Search Results - "Wilming, Laurens G"

Sequencing and characterization of the FVB/NJ mouse genome by Wong, Kim, Bumpstead, Suzannah, Van Der Weyden, Louise, Reinholdt, Laura G, Wilming, Laurens G, Adams, David J, Keane, Thomas M

“…BACKGROUND: The FVB/NJ mouse strain has its origins in a colony of outbred Swiss mice established in 1935 at the National Institutes of Health. Mice derived…”
Get full text

Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice by Mudge, Jonathan M, Armstrong, Stuart D, McLaren, Karen, Beynon, Robert J, Hurst, Jane L, Nicholson, Christine, Robertson, Duncan H, Wilming, Laurens G, Harrow, Jennifer L

“…The major urinary proteins (MUPs) of Mus musculus domesticus are deposited in urine in large quantities, where they bind and release pheromones and also…”
Get full text

Complete MHC haplotype sequencing for common disease gene mapping by Stewart, C Andrew, Horton, Roger, Allcock, Richard J N, Ashurst, Jennifer L, Atrazhev, Alexey M, Coggill, Penny, Dunham, Ian, Forbes, Simon, Halls, Karen, Howson, Joanna M M, Humphray, Sean J, Hunt, Sarah, Mungall, Andrew J, Osoegawa, Kazutoyo, Palmer, Sophie, Roberts, Anne N, Rogers, Jane, Sims, Sarah, Wang, Yu, Wilming, Laurens G, Elliott, John F, de Jong, Pieter J, Sawcer, Stephen, Todd, John A, Trowsdale, John, Beck, Stephan

“…The future systematic mapping of variants that confer susceptibility to common diseases requires the construction of a fully informative polymorphism map…”
Get full text

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history by Traherne, James A, Horton, Roger, Roberts, Anne N, Miretti, Marcos M, Hurles, Matthew E, Stewart, C Andrew, Ashurst, Jennifer L, Atrazhev, Alexey M, Coggill, Penny, Palmer, Sophie, Almeida, Jeff, Sims, Sarah, Wilming, Laurens G, Rogers, Jane, de Jong, Pieter J, Carrington, Mary, Elliott, John F, Sawcer, Stephen, Todd, John A, Trowsdale, John, Beck, Stephan

“…The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in…”
Get full text

Identification of putative noncoding RNAs among the RIKEN mouse full-length cDNA collection by Numata, Koji, Kanai, Akio, Saito, Rintaro, Kondo, Shinji, Adachi, Jun, Wilming, Laurens G, Hume, David A, Hayashizaki, Yoshihide, Tomita, Masaru

“…With the sequencing and annotation of genomes and transcriptomes of several eukaryotes, the importance of noncoding RNA (ncRNA)-RNA molecules that are not…”
Get full text

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin by Boles, Melissa K, Wilkinson, Bonney M, Wilming, Laurens G, Liu, Bin, Probst, Frank J, Harrow, Jennifer, Grafham, Darren, Hentges, Kathryn E, Woodward, Lanette P, Maxwell, Andrea, Mitchell, Karen, Risley, Michael D, Johnson, Randy, Hirschi, Karen, Lupski, James R, Funato, Yosuke, Miki, Hiroaki, Marin-Garcia, Pablo, Matthews, Lucy, Coffey, Alison J, Parker, Anne, Hubbard, Tim J, Rogers, Jane, Bradley, Allan, Adams, David J, Justice, Monica J

“…An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete DNA sequence and gene…”
Get full text

Pseudo-messenger RNA: phantoms of the transcriptome by Frith, Martin C, Wilming, Laurens G, Forrest, Alistair, Kawaji, Hideya, Tan, Sin Lam, Wahlestedt, Claes, Bajic, Vladimir B, Kai, Chikatoshi, Kawai, Jun, Carninci, Piero, Hayashizaki, Yoshihide, Bailey, Timothy L, Huminiecki, Lukasz

“…The mammalian transcriptome harbours shadowy entities that resist classification and analysis. In analogy with pseudogenes, we define pseudo-messenger RNA to…”
Get full text

Current status and new features of the Consensus Coding Sequence database by Farrell, Catherine M, O'Leary, Nuala A, Harte, Rachel A, Loveland, Jane E, Wilming, Laurens G, Wallin, Craig, Diekhans, Mark, Barrell, Daniel, Searle, Stephen M J, Aken, Bronwen, Hiatt, Susan M, Frankish, Adam, Suner, Marie-Marthe, Rajput, Bhanu, Steward, Charles A, Brown, Garth R, Bennett, Ruth, Murphy, Michael, Wu, Wendy, Kay, Mike P, Hart, Jennifer, Rajan, Jeena, Weber, Janet, Snow, Catherine, Riddick, Lillian D, Hunt, Toby, Webb, David, Thomas, Mark, Tamez, Pamela, Rangwala, Sanjida H, McGarvey, Kelly M, Pujar, Shashikant, Shkeda, Andrei, Mudge, Jonathan M, Gonzalez, Jose M, Gilbert, James G R, Trevanion, Stephen J, Baertsch, Robert, Harrow, Jennifer L, Hubbard, Tim, Ostell, James M, Haussler, David, Pruitt, Kim D

“…The Consensus Coding Sequence (CCDS) project (http://www.ncbi.nlm.nih.gov/CCDS/) is a collaborative effort to maintain a dataset of protein-coding regions that…”
Get full text

The Vertebrate Genome Annotation browser 10 years on by Harrow, Jennifer L, Steward, Charles A, Frankish, Adam, Gilbert, James G, Gonzalez, Jose M, Loveland, Jane E, Mudge, Jonathan, Sheppard, Dan, Thomas, Mark, Trevanion, Stephen, Wilming, Laurens G

“…The Vertebrate Genome Annotation (VEGA) database (http://vega.sanger.ac.uk), initially designed as a community resource for browsing manual annotation of the…”
Get full text

Comprehensive comparative homeobox gene annotation in human and mouse by Wilming, Laurens G, Boychenko, Veronika, Harrow, Jennifer L

“…Homeobox genes are a group of genes coding for transcription factors with a DNA-binding helix-turn-helix structure called a homeodomain and which play a…”
Get full text

The tammar wallaby major histocompatibility complex shows evidence of past genomic instability by Siddle, Hannah V, Deakin, Janine E, Coggill, Penny, Whilming, Laurens G, Harrow, Jennifer, Kaufman, Jim, Beck, Stephan, Belov, Katherine

“…The major histocompatibility complex (MHC) is a group of genes with a variety of roles in the innate and adaptive immune responses. MHC genes form a…”
Get full text

Sequencing and comparative analysis of the gorilla MHC genomic sequence by Wilming, Laurens G, Hart, Elizabeth A, Coggill, Penny C, Horton, Roger, Gilbert, James G R, Clee, Chris, Jones, Matt, Lloyd, Christine, Palmer, Sophie, Sims, Sarah, Whitehead, Siobhan, Wiley, David, Beck, Stephan, Harrow, Jennifer L

“…Major histocompatibility complex (MHC) genes play a critical role in vertebrate immune response and because the MHC is linked to a significant number of…”
Get full text

Meeting report: a workshop on Best Practices in Genome Annotation by Madupu, Ramana, Brinkac, Lauren M, Harrow, Jennifer, Wilming, Laurens G, Böhme, Ulrike, Lamesch, Philippe, Hannick, Linda I

“…Efforts to annotate the genomes of a wide variety of model organisms are currently carried out by sequencing centers, model organism databases and…”
Get full text

A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the mullerian duct by BAARENDS, W. M, VAN HELMOND, M. J. L, THEMMEN, A. P. N, GROOTEGOED, J, POST, M, VAN DER SCHOOT, P. J. C. M, HOOGERBRUGGE, J. W, DE WINTER, J. P, UILENBROEK, J. T. J, KARELS, B, WILMING, L. G, MEIJERS, J. H. C

“…The activin and TGF-beta type II receptors are members of a separate subfamily of transmembrane receptors with intrinsic protein kinase activity, which also…”
Get full text

Expression of cell growth and bone specific genes at single cell resolution during development of bone tissue-like organization in primary osteoblast cultures by Pockwinse, S M, Wilming, L G, Conlon, D M, Stein, G S, Lian, J B

“…Primary cultures of calvarial derived normal diploid osteoblasts undergo a developmental expression of genes reflecting growth, extracellular matrix…”
Get more information

Updates to the Alliance of Genome Resources central infrastructure by Aleksander, Suzanne A, Anagnostopoulos, Anna V, Antonazzo, Giulia, Arnaboldi, Valerio, Attrill, Helen, Becerra, Andrés, Bello, Susan M, Blodgett, Olin, Bradford, Yvonne M, Bult, Carol J, Cain, Scott, Calvi, Brian R, Carbon, Seth, Chan, Juancarlos, Chen, Wen J, Cherry, J Michael, Cho, Jaehyoung, Crosby, Madeline A, De Pons, Jeffrey L, D’Eustachio, Peter, Diamantakis, Stavros, Dolan, Mary E, dos Santos, Gilberto, Dyer, Sarah, Ebert, Dustin, Engel, Stacia R, Fashena, David, Fisher, Malcolm, Foley, Saoirse, Gibson, Adam C, Gollapally, Varun R, Gramates, L Sian, Grove, Christian A, Hale, Paul, Harris, Todd, Hayman, G Thomas, Hu, Yanhui, James-Zorn, Christina, Karimi, Kamran, Karra, Kalpana, Kishore, Ranjana, Kwitek, Anne E, Laulederkind, Stanley J F, Lee, Raymond, Longden, Ian, Luypaert, Manuel, Markarian, Nicholas, Marygold, Steven J, Matthews, Beverley, McAndrews, Monica S, Millburn, Gillian, Miyasato, Stuart, Motenko, Howie, Moxon, Sierra, Muller, Hans-Michael, Mungall, Christopher J, Muruganujan, Anushya, Mushayahama, Tremayne, Nash, Robert S, Nuin, Paulo, Paddock, Holly, Pells, Troy, Perrimon, Norbert, Pich, Christian, Quinton-Tulloch, Mark, Raciti, Daniela, Ramachandran, Sridhar, Richardson, Joel E, Gelbart, Susan Russo, Ruzicka, Leyla, Schindelman, Gary, Shaw, David R, Sherlock, Gavin, Shrivatsav, Ajay, Singer, Amy, Smith, Constance M, Smith, Cynthia L, Smith, Jennifer R, Stein, Lincoln, Sternberg, Paul W, Tabone, Christopher J, Thomas, Paul D, Thorat, Ketaki, Thota, Jyothi, Tomczuk, Monika, Trovisco, Vitor, Tutaj, Marek A, Urbano, Jose-Maria, Van Auken, Kimberly, Van Slyke, Ceri E, Vize, Peter D, Wang, Qinghua, Weng, Shuai, Westerfield, Monte, Wilming, Laurens G, Wong, Edith D, Wright, Adam, Yook, Karen, Zhou, Pinglei, Zorn, Aaron

“…The Alliance of Genome Resources (Alliance) is an extensible coalition of knowledgebases focused on the genetics and genomics of intensively studied model…”
Get full text

Harmonizing model organism data in the Alliance of Genome Resources by Agapite, Julie, Albou, Laurent-Philippe, Aleksander, Suzanne A., Anagnostopoulos, Anna V., Antonazzo, Giulia, Argasinska, Joanna, Attrill, Helen, Becerra, Andrés, Bello, Susan M., Blake, Judith A., Blodgett, Olin, Bradford, Yvonne M., Bult, Carol J., Cain, Scott, Calvi, Brian R., Carbon, Seth, Chen, Wen J., Cho, Jaehyoung, Christie, Karen R., Crosby, Madeline A., Davis, Paul, da Veiga Beltrame, Eduardo, D’Eustachio, Peter, Diamantakis, Stavros, Dolan, Mary E., Douglass, Eric, Dunn, Barbara, Eagle, Anne, Engel, Stacia R., Foley, Saoirse, Frazer, Ken, Gao, Sibyl, Gondwe, Felix, Goodman, Josh, Sian Gramates, L., Grove, Christian A., Hale, Paul, Harris, Todd, Thomas Hayman, G., Hill, David P., Howe, Douglas G., Howe, Kevin L., Hu, Yanhui, Kaufman, Thomas C., Karra, Kalpana, Kishore, Ranjana, Kwitek, Anne E., Lee, Raymond, Longden, Ian, Luypaert, Manuel, MacPherson, Kevin A., Martin, Ryan, Marygold, Steven J., Matthews, Beverley, McAndrews, Monica S., Miyasato, Stuart, Motenko, Howie, Muller, Hans-Michael, Mungall, Christopher J., Muruganujan, Anushya, Mushayahama, Tremayne, Nalabolu, Harika S., Nash, Robert S., Ng, Patrick, Paulini, Michael, Perrimon, Norbert, Raciti, Daniela, Ramachandran, Sridhar, Richardson, Joel E., Gelbart, Susan Russo, Ruzicka, Leyla, Schaper, Kevin, Schindelman, Gary, Shimoyama, Mary, Shrivatsav, Ajay, Singer, Amy, Skrzypek, Marek, Smith, Constance M., Smith, Cynthia L., Smith, Jennifer R., Stein, Lincoln, Sternberg, Paul W., Tabone, Christopher J., Thota, Jyothi, Tomczuk, Monika, Tutaj, Marek A., Urbano, Jose-Maria, Van Auken, Kimberly, Van Slyke, Ceri E., Wang, Qinghua, Wang, Shur-Jen, Weng, Shuai, Westerfield, Monte, Williams, Gary, Wilming, Laurens G., Wong, Edith D., Yook, Karen, Zarowiecki, Magdalena, Zhou, Pinglei, Zytkovicz, Mark

“…Abstract The Alliance of Genome Resources (the Alliance) is a combined effort of 7 knowledgebase projects: Saccharomyces Genome Database, WormBase, FlyBase,…”
Get full text

Discovery of Candidate Disease Genes in ENU-Induced Mouse Mutants by Large-Scale Sequencing, Including a Splice-Site Mutation in Nucleoredoxin: e1000759 by Boles, Melissa K, Wilkinson, Bonney M, Wilming, Laurens G, Liu, Bin, Probst, Frank J, Harrow, Jennifer, Grafham, Darren, Hentges, Kathryn E, Woodward, Lanette P, Maxwell, Andrea, Mitchell, Karen, Risley, Michael D, Johnson, Randy, Hirschi, Karen, Lupski, James R, Funato, Yosuke, Miki, Hiroaki, Marin-Garcia, Pablo, Matthews, Lucy, Coffey, Alison J, Parker, Anne, Hubbard, Tim J, Rogers, Jane, Bradley, Allan, Adams, David J, Justice, Monica J

“…An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete DNA sequence and gene…”
Get full text

Discovery of Candidate Disease Genes in ENUaInduced Mouse Mutants by Large-Scale Sequencing, Including a Splice-Site Mutation in Nucleoredoxin by Boles, Melissa K, Wilkinson, Bonney M, Wilming, Laurens G, Liu, Bin, Probst, Frank J, Harrow, Jennifer, Grafham, Darren, Hentges, Kathryn E, Woodward, Lanette P, Maxwell, Andrea, Mitchell, Karen, Risley, Michael D, Johnson, Randy, Hirschi, Karen, Lupski, James R, Funato, Yosuke, Miki, Hiroaki, Marin-Garcia, Pablo, Matthews, Lucy, Coffey, Alison J, Parker, Anne, Hubbard, Tim J, Rogers, Jane, Bradley, Allan, Adams, David J, Justice, Monica J, Beier, David R

“…An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete DNA sequence and gene…”
Get full text

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history by James A Traherne, Roger Horton, Anne N Roberts, Marcos M Miretti, Matthew E Hurles, C Andrew Stewart, Jennifer L Ashurst, Alexey M Atrazhev, Penny Coggill, Sophie Palmer, Jeff Almeida, Sarah Sims, Laurens G Wilming, Jane Rogers, Pieter J de Jong, Mary Carrington, John F Elliott, Stephen Sawcer, John A Todd, John Trowsdale, Stephan Beck

“…The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in…”
Get full text