
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A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV by Yuan, Meng, Wu, Nicholas C, Zhu, Xueyong, Lee, Chang-Chun D, So, Ray T Y, Lv, Huibin, Mok, Chris K P, Wilson, Ian A

“…The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there…”
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Structural basis of a shared antibody response to SARS-CoV-2 by Yuan, Meng, Liu, Hejun, Wu, Nicholas C, Lee, Chang-Chun D, Zhu, Xueyong, Zhao, Fangzhu, Huang, Deli, Yu, Wenli, Hua, Yuanzi, Tien, Henry, Rogers, Thomas F, Landais, Elise, Sok, Devin, Jardine, Joseph G, Burton, Dennis R, Wilson, Ian A

“…Molecular understanding of neutralizing antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could accelerate vaccine design and…”
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Structure and Immune Recognition of the HIV Glycan Shield by Crispin, Max, Ward, Andrew B, Wilson, Ian A

“…Vaccine design efforts against the human immunodeficiency virus (HIV) have been greatly stimulated by the observation that many infected patients eventually…”
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Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers by Blattner, Claudia, Lee, Jeong Hyun, Sliepen, Kwinten, Derking, Ronald, Falkowska, Emilia, de la Peña, Alba Torrents, Cupo, Albert, Julien, Jean-Philippe, van Gils, Marit, Lee, Peter S., Peng, Wenjie, Paulson, James C., Poignard, Pascal, Burton, Dennis R., Moore, John P., Sanders, Rogier W., Wilson, Ian A., Ward, Andrew B.

“…All previously characterized broadly neutralizing antibodies to the HIV-1 envelope glycoprotein (Env) target one of four major sites of vulnerability. Here, we…”
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Vulnerabilities in coronavirus glycan shields despite extensive glycosylation by Watanabe, Yasunori, Berndsen, Zachary T., Raghwani, Jayna, Seabright, Gemma E., Allen, Joel D., Pybus, Oliver G., McLellan, Jason S., Wilson, Ian A., Bowden, Thomas A., Ward, Andrew B., Crispin, Max

“…Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses (CoVs) are zoonotic pathogens with high fatality rates and…”
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Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model by Rogers, Thomas F, Zhao, Fangzhu, Huang, Deli, Beutler, Nathan, Burns, Alison, He, Wan-Ting, Limbo, Oliver, Smith, Chloe, Song, Ge, Woehl, Jordan, Yang, Linlin, Abbott, Robert K, Callaghan, Sean, Garcia, Elijah, Hurtado, Jonathan, Parren, Mara, Peng, Linghang, Ramirez, Sydney, Ricketts, James, Ricciardi, Michael J, Rawlings, Stephen A, Wu, Nicholas C, Yuan, Meng, Smith, Davey M, Nemazee, David, Teijaro, John R, Voss, James E, Wilson, Ian A, Andrabi, Raiees, Briney, Bryan, Landais, Elise, Sok, Devin, Jardine, Joseph G, Burton, Dennis R

“…Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory…”
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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants by Yuan, Meng, Huang, Deli, Lee, Chang-Chun D, Wu, Nicholas C, Jackson, Abigail M, Zhu, Xueyong, Liu, Hejun, Peng, Linghang, van Gils, Marit J, Sanders, Rogier W, Burton, Dennis R, Reincke, S Momsen, Prüss, Harald, Kreye, Jakob, Nemazee, David, Ward, Andrew B, Wilson, Ian A

“…Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike protein of wild-type severe acute respiratory syndrome coronavirus…”
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Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10 by Irimia, Adriana, Sarkar, Anita, Stanfield, Robyn L., Wilson, Ian A.

“…Numerous studies of the anti-HIV-1 envelope glycoprotein 41 (gp41) broadly neutralizing antibody 4E10 suggest that 4E10 also interacts with membrane lipids,…”
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Integrative Structural Biology by Ward, Andrew B., Sali, Andrej, Wilson, Ian A.

“…Integrative approaches using data from a wide variety of methods are yielding model structures of complex biological assemblies. Biological assemblies and…”
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Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse Viruses by Burton, Dennis R., Poignard, Pascal, Stanfield, Robyn L., Wilson, Ian A.

“…Certain human pathogens avoid elimination by our immune system by rapidly mutating the surface protein sites targeted by antibody responses, and consequently…”
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New world bats harbor diverse influenza A viruses by Tong, Suxiang, Zhu, Xueyong, Li, Yan, Shi, Mang, Zhang, Jing, Bourgeois, Melissa, Yang, Hua, Chen, Xianfeng, Recuenco, Sergio, Gomez, Jorge, Chen, Li-Mei, Johnson, Adam, Tao, Ying, Dreyfus, Cyrille, Yu, Wenli, McBride, Ryan, Carney, Paul J, Gilbert, Amy T, Chang, Jessie, Guo, Zhu, Davis, Charles T, Paulson, James C, Stevens, James, Rupprecht, Charles E, Holmes, Edward C, Wilson, Ian A, Donis, Ruben O

“…Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype…”
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Design of protein-binding proteins from the target structure alone by Cao, Longxing, Coventry, Brian, Goreshnik, Inna, Huang, Buwei, Sheffler, William, Park, Joon Sung, Jude, Kevin M., Marković, Iva, Kadam, Rameshwar U., Verschueren, Koen H. G., Verstraete, Kenneth, Walsh, Scott Thomas Russell, Bennett, Nathaniel, Phal, Ashish, Yang, Aerin, Kozodoy, Lisa, DeWitt, Michelle, Picton, Lora, Miller, Lauren, Strauch, Eva-Maria, DeBouver, Nicholas D., Pires, Allison, Bera, Asim K., Halabiya, Samer, Hammerson, Bradley, Yang, Wei, Bernard, Steffen, Stewart, Lance, Wilson, Ian A., Ruohola-Baker, Hannele, Schlessinger, Joseph, Lee, Sangwon, Savvides, Savvas N., Garcia, K. Christopher, Baker, David

“…The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the…”
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Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine Immunogens by Zost, Seth J, Wu, Nicholas C, Hensley, Scott E, Wilson, Ian A

“…Abstract Influenza viruses routinely acquire mutations in their hemagglutinin (HA) and neuraminidase (NA) glycoproteins that abrogate binding of pre-existing…”
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A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface by Bangaru, Sandhya, Lang, Shanshan, Schotsaert, Michael, Vanderven, Hillary A., Zhu, Xueyong, Kose, Nurgun, Bombardi, Robin, Finn, Jessica A., Kent, Stephen J., Gilchuk, Pavlo, Gilchuk, Iuliia, Turner, Hannah L., García-Sastre, Adolfo, Li, Sheng, Ward, Andrew B., Wilson, Ian A., Crowe, James E.

“…Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA)…”
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