Search Results - "Wilson, Claire H"

Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism by Wilson, Claire H, Ali, Eunüs S, Scrimgeour, Nathan, Martin, Alyce M, Hua, Jin, Tallis, George A, Rychkov, Grigori Y, Barritt, Greg J

“…Lipid accumulation in hepatocytes can lead to non-alcoholic fatty liver disease (NAFLD), which can progress to non-alcoholic steatohepatitis (NASH) and Type 2…”
Get more information

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice by Puccini, Joseph, Shalini, Sonia, Voss, Anne K., Gatei, Magtouf, Wilson, Claire H., Hiwase, Devendra K., Lavin, Martin F., Dorstyn, Loretta, Kumar, Sharad

“…Caspase-2, the most evolutionarily conserved member of the caspase family, has been shown to be involved in apoptosis induced by various stimuli. Our recent…”
Get full text

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism by Wilson, Claire H., Indarto, Dono, Doucet, Alain, Pogson, Lisa D., Pitman, Melissa R., McNicholas, Kym, Menz, R. Ian, Overall, Christopher M., Abbott, Catherine A.

“…Dipeptidyl peptidases (DP) 8 and 9 are homologous, cytoplasmic N-terminal post-proline-cleaving enzymes that are anti-targets for the development of DP4…”
Get full text

Caspases in metabolic disease and their therapeutic potential by Wilson, Claire H, Kumar, Sharad

“…Caspases, a family of cysteine-dependent aspartate-specific proteases, are central to the maintenance of cellular and organismal homoeostasis by functioning as…”
Get full text

Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIP™ DNA microarray by Kappelhoff, Reinhild, Puente, Xose S., Wilson, Claire H., Seth, Arun, López-Otín, Carlos, Overall, Christopher M.

“…The protease degradome is defined as the complete repertoire of proteases and inhibitors, and their nonfunctional homologs present in a cell, tissue or…”
Get full text

The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca(2+) signalling in steatotic hepatocytes by Ali, Eunüs S, Hua, Jin, Wilson, Claire H, Tallis, George A, Zhou, Fiona H, Rychkov, Grigori Y, Barritt, Greg J

“…The release of Ca(2+) from the endoplasmic reticulum (ER) and subsequent replenishment of ER Ca(2+) by Ca(2+) entry through store-operated Ca(2+) channels…”
Get more information

Dipeptidyl peptidase 9 substrates and their discovery: current progress and the application of mass spectrometry-based approaches by Wilson, Claire H, Zhang, Hui Emma, Gorrell, Mark D, Abbott, Catherine A

“…The enzyme members of the dipeptidyl peptidase 4 (DPP4) gene family have the very unusual capacity to cleave the post-proline bond to release dipeptides from…”
Get more information

Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines by WILSON, CLAIRE H, ABBOTT, CATHERINE A

“…Proteases, particularly serine proteases like dipeptidyl peptidase 4 (DP4) and fibroblast activation protein (FAP), play an important role in cancer invasion…”
Get full text

Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity by Wilson, Claire H, Nikolic, Andrej, Kentish, Stephen J, Keller, Marianne, Hatzinikolas, George, Dorstyn, Loretta, Page, Amanda J, Kumar, Sharad

“…Caspase-2 has been shown to be involved in metabolic homeostasis. Here, we show that caspase-2 deficiency alters basal energy metabolism by shifting the…”
Get full text

Increased expression of peroxiredoxin 1 and identification of a novel lipid-metabolizing enzyme in the early phase of liver ischemia reperfusion injury by Wilson, Claire H., Zeile, Susanne, Chataway, Tim, Nieuwenhuijs, Vincent B., Padbury, Robert T. A., Barritt, Greg J.

“…Warm ischemia reperfusion (IR) injury of the liver is associated with changes in the expression and/or post‐translational modification of numerous proteins…”
Get full text

The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca2+ signalling in steatotic hepatocytes by Ali, Eunüs S., Hua, Jin, Wilson, Claire H., Tallis, George A., Zhou, Fiona H., Rychkov, Grigori Y., Barritt, Greg J.

“…The release of Ca2+ from the endoplasmic reticulum (ER) and subsequent replenishment of ER Ca2+ by Ca2+ entry through store-operated Ca2+ channels (SOCE) play…”
Get full text

The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca 2+ signalling in steatotic hepatocytes by Ali, Eunüs S., Hua, Jin, Wilson, Claire H., Tallis, George A., Zhou, Fiona H., Rychkov, Grigori Y., Barritt, Greg J.

Get full text

Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8 by Ajami, Katerina, Pitman, Melissa R., Wilson, Claire H., Park, Joohong, Menz, R. Ian, Starr, Amanda E., Cox, Jennifer H., Abbott, Catherine A., Overall, Christopher M., Gorrell, Mark D.

“…N-terminal truncation of chemokines by proteases including dipeptidyl peptidase (DP) IV significantly alters their biological activity; generally ablating…”
Get full text

Corrigendum to “Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8” [FEBS Lett. 582 (2008) 819–825] by Ajami, Katerina, Pitman, Melissa R., Wilson, Claire H., Park, Joohong, Menz, R. Ian, Starr, Amanda E., Cox, Jennifer H., Abbott, Catherine A., Overall, Christopher M., Gorrell, Mark D.

Get full text

Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8 by Ajami, Katerina, Pitman, Melissa R, Wilson, Claire H, Park, Joohong, Menz, R Ian, Starr, Amanda E, Cox, Jennifer H, Abbott, Catherine A, Overall, Christopher M, Gorrell, Mark D

“…N-terminal truncation of chemokines by proteases including dipeptidyl peptidase (DP) IV significantly alters their biological activity; generally ablating…”
Get full text