Search Results - "Wilsch, Michaela"
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Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
Published in Proceedings of the National Academy of Sciences - PNAS (22-12-2015)“…Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem cells—have emerged as models of human cortical development. However, the…”
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Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex
Published in The EMBO journal (01-10-2021)“…The role of WNT/β‐catenin signalling in mouse neocortex development remains ambiguous. Most studies demonstrate that WNT/β‐catenin regulates progenitor…”
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How neural stem cells contribute to neocortex development
Published in Biochemical Society transactions (01-11-2021)“…The mammalian neocortex is the seat of higher cognitive functions, such as thinking and language in human. A hallmark of the neocortex are the cortical…”
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Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis
Published in Neuron (Cambridge, Mass.) (04-03-2020)“…The human-specific gene ARHGAP11B is preferentially expressed in neural progenitors of fetal human neocortex and increases abundance and proliferation of basal…”
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Neocortex expansion in development and evolution — from cell biology to single genes
Published in Current opinion in neurobiology (01-08-2016)“…Highlights • Cell biology of apical cell polarity loss and newborn basal progenitor delamination. • Cell biological basis of sustaining basal progenitor…”
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OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Published in Nature neuroscience (01-06-2010)“…This work identifies a population of precursors in the outer subventricular zone (SVZ) of developing human and ferret brains. The cells share some properties…”
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Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division
Published in Cell (10-10-2013)“…Primary cilia are key sensory organelles that are thought to be disassembled prior to mitosis. Inheritance of the mother centriole, which nucleates the primary…”
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Primary Cilia and Centrosomes in Neocortex Development
Published in Frontiers in neuroscience (21-10-2021)“…During mammalian brain development, neural stem and progenitor cells generate the neurons for the six-layered neocortex. The proliferative capacity of the…”
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Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
Published in Developmental cell (23-01-2023)“…WNT signaling is important in development, stem cell maintenance, and disease. WNT ligands typically signal via receptor activation across the plasma membrane…”
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Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7
Published in Neuron (Cambridge, Mass.) (21-03-2018)“…Delamination of neural progenitor cells (NPCs) from the ventricular surface is a crucial prerequisite to form the subventricular zone, the germinal layer…”
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Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation
Published in Science (American Association for the Advancement of Science) (05-02-2010)“…Microtubules are polymeric protein structures and components of the cytoskeleton. Their dynamic polymerization is important for diverse cellular functions. The…”
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Prominin‐1 (CD133) modulates the architecture and dynamics of microvilli
Published in Traffic (Copenhagen, Denmark) (01-01-2019)“…Prominin‐1 is a cell surface biomarker that allows the identification of stem and cancer stem cells from different organs. It is also expressed in several…”
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Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells
Published in Journal of cell science (01-07-2005)“…Apical plasma membrane constituents of mammalian neural stem/progenitor cells have recently been implicated in maintaining their stem/progenitor cell state…”
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Cell Free Expression in Proteinosomes Prepared from Native Protein‐PNIPAAm Conjugates
Published in Macromolecular bioscience (01-03-2024)“…Towards the goal of building synthetic cells from the bottom‐up, the establishment of micrometer‐sized compartments that contain and support cell free…”
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Myosin II Is Required for Interkinetic Nuclear Migration of Neural Progenitors
Published in Proceedings of the National Academy of Sciences - PNAS (22-09-2009)“…Interkinetic nuclear migration (INM) is a hallmark of the polarized stem and progenitor cells in the ventricular zone (VZ) of the developing vertebrate CNS…”
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insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
Published in Nature (15-01-2009)“…The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal…”
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3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells
Published in Stem cell reports (09-12-2014)“…Inducing organogenesis in 3D culture is an important aspect of stem cell research. Anterior neural structures have been produced from large embryonic stem cell…”
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Bile canaliculi remodeling activates YAP via the actin cytoskeleton during liver regeneration
Published in Molecular systems biology (01-02-2020)“…The mechanisms of organ size control remain poorly understood. A key question is how cells collectively sense the overall status of a tissue. We addressed this…”
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Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1
Published in The Journal of cell biology (12-02-2007)“…Expansion of the neocortex requires symmetric divisions of neuroepithelial cells, the primary progenitor cells of the developing mammalian central nervous…”
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Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells
Published in Scientific reports (16-02-2016)“…Apical radial glia (aRG), the stem cells in developing neocortex, are unique bipolar epithelial cells, extending an apical process to the ventricle and a basal…”
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