Search Results - "Wilson, Eric A"

Structural insights into the modulation of coronavirus spike tilting and infectivity by hinge glycans by Chmielewski, David, Wilson, Eric A., Pintilie, Grigore, Zhao, Peng, Chen, Muyuan, Schmid, Michael F., Simmons, Graham, Wells, Lance, Jin, Jing, Singharoy, Abhishek, Chiu, Wah

“…Coronavirus spike glycoproteins presented on the virion surface mediate receptor binding, and membrane fusion during virus entry and constitute the primary…”
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Utility of a Telephone Triage Hotline in Response to the COVID-19 Pandemic: Longitudinal Observational Study by Cher, Benjamin A Y, Wilson, Eric A, Pinsky, Alexa M, Townshend, Ryan F, Wolski, Ann V, Broderick, Michael, Milen, Allison M, Lau, Audrey, Singh, Amrit, Cinti, Sandro K, Engelke, Carl G, Saha, Anjan K

“…During the initial months of the COVID-19 pandemic, rapidly rising disease prevalence in the United States created a demand for patient-facing information…”
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Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling by Chen, Min, Wilson, Eric A., Cui, Zhenzhong, Sun, Hui, Shrestha, Yogendra B., Podyma, Brandon, Le, Christina H., Naglieri, Benedetta, Pacak, Karel, Gavrilova, Oksana, Weinstein, Lee S.

“…Gsα couples multiple receptors, including the melanocortin 4 receptor (MC4R), to intracellular cAMP generation. Germline inactivating Gsα mutations lead to…”
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Histology education in an integrated, time‐restricted medical curriculum: Academic outcomes and students' study adaptations by Gribbin, William, Wilson, Eric A., McTaggart, Suzy, Hortsch, Michael

“…In an ever‐changing medical curricular environment, time dedicated for anatomical education has been progressively reduced. This happened at the University of…”
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The stimulatory G protein Gsα is required in melanocortin 4 receptor–expressing cells for normal energy balance, thermogenesis, and glucose metabolism by Podyma, Brandon, Sun, Hui, Wilson, Eric A., Carlson, Bradley, Pritikin, Ethan, Gavrilova, Oksana, Weinstein, Lee S., Chen, Min

“…Central melanocortin 4 receptors (MC4Rs) stimulate energy expenditure and inhibit food intake. MC4Rs activate the G protein Gsα, but whether Gsα mediates all…”
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An immunogenetic basis for lung cancer risk by Krishna, Chirag, Tervi, Anniina, Saffern, Miriam, Wilson, Eric A, Yoo, Seong-Keun, Mars, Nina, Roudko, Vladimir, Cho, Byuri Angela, Jones, Samuel Edward, Vaninov, Natalie, Selvan, Myvizhi Esai, Gümüş, Zeynep H, Lenz, Tobias L, Merad, Miriam, Boffetta, Paolo, Martínez-Jiménez, Francisco, Ollila, Hanna M, Samstein, Robert M, Chowell, Diego

“…Cancer risk is influenced by inherited mutations, DNA replication errors, and environmental factors. However, the influence of genetic variation in…”
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Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations by Chen, Min, Shrestha, Yogendra B, Podyma, Brandon, Cui, Zhenzhong, Naglieri, Benedetta, Sun, Hui, Ho, Thuy, Wilson, Eric A, Li, Yong-Qi, Gavrilova, Oksana, Weinstein, Lee S

“…Gsα, encoded by Gnas, mediates hormone and neurotransmitter receptor-stimulated cAMP generation. Heterozygous Gsα-inactivating mutations lead to obesity in…”
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G q α/G 11 α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity by Wilson, Eric A, Sun, Hui, Cui, Zhenzhong, Jahnke, Marshal T, Pandey, Mritunjay, Metzger, Peter, Gavrilova, Oksana, Chen, Min, Weinstein, Lee S

“…The G-protein subunits G α and G α (G α) couple receptors to phospholipase C, leading to increased intracellular calcium. In this study we investigated the…”
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Total predicted MHC-I epitope load is inversely associated with population mortality from SARS-CoV-2 by Wilson, Eric A., Hirneise, Gabrielle, Singharoy, Abhishek, Anderson, Karen S.

“…Polymorphisms in MHC-I protein sequences across human populations significantly affect viral peptide binding capacity, and thus alter T cell immunity to…”
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High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter by Ray, Shamayeeta, Berry, Samuel P, Wilson, Eric A, Zhang, Casey H, Shekhar, Mrinal, Singharoy, Abhishek, Gaudet, Rachelle

“…Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By…”
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Weakly immunogenic CRISPR therapies by Wilson, Eric A., Anderson, Karen S.

“…Orthologues of CRISPR-associated proteins and of viral vectors evade immune recognition in mice, enabling repeated gene therapy…”
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Resolving the Connection between Major Histocompatibilty Complexes and Immune Outcomes using Unsupervised Clustering of Molecular Dynamics Simulations by Wilson, Eric A., Anderson, Karen, Singharoy, Abhishek

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HLA-Inception: A structure-based deep learning framework for MHC-I binding motif prediction by Wilson, Eric A, Cava, John, Anderson, Karen, Singharoy, Abhishek

“…The ability to accurately identify peptide ligands for a given major histocompatibility complex class I (MHC-I) molecule has immense value for targeted…”
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Identifying highly conserved and immunogenic SARS-CoV-2 CD8+ T Cell Epitopes for Vaccine Design by Carmona, Jacqueline, Wilson, Eric A, Yuvaraj, Padhmavathy, Ulrich, Peaches R, Singharoy, Abhishek, Anderson, Karen S

“…Vaccines to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induce antibody responses against the spike (S) protein. However, the continued…”
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A Random Forest based approach to MHC class I epitope prediction and analysis by Wilson, Eric A., Krishna, Sri, Anderson, Karen S.

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Abstract 5376: Protein structure-based modeling to improve MHC class I epitope predictions by Wilson, Eric A., Cava, John Kevin, Chowell, Diego, Singharoy, Abhishek, Anderson, Karen S.

“…The ability to accurately identify peptide ligands for a given major histocompatibility complex class I (MHC-I) molecule has immense value for targeted…”
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High-resolution structures with bound Mn 2+ and Cd 2+ map the metal import pathway in an Nramp transporter by Ray, Shamayeeta, Berry, Samuel P, Wilson, Eric A, Zhang, Casey H, Shekhar, Mrinal, Singharoy, Abhishek, Gaudet, Rachelle

“…Transporters of the Nramp (Natural resistance-associated macrophage protein) family import divalent transition metal ions into cells of most organisms. By…”
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G sub( s) alpha deficiency in the dorsomedial hypothalamus underlies obesity associated with G sub( s) alpha mutations by Chen, Min, Shrestha, Yogendra B, Podyma, Brandon, Cui, Zhenzhong, Naglieri, Benedetta, Sun, Hui, Ho, Thuy, Wilson, Eric A, Li, Yong-Qi, Gavrilova, Oksana, Weinstein, Lee S

“…Gsa, encoded by Gnas, mediates hormone and neurotransmitter receptor-stimulated cAMP generation. Heterozygous Gsainactivating mutations lead to obesity in…”
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G^sub s^[alpha] deficiency in the dorsomedial hypothalamus underlies obesity associated with G^sub s^[alpha] mutations by Chen, Min, Shrestha, Yogendra B, Podyma, Brandon, Cui, Zhenzhong, Naglieri, Benedetta, Sun, Hui, Ho, Thuy, Wilson, Eric A, Li, Yong-Qi, Gavrilova, Oksana, Weinstein, Lee S

“…Gsa, encoded by Gnas, mediates hormone and neurotransmitter receptor-stimulated cAMP generation. Heterozygous Gsainactivating mutations lead to obesity in…”
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α deficiency in the dorsomedial hypothalamus underlies obesity associated with [G.sub.s]α mutations by Chen, Min, Shrestha, Yogendra B, Podyma, Brandon, Cui, Zhenzhong, Naglieri, Benedetta, Sun, Hui, Ho, Thuy, Wilson, Eric A, Li, Yong-Qi, Gavrilova, Oksana, Weinstein, Lee S

“…[G.sub.s]α, encoded by Gnas, mediates hormone and neurotransmitter receptor-stimulated cAMP generation. Heterozygous [G.sub.s]α-inactivating mutations lead to…”
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