Search Results - "Wilson, Cara C"

Inside Out: HIV, the Gut Microbiome, and the Mucosal Immune System by Liu, Jay, Williams, Brett, Frank, Daniel, Dillon, Stephanie M, Wilson, Cara C, Landay, Alan L

“…The components of the human gut microbiome have been found to influence a broad array of pathologic conditions ranging from heart disease to diabetes and even…”
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Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms by Harper, Michael S, Guo, Kejun, Gibbert, Kathrin, Lee, Eric J, Dillon, Stephanie M, Barrett, Bradley S, McCarter, Martin D, Hasenkrug, Kim J, Dittmer, Ulf, Wilson, Cara C, Santiago, Mario L

“…HIV-1 is transmitted primarily across mucosal surfaces and rapidly spreads within the intestinal mucosa during acute infection. The type I interferons (IFNs)…”
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Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFNγ Production From Human Colonic ILC3s via Multiple Mechanisms by Castleman, Moriah J, Dillon, Stephanie M, Purba, Christine M, Cogswell, Andrew C, Kibbie, Jon J, McCarter, Martin D, Santiago, Mario L, Barker, Edward, Wilson, Cara C

“…Innate lymphoid cells (ILCs) are a diverse family of cells that play critical roles in mucosal immunity. One subset of the ILC family, Group 3 ILCs (ILC3s),…”
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Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 Pathogenesis by Guo, Kejun, Shen, Guannan, Kibbie, Jon, Gonzalez, Tania, Dillon, Stephanie M, Smith, Harry A, Cooper, Emily H, Lavender, Kerry, Hasenkrug, Kim J, Sutter, Kathrin, Dittmer, Ulf, Kroehl, Miranda, Kechris, Katerina, Wilson, Cara C, Santiago, Mario L

“…The Type I Interferons (IFN-Is) are innate antiviral cytokines that include 12 different IFNα subtypes and IFNβ that signal through the IFN-I receptor (IFNAR),…”
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Efficacy of a nucleoside-sparing regimen of darunavir/ ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262) by TAIWO, Babafemi, LU ZHENG, ERON, Joseph J, GALLIEN, Sebastien, MATINING, Roy M, KURITZKES, Daniel R, WILSON, Cara C, BERZINS, Baiba I, ACOSTA, Edward P, BASTOW, Barbara, KIM, Peter S

“…To explore darunavir/ritonavir (DRV/r) plus raltegravir (RAL) combination therapy in antiretroviral-naive patients. Phase IIb, single-arm, open-label,…”
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Contribution of intestinal barrier damage, microbial translocation and HIV-1 infection status to an inflammaging signature by Steele, Amanda K, Lee, Eric J, Vestal, Brian, Hecht, Daniel, Dong, Zachary, Rapaport, Eric, Koeppe, John, Campbell, Thomas B, Wilson, Cara C

“…Systemic inflammation is a characteristic of both HIV-1 infection and aging ("inflammaging"). Intestinal epithelial barrier damage (IEBD) and microbial…”
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The transcriptome of HIV-1 infected intestinal CD4+ T cells exposed to enteric bacteria by Yoder, Alyson C, Guo, Kejun, Dillon, Stephanie M, Phang, Tzu, Lee, Eric J, Harper, Michael S, Helm, Karen, Kappes, John C, Ochsenbauer, Christina, McCarter, Martin D, Wilson, Cara C, Santiago, Mario L

“…Global transcriptome studies can help pinpoint key cellular pathways exploited by viruses to replicate and cause pathogenesis. Previous data showed that…”
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Pathogenesis of Aging and Age-related Comorbidities in People with HIV: Highlights from the HIV ACTION Workshop by Gabuzda, Dana, Jamieson, Beth D, Collman, Ronald G, Lederman, Michael M, Burdo, Tricia H, Deeks, Steven G, Dittmer, Dirk P, Fox, Howard S, Funderburg, Nicholas T, Pahwa, Savita G, Pandrea, Ivona, Wilson, Cara C, Hunt, Peter W

“…People with HIV (PWH) experience accentuated biological aging, as defined by markers of inflammation, immune dysfunction, and the epigenetic clock. They also…”
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Granzyme B+ CD4 T cells accumulate in the colon during chronic HIV-1 infection by Dillon, Stephanie M., Mickens, Kaylee L., Thompson, Tezha A., Cooper, Emily H., Nesladek, Sabrina, Christians, Allison J., Castleman, Moriah, Guo, Kejun, Wood, Cheyret, Frank, Daniel N., Kechris, Katerina, Santiago, Mario L., Wilson, Cara C.

“…Chronic HIV-1 infection results in the sustained disruption of gut homeostasis culminating in alterations in microbial communities (dysbiosis) and increased…”
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Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults by Dillon, Stephanie M, Thompson, Tezha A, Christians, Allison J, McCarter, Martin D, Wilson, Cara C

“…The etiology of the low-level chronic inflammatory state associated with aging is likely multifactorial, but a number of animal and human studies have…”
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An exercise intervention alters stool microbiota and metabolites among older, sedentary adults by Erlandson, Kristine M., Liu, Jay, Johnson, Rachel, Dillon, Stephanie, Jankowski, Catherine M., Kroehl, Miranda, Robertson, Charles E., Frank, Daniel N., Tuncil, Yunus, Higgins, Janine, Hamaker, Bruce, Wilson, Cara C.

“…Background: Physiologic aging has been associated with gut dysbiosis. Although short exercise interventions have been linked to beneficial changes in gut…”
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Human intestinal lamina propria CD1c+ dendritic cells display an activated phenotype at steady state and produce IL-23 in response to TLR7/8 stimulation by Dillon, Stephanie M, Rogers, Lisa M, Howe, Rawleigh, Hostetler, Lydia A, Buhrman, Jonathan, McCarter, Martin D, Wilson, Cara C

“…Intestinal dendritic cells (DCs) play key roles in mediating tolerance to commensal flora and inflammatory responses against mucosal pathogens. The mechanisms…”
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The gut microbiome and HIV-1 pathogenesis: a two-way street by Dillon, Stephanie M, Frank, Daniel N, Wilson, Cara C

“…HIV-1 infection is associated with substantial damage to the gastrointestinal tract resulting in structural impairment of the epithelial barrier and a…”
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Influence of Plasma Viremia on Defects in Number and Immunophenotype of Blood Dendritic Cell Subsets in Human Immunodeficiency Virus 1–Infected Individuals by Barron, Michelle A., Blyveis, Naomi, Palmer, Brent E., MaWhinney, Samantha, Wilson, Cara C.

“…Dendritic cells (DCs) are postulated to be involved in transmission of human immunodeficiency virus (HIV) type 1 to T cells and in stimulation of…”
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Increased Escherichia coli-Induced Interleukin-23 Production by CD16+ Monocytes Correlates with Systemic Immune Activation in Untreated HIV-1-Infected Individuals by Manuzak, Jennifer A, Dillon, Stephanie M, Lee, Eric J, Dong, Zachary M, Hecht, Daniel K, Wilson, Cara C

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Blood Myeloid Dendritic Cells from HIV-1-Infected Individuals Display a Proapoptotic Profile Characterized by Decreased Bcl-2 Levels and by Caspase-3+ Frequencies That Are Associated with Levels of Plasma Viremia and T Cell Activation in an Exploratory Study by DILLON, Stephanie M, FRIEDLANDER, Laura J, ROGERS, Lisa M, MEDITZ, Amie L, FOLKVORD, Joy M, CONNICK, Elizabeth, MCCARTER, Martin D, WILSON, Cara C

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Soluble Markers of Inflammation and Coagulation but Not T-Cell Activation Predict Non-AIDS-Defining Morbid Events During Suppressive Antiretroviral Treatment by Tenorio, Allan R., Zheng, Yu, Bosch, Ronald J., Krishnan, Supriya, Rodriguez, Benigno, Hunt, Peter W., Plants, Jill, Seth, Arjun, Wilson, Cara C., Deeks, Steven G., Lederman, Michael M., Landay, Alan L.

“…Background. Defining the association of non-AIDS-defining events with inflammation and immune activation among human immunodeficiency virus (HIV)-infected…”
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Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity by Duke, Richard C, Wilson, Cara C, Stubbs, Andrew C, Martin, Kathleen S, Coeshott, Claire, Skaates, Serena V, Kuritzkes, Daniel R, Bellgrau, Donald, Franzusoff, Alex

“…There is currently a need for vaccines that stimulate cell-mediated immunity-particularly that mediated by CD8+ cytotoxic T lymphocytes (CTLs)-against viral…”
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Four Weeks of Treatment With Rifaximin Fails to Significantly Alter Microbial Diversity in Rectal Samples of HIV-Infected Immune Non-Responders (ACTG A5286) Which May be Attributed to Rectal Swab Use by Williams, Brett B, Green, Stefan J, Bosch, Ronald J, Chan, Ellen S, Jacobson, Jeffrey M, Margolis, David M, Engen, Phillip, Landay, Alan L, Wilson, Cara C

“…HIV-infected individuals have evidence of intestinal microbial translocation which is associated with immune activation and unfavorable clinical outcomes…”
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Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation by Dillon, Stephanie M, Kibbie, Jon, Lee, Eric J, Guo, Kejun, Santiago, Mario L, Austin, Gregory L, Gianella, Sara, Landay, Alan L, Donovan, Andrew M, Frank, Daniel N, McCarter, Martin D, Wilson, Cara C

“…OBJECTIVE:Gut microbial translocation is a major driving force behind chronic immune activation during HIV-1 infection. HIV-1-related intestinal dysbiosis,…”
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