Search Results - "Wilson, Frederick J."

A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor by Maher, Toby M, Simpson, Juliet K, Porter, Joanna C, Wilson, Frederick J, Chan, Robert, Eames, Rhena, Cui, Yi, Siederer, Sarah, Parry, Simon, Kenny, Julia, Slack, Robert J, Sahota, Jagdeep, Paul, Lyn, Saunders, Peter, Molyneaux, Philip L, Lukey, Pauline T, Rizzo, Gaia, Searle, Graham E, Marshall, Richard P, Saleem, Azeem, Kang'ombe, Arthur R, Fairman, David, Fahy, William A, Vahdati-Bolouri, Mitra

“…Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the…”
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Quantification of Lung PET Images: Challenges and Opportunities by Chen, Delphine L, Cheriyan, Joseph, Chilvers, Edwin R, Choudhury, Gourab, Coello, Christopher, Connell, Martin, Fisk, Marie, Groves, Ashley M, Gunn, Roger N, Holman, Beverley F, Hutton, Brian F, Lee, Sarah, MacNee, William, Mohan, Divya, Parr, David, Subramanian, Deepak, Tal-Singer, Ruth, Thielemans, Kris, van Beek, Edwin J R, Vass, Laurence, Wellen, Jeremy W, Wilkinson, Ian, Wilson, Frederick J

“…Millions of people are affected by respiratory diseases, leading to a significant health burden globally. Because of the current insufficient knowledge of the…”
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Guidelines for the recording and evaluation of pharmaco-EEG data in man: the International Pharmaco-EEG Society (IPEG) by Jobert, Marc, Wilson, Frederick J, Ruigt, Gé S F, Brunovsky, Martin, Prichep, Leslie S, Drinkenburg, Wilhelmus H I M

“…The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of…”
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Reproducibility of compartmental modelling of 18F-FDG PET/CT to evaluate lung inflammation by Vass, Laurence D., Lee, Sarah, Wilson, Frederick J., Fisk, Marie, Cheriyan, Joseph, Wilkinson, Ian

“…Introduction Compartmental modelling is an established method of quantifying 18 F-FDG uptake; however, only recently has it been applied to evaluate pulmonary…”
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Guidelines for the recording and evaluation of pharmaco-sleep studies in man: the International Pharmaco-EEG Society (IPEG) by Jobert, Marc, Wilson, Frederick J, Roth, Thomas, Ruigt, Gé S F, Anderer, Peter, Drinkenburg, Wilhelmus H I M, Bes, Frederik W, Brunovsky, Martin, Danker-Hopfe, Heidi, Freeman, Jon, van Gerven, Joop M A, Gruber, Georg, Kemp, Bob, Klösch, Gerhard, Ma, Junshui, Penzel, Thomas, Peterson, Barry T, Schulz, Hartmut, Staner, Luc, Saletu, Bernd, Svetnik, Vladimir

“…The International Pharmaco-EEG Society (IPEG) presents guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-sleep…”
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Sensitivity analysis of models of gas exchange for lung hyperpolarised 129 Xe MR by Taylor, Yohn, Wilson, Frederick J, Kim, Mina, Parker, Geoff J M

“…Sensitivity analysis enables the identification of influential parameters and the optimisation of model composition. Such methods have not previously been…”
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Sensitivity analysis of models of gas exchange for lung hyperpolarised 129Xe MR by Taylor, Yohn, Wilson, Frederick J., Kim, Mina, Parker, Geoff J. M.

“…Sensitivity analysis enables the identification of influential parameters and the optimisation of model composition. Such methods have not previously been…”
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Quantification of the αvβ6 Integrin by PET/CT Imaging in the Lungs of Patients After SARS-CoV2 Infection and Comparison to Fibrotic Lungs by Lukey, Pauline T, Wilson, Frederick J

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Quantification of the α v β 6 Integrin by PET/CT Imaging in the Lungs of Patients After SARS-CoV2 Infection and Comparison to Fibrotic Lungs by Lukey, Pauline T, Wilson, Frederick J

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Advances in PET to assess pulmonary inflammation: A systematic review by Vass, Laurence, Fisk, Marie, Lee, Sarah, Wilson, Frederick J., Cheriyan, Joseph, Wilkinson, Ian

“…•This systematic review identifies the current status of PET to assess inflammatory lung disease and speculates on its future direction.•Although FDG is the…”
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A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis by Lukey, Pauline T, Harrison, Stephen A, Yang, Shuying, Man, Yim, Holman, Beverley F, Rashidnasab, Alaleh, Azzopardi, Gabrielle, Grayer, Michael, Simpson, Juliet K, Bareille, Philippe, Paul, Lyn, Woodcock, Hannah V, Toshner, Richard, Saunders, Peter, Molyneaux, Philip L, Thielemans, Kris, Wilson, Frederick J, Mercer, Paul F, Chambers, Rachel C, Groves, Ashley M, Fahy, William A, Marshall, Richard P, Maher, Toby M

“…Phosphatidylinositol 3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF)…”
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Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation by Coello, Christopher, Fisk, Marie, Mohan, Divya, Wilson, Frederick J., Brown, Andrew P., Polkey, Michael I., Wilkinson, Ian, Tal-Singer, Ruth, Murphy, Philip S., Cheriyan, Joseph, Gunn, Roger N.

“…Background An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients…”
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Validity of physical activity monitors during daily life in patients with COPD by RABINOVICH, Roberto A, LOUVARIS, Zafeiris, POLKEY, Michael I, WILSON, Frederick J, MACNEE, William, WESTERTERP, Klaas R, TROOSTERS, Thierry, RASTE, Yogini, LANGER, Daniel, VAN REMOORTEL, Hans, GIAVEDONI, Santiago, BURTIN, Chris, REGUEIRO, Eloisa M. G, VOGIATZIS, Ioannis, HOPKINSON, Nicholas S

“…Symptoms during physical activity and physical inactivity are hallmarks of chronic obstructive pulmonary disease (COPD). Our aim was to evaluate the validity…”
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Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study) by Lukey, Pauline T., Coello, Christopher, Gunn, Roger, Parker, Christine, Wilson, Frederick J., Saleem, Azeem, Garman, Nadia, Costa, Maria, Kendrick, Stuart, Onega, Mayca, Kang’ombe, Arthur R., Listanco, Allan, Davies, James, Ramada-Magalhaes, Joaquim, Moz, Sara, Fahy, William A., Maher, Toby M., Jenkins, Gisli, Passchier, Jan, Marshall, Richard P.

“…Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study…”
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Longitudinal Lung Function Assessment of Patients Hospitalized With COVID-19 Using 1H and 129Xe Lung MRI by Saunders, Laura C., Collier, Guilhem J., Chan, Ho-Fung, Hughes, Paul J.C., Smith, Laurie J., Watson, J.G.R., Meiring, James E., Gabriel, Zoë, Newman, Thomas, Plowright, Megan, Wade, Phillip, Eaden, James A., Thomas, Siby, Strickland, Scarlett, Gustafsson, Lotta, Bray, Jody, Marshall, Helen, Capener, David A., Armstrong, Leanne, Rodgers, Jennifer, Brook, Martin, Biancardi, Alberto M., Rao, Madhwesha R., Norquay, Graham, Rodgers, Oliver, Munro, Ryan, Ball, James E., Stewart, Neil J., Lawrie, Allan, Jenkins, R. Gisli, Grist, James T., Gleeson, Fergus, Schulte, Rolf F., Johnson, Kevin M., Wilson, Frederick J., Cahn, Anthony, Swift, Andrew J., Rajaram, Smitha, Mills, Gary H., Watson, Lisa, Collini, Paul J., Lawson, Rod, Thompson, A.A. Roger, Wild, Jim M.

“…BACKGROUNDMicrovascular abnormalities and impaired gas transfer have been observed in patients with COVID-19. The progression of pulmonary changes in these…”
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Advanced Analysis of Pharmaco-EEG Data in Humans by Jobert, Marc, Wilson, Frederick J

“…Pharmaco-electroencephalography (EEG) is a non-invasive method used to assess the effects of pharmacological compounds on the central nervous system by…”
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Learning to identify CNS drug action and efficacy using multistudy fMRI data by Duff, Eugene P, Vennart, William, Wise, Richard G, Howard, Matthew A, Harris, Richard E, Lee, Michael, Wartolowska, Karolina, Wanigasekera, Vishvarani, Wilson, Frederick J, Whitlock, Mark, Tracey, Irene, Woolrich, Mark W, Smith, Stephen M

“…The therapeutic effects of centrally acting pharmaceuticals can manifest gradually and unreliably in patients, making the drug discovery process slow and…”
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Early Decision-Making in Drug Development: The Potential Role of Pharmaco-EEG and Pharmaco-Sleep by Wilson, Frederick J, Danjou, Philippe

“…The pharmaceutical industry has been suffering from low clinical success rates of new drugs for some time with particularly high attrition in early clinical…”
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The PROactive innovative conceptual framework on physical activity by DOBBELS, Fabienne, DE JONG, Corina, VAN DER MOLEN, Thys, WILLIAMS, Kate, PINNOCK, Hillary, TROOSTERS, Thierry, KARLSSON, Niklas, KULICH, Karoly, RÜDELL, Katja, DROST, Ellen, ELBERSE, Janneke, FERIDOU, Chryssoula, JACOBS, Laura, RABINOVICH, Roberto, FREI, Anja, PUHAN, Milo A, DE BOER, Willem I

“…Although physical activity is considered an important therapeutic target in chronic obstructive pulmonary disease (COPD), what "physical activity" means to…”
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Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung by Onega, Mayca, Parker, Christine A., Coello, Christopher, Rizzo, Gaia, Keat, Nicholas, Ramada-Magalhaes, Joaquim, Moz, Sara, Tang, Sac-Pham, Plisson, Christophe, Wells, Lisa, Ashworth, Sharon, Slack, Robert J., Vitulli, Giovanni, Wilson, Frederick J., Gunn, Roger, Lukey, Pauline T., Passchier, Jan

“…Purpose Integrin α v β 6 belongs to the RGD subset of the integrin family, and its expression levels are a prognostic and theranostic factor in some types of…”
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