Search Results - "Wilson, Ashley L."

Cellular Therapy for Children with Central Nervous System Tumors: Mining and Mapping the Correlative Data by Crotty, Erin E., Wilson, Ashley L., Davidson, Tom, Tahiri, Sophia, Gust, Juliane, Griesinger, Andrea M., Venkataraman, Sujatha, Park, Julie R., Mueller, Sabine, Rood, Brian R., Hwang, Eugene I., Wang, Leo D., Vitanza, Nicholas A.

“…Purpose of Review Correlative studies should leverage clinical trial frameworks to conduct biospecimen analyses that provide insight into the bioactivity of…”
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Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells by Wilson, Ashley L, Schrecengost, Randy S, Guerrero, Michael S, Thomas, Keena S, Bouton, Amy H

“…Metastatic breast cancer is incurable. In order to improve patient survival, it is critical to develop a better understanding of the molecular mechanisms that…”
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Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis by Vitanza, Nicholas A., Johnson, Adam J., Wilson, Ashley L., Brown, Christopher, Yokoyama, Jason K., Künkele, Annette, Chang, Cindy A., Rawlings-Rhea, Stephanie, Huang, Wenjun, Seidel, Kristy, Albert, Catherine M., Pinto, Navin, Gust, Juliane, Finn, Laura S., Ojemann, Jeffrey G., Wright, Jason, Orentas, Rimas J., Baldwin, Michael, Gardner, Rebecca A., Jensen, Michael C., Park, Julie R.

“…Locoregional delivery of chimeric antigen receptor (CAR) T cells has resulted in objective responses in adults with glioblastoma, but the feasibility and…”
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Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety by Vitanza, Nicholas A, Wilson, Ashley L, Huang, Wenjun, Seidel, Kristy, Brown, Christopher, Gustafson, Joshua A, Yokoyama, Jason K, Johnson, Adam J, Baxter, Blake A, Koning, Ryan W, Reid, Aquene N, Meechan, Michael, Biery, Matthew C, Myers, Carrie, Rawlings-Rhea, Stephanie D, Albert, Catherine M, Browd, Samuel R, Hauptman, Jason S, Lee, Amy, Ojemann, Jeffrey G, Berens, Michael E, Dun, Matthew D, Foster, Jessica B, Crotty, Erin E, Leary, Sarah E S, Cole, Bonnie L, Perez, Francisco A, Wright, Jason N, Orentas, Rimas J, Chour, Tony, Newell, Evan W, Whiteaker, Jeffrey R, Zhao, Lei, Paulovich, Amanda G, Pinto, Navin, Gust, Juliane, Gardner, Rebecca A, Jensen, Michael C, Park, Julie R

“…Diffuse intrinsic pontine glioma (DIPG) remains a fatal brainstem tumor demanding innovative therapies. As B7-H3 (CD276) is expressed on central nervous system…”
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Alignment of practices for data harmonization across multi-center cell therapy trials: a report from the Consortium for Pediatric Cellular Immunotherapy by Abdel-Azim, Hisham, Dave, Hema, Jordan, Kimberly, Rawlings-Rhea, Stephanie, Luong, Annie, Wilson, Ashley L.

“…Immune effector cell (IEC) therapies have revolutionized our approach to relapsed B-cell malignancies, and interest in the investigational use of IECs is…”
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STRIvE-02: A First-in-Human Phase I Study of Systemically Administered B7-H3 Chimeric Antigen Receptor T Cells for Patients With Relapsed/Refractory Solid Tumors by Pinto, Navin, Albert, Catherine M, Taylor, Mallory R, Ullom, Heidi B, Wilson, Ashley L, Huang, Wenjun, Wendler, Jason, Pattabhi, Sowmya, Seidel, Kristy, Brown, Christopher, Gustafson, Joshua A, Rawlings-Rhea, Stephanie D, Cheeney, Safia H E, Burleigh, Katelyn, Gustafson, Heather H, Orentas, Rimas J, Vitanza, Nicholas A, Gardner, Rebecca A, Jensen, Michael C, Park, Julie R

“…B7-H3 is an immunoregulatory protein overexpressed by many pediatric solid tumors with limited expression on critical organs, making it an attractive…”
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Differential protein-protein interactions underlie signaling mediated by the TCR and a 4-1BB domain-containing CAR by Ritmeester-Loy, Samuel A, Draper, Isabella H, Bueter, Eric C, Lautz, Jonathan D, Zhang-Wong, Yue, Gustafson, Joshua A, Wilson, Ashley L, Lin, Chenwei, Gafken, Philip R, Jensen, Michael C, Orentas, Rimas, Smith, Stephen E P

“…Cells rely on activity-dependent protein-protein interactions to convey biological signals. For chimeric antigen receptor (CAR) T cells containing a 4-1BB…”
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Pathogenetics of alveolar capillary dysplasia with misalignment of pulmonary veins by Szafranski, Przemyslaw, Gambin, Tomasz, Dharmadhikari, Avinash V., Akdemir, Kadir Caner, Jhangiani, Shalini N., Schuette, Jennifer, Godiwala, Nihal, Yatsenko, Svetlana A., Sebastian, Jessica, Madan-Khetarpal, Suneeta, Surti, Urvashi, Abellar, Rosanna G., Bateman, David A., Wilson, Ashley L., Markham, Melinda H., Slamon, Jill, Santos-Simarro, Fernando, Palomares, María, Nevado, Julián, Lapunzina, Pablo, Chung, Brian Hon-Yin, Wong, Wai-Lap, Chu, Yoyo Wing Yiu, Mok, Gary Tsz Kin, Kerem, Eitan, Reiter, Joel, Ambalavanan, Namasivayam, Anderson, Scott A., Kelly, David R., Shieh, Joseph, Rosenthal, Taryn C., Scheible, Kristin, Steiner, Laurie, Iqbal, M. Anwar, McKinnon, Margaret L., Hamilton, Sara Jane, Schlade-Bartusiak, Kamilla, English, Dawn, Hendson, Glenda, Roeder, Elizabeth R., DeNapoli, Thomas S., Littlejohn, Rebecca Okashah, Wolff, Daynna J., Wagner, Carol L., Yeung, Alison, Francis, David, Fiorino, Elizabeth K., Edelman, Morris, Fox, Joyce, Hayes, Denise A., Janssens, Sandra, De Baere, Elfride, Menten, Björn, Loccufier, Anne, Vanwalleghem, Lieve, Moerman, Philippe, Sznajer, Yves, Lay, Amy S., Kussmann, Jennifer L., Chawla, Jasneek, Payton, Diane J., Phillips, Gael E., Brosens, Erwin, Tibboel, Dick, de Klein, Annelies, Maystadt, Isabelle, Fisher, Richard, Sebire, Neil, Male, Alison, Chopra, Maya, Pinner, Jason, Malcolm, Girvan, Peters, Gregory, Arbuckle, Susan, Lees, Melissa, Mead, Zoe, Quarrell, Oliver, Sayers, Richard, Owens, Martina, Shaw-Smith, Charles, Lioy, Janet, McKay, Eileen, de Leeuw, Nicole, Feenstra, Ilse, Spruijt, Liesbeth, Elmslie, Frances, Thiruchelvam, Timothy, Bacino, Carlos A., Langston, Claire, Lupski, James R., Sen, Partha, Popek, Edwina, Stankiewicz, Paweł

“…Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by heterozygous point mutations or…”
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Availability of Services and Caregiver Burden: Supporting Individuals With Neurogenetic Conditions During the COVID-19 Pandemic by Kowanda, Michelle, Cartner, Lindsey, Kentros, Catherine, Geltzeiler, Alexa R., Singer, Kaitlyn E., Weaver, W. Curtis, Lehman, Christopher D., Smith, Simone, Smith, Rebecca Sheedy, Walsh, Lauren Kasparson, Diehl, Katharine, Nagpal, Natalie, Brooks, Elizabeth, Mebane, Caroline M., Wilson, Ashley L., Marvin, Alison R., White, L. Casey, Law, J. Kiely, Jensen, William, Daniels, Amy M., Tjernagel, Jennifer, Snyder, LeeAnne Green, Taylor, Cora M., Chung, Wendy K.

“…Because of the COVID-19 pandemic, in-person services for individuals with neurodevelopmental disabilities were disrupted globally, resulting in a transition to…”
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“I was very scared when I found out my son had sickle cell”: Caregiver knowledge and attitudes toward early intervention for young children with sickle cell disease: Implications for policy and practice from a multi‐site study by Hoyt, Catherine R., MacArthur, Erin, Leaver, Hayes, Wilson, Ashley L., Davis, Kandace, Harris, Kelly M., Damiano, Riley, Moore, Hunter, Housten, Ashley J., Britts, Rosemary, Hankins, Jane Silva, King, Allison A., Heitzer, Andrew M.

“…Objective This study characterized caregivers’ beliefs related to early intervention services for children with sickle cell disease (SCD) to gain an indepth…”
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Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety by Vitanza, Nicholas A., Ronsley, Rebecca, Choe, Michelle, Henson, Casey, Breedt, Mandy, Barrios-Anderson, Adriel, Wein, Amy, Brown, Christopher, Beebe, Adam, Kong, Ada, Kirkey, Danielle, Lee, Brittany M., Leary, Sarah E.S., Crotty, Erin E., Hoeppner, Corrine, Holtzclaw, Susan, Wilson, Ashley L., Gustafson, Joshua A., Foster, Jessica B., Iliff, Jeffrey J., Goldstein, Hannah E., Browd, Samuel R., Lee, Amy, Ojemann, Jeffrey G., Pinto, Navin, Gust, Juliane, Gardner, Rebecca A., Jensen, Michael C., Hauptman, Jason S., Park, Julie R.

“…Central nervous system (CNS) tumors are the most common solid malignancy in the pediatric population. Based on adoptive cellular therapy's clinical success…”
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Cell‐Templated Silica Microparticles with Supported Lipid Bilayers as Artificial Antigen‐Presenting Cells for T Cell Activation by Olden, Brynn R., Perez, Caleb R., Wilson, Ashley L., Cardle, Ian I., Lin, Yu‐Shen, Kaehr, Bryan, Gustafson, Joshua A., Jensen, Michael C., Pun, Suzie H.

“…Biomaterial properties that modulate T cell activation, growth, and differentiation are of significant interest in the field of cellular immunotherapy…”
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NanoString Digital Molecular Profiling of Protein and microRNA in Rhabdomyosarcoma by Ahmed, Atif A, Farooqi, Midhat S, Habeebu, Sultan S, Gonzalez, Elizabeth, Flatt, Terrie G, Wilson, Ashley L, Barr, Frederic G

“…Rhabdomyosarcoma (RMS) exhibits a complex prognostic algorithm based on histologic, biologic and clinical parameters. The embryonal (ERMS) and spindle…”
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Impact of patient education videos on genetic counseling outcomes after exome sequencing by Hernan, Rebecca, Cho, Megan T., Wilson, Ashley L., Ahimaz, Priyanka, Au, Catherine, Berger, Sara M., Guzman, Edwin, Primiano, Michelle, Shaw, Jessica E., Ross, Meredith, Tabanfar, Leyla, Chilton, Ilana, Griffin, Emily, Ratner, Chana, Anyane-Yeboa, Kwame, Iglesias, Alejandro, Pisani, Laura, Roohi, Jasmin, Duong, Jimmy, Martinez, Josue, Appelbaum, Paul, Klitzman, Robert, Ottman, Ruth, Chung, Wendy K., Wynn, Julia

“…•Parents reported that educational videos were helpful in understanding genetics.•Satisfaction with genetic counseling was equivalent for standard care and…”
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Modified Manufacturing Process Modulates CD19CAR T-cell Engraftment Fitness and Leukemia-Free Survival in Pediatric and Young Adult Subjects by Ceppi, Francesco, Wilson, Ashley L, Annesley, Colleen, Kimmerly, Gabriella R, Summers, Corinne, Brand, Adam, Seidel, Kristy, Wu, Qian Vicky, Beebe, Adam, Brown, Christopher, Mgebroff, Stephanie, Lindgren, Catherine, Rawlings-Rhea, Stephanie D, Huang, Wenjun, Pulsipher, Michael A, Wayne, Alan S, Park, Julie R, Jensen, Michael C, Gardner, Rebecca A

“…T cells modified to express a chimeric antigen receptor (CAR) targeting CD19 can induce potent and sustained responses in children with relapsed/refractory…”
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Loss‐of‐function variants in NFIA provide further support that NFIA is a critical gene in 1p32‐p31 deletion syndrome: A four patient series by Revah‐Politi, Anya, Ganapathi, Mythily, Bier, Louise, Cho, Megan T., Goldstein, David B., Hemati, Parisa, Iglesias, Alejandro, Juusola, Jane, Pappas, John, Petrovski, Slavé, Wilson, Ashley L., Aggarwal, Vimla S., Anyane‐Yeboa, Kwame

“…The association between 1p32‐p31 contiguous gene deletions and a distinct phenotype that includes anomalies of the corpus callosum, ventriculomegaly,…”
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GFAP and NfL increase during neurotoxicity from high baseline levels in pediatric CD19-CAR T-cell patients by Gust, Juliane, Rawlings-Rhea, Stephanie D., Wilson, Ashley L., Tulberg, Niklas M., Sherman, Amber L., Seidel, Kristy D., Wu, Qian “Vicky”, Park, Julie R., Gardner, Rebecca A., Annesley, Colleen E.

“…•cGFAP and cNfL levels increase in pediatric patients during CAR T-cell–associated neurotoxicity, indicating injury to astrocytes and neurons.•Nervous system…”
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Differential Expression of Homing Receptor Ligands on Tumor-Associated Vasculature that Control CD8 Effector T-cell Entry by Woods, Amber N, Wilson, Ashley L, Srivinisan, Nithya, Zeng, Jianhao, Dutta, Arun B, Peske, J David, Tewalt, Eric F, Gregg, Randal K, Ferguson, Andrew R, Engelhard, Victor H

“…Although CD8 T cells are critical for controlling tumors, how they are recruited and home to primary and metastatic lesions is incompletely understood. We…”
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A stem cell epigenome is associated with primary nonresponse to CD19 CAR T cells in pediatric acute lymphoblastic leukemia by Masih, Katherine E., Gardner, Rebecca A., Chou, Hsien-Chao, Abdelmaksoud, Abdalla, Song, Young K., Mariani, Luca, Gangalapudi, Vineela, Gryder, Berkley E., Wilson, Ashley L., Adebola, Serifat O., Stanton, Benjamin Z., Wang, Chaoyu, Milewski, David, Kim, Yong Yean, Tian, Meijie, Cheuk, Adam Tai-Chi, Wen, Xinyu, Zhang, Yue, Altan-Bonnet, Grégoire, Kelly, Michael C., Wei, Jun S., Bulyk, Martha L., Jensen, Michael C., Orentas, Rimas J., Khan, Javed

“…•Multiomic investigation of pretreatment bone marrow identifies a primary nonresponder signature to CD19-CAR in childhood B-ALL.•Primary nonresponders harbor…”
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De novo mutations in PURA are associated with hypotonia and developmental delay by Tanaka, Akemi J, Bai, Renkui, Cho, Megan T, Anyane-Yeboa, Kwame, Ahimaz, Priyanka, Wilson, Ashley L, Kendall, Fran, Hay, Beverly, Moss, Timothy, Nardini, Monica, Bauer, Mislen, Retterer, Kyle, Juusola, Jane, Chung, Wendy K

“…PURA is the leading candidate gene responsible for the developmental phenotype in the 5q31.3 microdeletion syndrome. De novo mutations in PURA were recently…”
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