Search Results - "Wilson, Heather L"
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Conformational dynamics of α-synuclein and study of its intramolecular forces in the presence of selected compounds
Published in Scientific reports (03-11-2023)“…Protein misfolding and aggregation play crucial roles in amyloidogenic diseases through the self-assembly of intrinsically disordered proteins (IDPs) in type…”
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Understanding GroEL and DnaK Stress Response Proteins as Antigens for Bacterial Diseases
Published in Vaccines (Basel) (17-12-2020)“…Bacteria do not simply express a constitutive panel of proteins but they instead undergo dynamic changes in their protein repertoire in response to changes in…”
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Markers of the ageing macrophage: a systematic review and meta-analysis
Published in Frontiers in immunology (13-07-2023)“…Ageing research is establishing macrophages as key immune system regulators that undergo functional decline. Due to heterogeneity between species and tissue…”
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4
Regulating STING in health and disease
Published in Journal of inflammation (London, England) (07-06-2017)“…The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an…”
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Immune responses in the uterine mucosa: clues for vaccine development in pigs
Published in Frontiers in immunology (07-07-2023)“…The immune system in the upper reproductive tract (URT) protects against sexually transmitted pathogens, while at the same time providing immune tolerance…”
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Human Neural Larva Migrans Caused by Ophidascaris robertsi Ascarid
Published in Emerging infectious diseases (01-09-2023)“…We describe a case in Australia of human neural larva migrans caused by the ascarid Ophidascaris robertsi, for which Australian carpet pythons are definitive…”
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tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis
Published in Nature communications (13-02-2019)“…Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour of endothelial cells (ECs) as they form vascular networks. Vascular…”
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Evidence for a common mucosal immune system in the pig
Published in Molecular immunology (01-07-2015)“…•There is evidence that the common mucosal immune system exists in pigs.•Vaccination at an easily accessible mucosal site may assist in providing protection at…”
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Experimental natural transmission (seeder pig) models for reproduction of swine dysentery
Published in PloS one (27-09-2022)“…Swine dysentery is causally associated with Brachyspira hampsonii and B . hyodysenteriae infection. Given the importance of transmission models in…”
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Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
Published in Cell reports (Cambridge) (23-04-2024)“…Macrophages are central innate immune cells whose function declines with age. The molecular mechanisms underlying age-related changes remain poorly understood,…”
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Tribbles-1 Expression and Its Function to Control Inflammatory Cytokines, Including Interleukin-8 Levels are Regulated by miRNAs in Macrophages and Prostate Cancer Cells
Published in Frontiers in immunology (27-11-2020)“…The pseudokinase controls cell function in a range of contexts, by regulating MAP kinase activation and mediating protein degradation the COP1 ubiquitin…”
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In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection
Published in PLoS pathogens (09-07-2020)“…Reactive arthritis, an autoimmune disorder, occurs following gastrointestinal infection with invasive enteric pathogens, such as Salmonella enterica. Curli, an…”
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13
Expression of pattern recognition receptors in porcine uterine epithelial cells in vivo and in culture
Published in Veterinary immunology and immunopathology (01-08-2018)“…•A number of pattern recognition receptors are expressed by porcine uterine epithelial cells.•TLR3 and TLR9 localize to the apical cell membrane and TLR4…”
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14
Myocarditis Caused by Human Parechovirus in Adult
Published in Emerging infectious diseases (01-09-2017)“…The infectious etiology of myocarditis often remains unidentified. We report a case of myocarditis associated with human parechovirus (HPeV) infection in an…”
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Development of flow cytometry based adherence assay for Neisseria gonorrhoeae using 5'-carboxyfluorosceinsuccidyl ester
Published in BMC microbiology (25-03-2019)“…Neisseria gonorrhoeae is an obligate human pathogen and its adherence to host cells is essential for its pathogenesis. Gonococcal adherence assays are based on…”
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16
Zebrafish tissue injury causes upregulation of interleukin-1 and caspase-dependent amplification of the inflammatory response
Published in Disease models & mechanisms (01-02-2014)“…Interleukin-1 (IL-1), the 'gatekeeper' of inflammation, is the apical cytokine in a signalling cascade that drives the early response to injury or infection…”
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Polyphosphazenes as Adjuvants for Animal Vaccines and Other Medical Applications
Published in Frontiers in bioengineering and biotechnology (04-03-2021)“…Polyphosphazenes are a class of experimental adjuvants that have shown great versatility as vaccine adjuvants in many animal species ranging from laboratory…”
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Assessment of Immunological Response and Impacts on Fertility Following Intrauterine Vaccination Delivered to Swine in an Artificial Insemination Dose
Published in Frontiers in immunology (27-05-2020)“…To protect the health of sows and gilts, significant investments are directed toward the development of vaccines against infectious agents that impact…”
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Rearing pigs with play opportunities: the effects on disease resilience in pigs experimentally inoculated with PRRSV
Published in Frontiers in veterinary science (17-09-2024)“…Positive emotions can reduce disease susceptibility during infectious challenges in humans, and emerging evidence suggests similar effects in farm animals…”
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A Modular, Tn7-Based System for Making Bioluminescent or Fluorescent Salmonella and Escherichia coli Strains
Published in Applied and environmental microbiology (15-08-2016)“…Our goal was to develop a robust tagging method that can be used to track bacterial strains in vivo To address this challenge, we adapted two existing systems:…”
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