Search Results - "Willson, T. M."

Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR by Maloney, Patrick R, Parks, Derek J, Haffner, Curt D, Fivush, Adam M, Chandra, Gyan, Plunket, Kelli D, Creech, Katrina L, Moore, Linda B, Wilson, Joan G, Lewis, Michael C, Jones, Stacey A, Willson, Timothy M

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The PPARs:  From Orphan Receptors to Drug Discovery by Willson, Timothy M, Brown, Peter J, Sternbach, Daniel D, Henke, Brad R

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Peroxisome proliferator-activated receptor-δ, a regulator of oxidative capacity, fuel switching and cholesterol transport by FÜRNSINN, C, WILLSON, T. M, BRUNMAIR, B

“…Synthetic agonists of peroxisome proliferator-activated receptor (PPAR)-delta have shown a promising pharmacological profile in preclinical models of metabolic…”
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ AND METABOLIC DISEASE by Willson, Timothy M, Lambert, Millard H, Kliewer, Steven A

“…The nuclear peroxisome proliferator-activated receptor γ (PPARγ) is a transcription factor that is activated by polyunsaturated fatty acids and their…”
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The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation by Ricote, Mercedes, Li, Andrew C, Willson, Timothy M, Kelly, Carolyn J, Glass, Christopher K

“…The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors that is…”
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PPARβ/δ selectively induces differentiation and inhibits cell proliferation by Kim, D J, Bility, M T, Billin, A N, Willson, T M, Gonzalez, F J, Peters, J M

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The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity by Watkins, Ryan E., Wisely, G. Bruce, Moore, Linda B., Collins, Jon L., Lambert, Millard H., Williams, Shawn P., Willson, Timothy M., Kliewer, Steven A., Redinbo, Matthew R.

“…The human nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in…”
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Peroxisome Proliferator-activated Receptors and Hepatic Stellate Cell Activation by Miyahara, Takeo, Schrum, Laura, Rippe, Richard, Xiong, Shigang, Yee, Hal F., Motomura, Kenta, Anania, Frank A., Willson, Timothy M., Tsukamoto, Hidekazu

“…The present study examined the roles of peroxisome proliferator-activated receptors (PPAR) in activation of hepatic stellate cells (HSC), a pivotal event in…”
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Bile Acids: Natural Ligands for an Orphan Nuclear Receptor by Parks, Derek J., Blanchard, Steven G., Bledsoe, Randy K., Chandra, Gyan, Consler, Thomas G., Kliewer, Steven A., Stimmel, Julie B., Willson, Timothy M., Zavacki, Ann Marie, Moore, David D., Lehmann, Jürgen M.

“…Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological…”
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Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ by Milburn, Michael V, Nolte, Robert T, Wisely, G. Bruce, Westin, Stefan, Cobb, Jeffery E, Lambert, Millard H, Kurokawa, Riki, Rosenfeld, Michael G, Willson, Timothy M, Glass, Christopher K

“…The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and…”
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Structural Determinants of Ligand Binding Selectivity between the Peroxisome Proliferator-Activated Receptors by Xu, H. Eric, Lambert, Millard H., Montana, Valerie G., Plunket, Kelli D., Moore, Linda B., Collins, Jon L., Oplinger, Jeffery A., Kliewer, Steven A., Gampe, Robert T., McKee, David D., Moore, John T., Willson, Timothy M.

“…The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of glucose, lipid, and cholesterol metabolism. We report the x-ray…”
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Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase by Glass, Christopher K, Huang, Jannet T, Welch, John S, Ricote, Mercedes, Binder, Christoph J, Willson, Timothy M, Kelly, Carolyn, Witztum, Joseph L, Funk, Colin D, Conrad, Douglas

“…The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent nuclear receptor that has been implicated in the modulation of critical aspects…”
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A new ligand for the peroxisome proliferator-activated receptor-γ (PPAR-γ), GW7845, inhibits rat mammary carcinogenesis by NANJOO SUH, YONGPING WANG, WILLIAMS, C. R, RISINGSONG, R, GILMER, T, WILLSON, T. M, SPORN, M. B

“…We have tested a new ligand for peroxisome proliferator-activated receptor-gamma, GW7845, as an inhibitor of experimental mammary carcinogenesis, using the…”
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A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat by BROWN, K. K, HENKE, B. R, NOVAK, P. J, FAISON, W, BINZ, J. G, HASHIM, M. A, OLIVER, W. O, BROWN, H. R, PARKS, D. J, PLUNKET, K. D, TONG, W.-Q, MENIUS, J. A, BLANCHARD, S. G, ADKISON, K, NOBLE, S. A, WILLSON, T. M, COBB, J. E, MOOK, R, KALDOR, I, KLIEWER, S. A, LEHMANN, J. M, LENHARD, J. M, HARRINGTON, W. W

“…A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. K K…”
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Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine by Poirier, H, Niot, I, Monnot, M C, Braissant, O, Meunier-Durmort, C, Costet, P, Pineau, T, Wahli, W, Willson, T M, Besnard, P

“…Liver fatty-acid-binding protein (L-FABP) is a cytoplasmic polypeptide that binds with strong affinity especially to long-chain fatty acids (LCFAs). It is…”
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The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones by Willson, Timothy M, Cobb, Jeffery E, Cowan, David J, Wiethe, Robert W, Correa, Itzela D, Prakash, Shimoga R, Beck, Kelli D, Moore, Linda B, Kliewer, Steven A, Lehmann, Jürgen M

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Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase by Sastre, Magdalena, Dewachter, Ilse, Landreth, Gary E, Willson, Timothy M, Klockgether, Thomas, van Leuven, Fred, Heneka, Michael T

“…Long-term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk for Alzheimer's disease (AD). To determine the mechanisms by which…”
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Differential activity of rosiglitazone enantiomers at PPARγ by Parks, Derek J., Tomkinson, Nicholas C.O., Villeneuve, Manon S., Blanchard, Steven G., Willson, Timothy M.

“…Analysis of the enantiomers of rosiglitazone in a PPARγ binding assay suggests that the ( S)-(−)-isomer is responsible for the antidiabetic activity. Analysis…”
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Structural Analyses Reveal Phosphatidyl Inositols as Ligands for the NR5 Orphan Receptors SF-1 and LRH- 1 by Krylova, Irina N., Sablin, Elena P., Moore, Jamie, Xu, Robert X., Waitt, Gregory M., MacKay, J. Andrew, Juzumiene, Dalia, Bynum, Jane M., Madauss, Kevin, Montana, Valerie, Lebedeva, Lioudmila, Suzawa, Miyuki, Williams, Jon D., Williams, Shawn P., Guy, Rodney K., Thornton, Joseph W., Fletterick, Robert J., Willson, Timothy M., Ingraham, Holly A.

“…Vertebrate members of the nuclear receptor NR5A subfamily, which includes steroidogenic factor 1 (SF-1) and liver receptor homolog 1 (LRH-1), regulate crucial…”
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Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor by Kast, Heidi R., Goodwin, Bryan, Tarr, Paul T., Jones, Stacey A., Anisfeld, Andrew M., Stoltz, Catherine M., Tontonoz, Peter, Kliewer, Steve, Willson, Timothy M., Edwards, Peter A.

“…The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the apical membrane of the hepatocyte…”
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