Search Results - "Wills, Norma"

Stimulation of stop codon readthrough: frequent presence of an extended 3' RNA structural element by Firth, Andrew E, Wills, Norma M, Gesteland, Raymond F, Atkins, John F

“…In Sindbis, Venezuelan equine encephalitis and related alphaviruses, the polymerase is translated as a fusion with other non-structural proteins via…”
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Tissue-specific dynamic codon redefinition in Drosophila by Hudson, Andrew M., Szabo, Nicholas L., Loughran, Gary, Wills, Norma M., Atkins, John F., Cooley, Lynn

“…Translational stop codon readthrough occurs in organisms ranging from viruses to mammals and is especially prevalent in decoding Drosophila and viral mRNAs…”
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Discovery of a small arterivirus gene that overlaps the GP5 coding sequence and is important for virus production by FIRTH, Andrew E, ZEVENHOVEN-DOBBE, Jessika C, WILLS, Norma M, YUN YOUNG GO, BALASURIYA, Udeni B. R, ATKINS, John F, SNIJDER, Eric J, POSTHUMA, Clara C

“…The arterivirus family (order Nidovirales) of single-stranded, positive-sense RNA viruses includes porcine respiratory and reproductive syndrome virus and…”
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NS1′ of Flaviviruses in the Japanese Encephalitis Virus Serogroup Is a Product of Ribosomal Frameshifting and Plays a Role in Viral Neuroinvasiveness by BALMORI MELIAN, Ezequiel, HINZMAN, Edward, HALL, Roy, KHROMYKH, Alexander A, NAGASAKI, Tomoko, FIRTH, Andrew E, WILLS, Norma M, NOUWENS, Amanda S, BLITVICH, Bradley J, LEUNG, Jason, FUNK, Anneke, ATKINS, John F

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Transcriptional frameshifting rescues Citrobacter rodentium type VI secretion by the production of two length variants from the prematurely interrupted tssM gene by Gueguen, Erwan, Wills, Norma M, Atkins, John F, Cascales, Eric

“…The Type VI secretion system (T6SS) mediates toxin delivery into both eukaryotic and prokaryotic cells. It is composed of a cytoplasmic structure resembling…”
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High-efficiency translational bypassing of non-coding nucleotides specified by mRNA structure and nascent peptide by Samatova, Ekaterina, Konevega, Andrey L., Wills, Norma M., Atkins, John F., Rodnina, Marina V.

“…The gene product 60 (gp60) of bacteriophage T4 is synthesized as a single polypeptide chain from a discontinuous reading frame as a result of bypassing of a…”
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Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5′ mRNA Stem–Loop and Enhanced Drop-off by O'Loughlin, Sinéad, Capece, Mark C., Klimova, Mariia, Wills, Norma M., Coakley, Arthur, Samatova, Ekaterina, O'Connor, Patrick B.F., Loughran, Gary, Weissman, Jonathan S., Baranov, Pavel V., Rodnina, Marina V., Puglisi, Joseph D., Atkins, John F.

“…Efficient translational bypassing of a 50-nt non-coding gap in a phage T4 topoisomerase subunit gene (gp60) requires several recoding signals. Here we…”
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A case for "StopGo": reprogramming translation to augment codon meaning of GGN by promoting unconventional termination (Stop) after addition of glycine and then allowing continued translation (Go) by Atkins, John F, Wills, Norma M, Loughran, Gary, Wu, Chih-Yu, Parsawar, Krishna, Ryan, Martin D, Wang, Chung-Hsiung, Nelson, Chad C

“…When a eukaryotic mRNA sequence specifying an amino acid motif known as 2A is directly followed by a proline codon, two nonoverlapping proteins are…”
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Evidence for ribosomal frameshifting and a novel overlapping gene in the genomes of insect-specific flaviviruses by Firth, Andrew E, Blitvich, Bradley J, Wills, Norma M, Miller, Cathy L, Atkins, John F

“…Abstract Flaviviruses have a positive-sense, single-stranded RNA genome of ∼11 kb, encoding a large polyprotein that is cleaved to produce ∼10 mature proteins…”
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A Functional –1 Ribosomal Frameshift Signal in the Human Paraneoplastic Ma3 Gene by Wills, Norma M., Moore, Barry, Hammer, Andrew, Gesteland, Raymond F., Atkins, John F.

“…A bioinformatics approach to finding new cases of –1 frameshifting in the expression of human genes revealed a classical retrovirus-like heptanucleotide shift…”
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The Interplay of mRNA Stimulatory Signals Required for AUU-Mediated Initiation and Programmed −1 Ribosomal Frameshifting in Decoding of Transposable Element IS911 by PRERE, Marie-Françoise, CANAL, Isabelle, WILLS, Norma M, ATKINS, John F, FAYET, Olivier

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Translational bypassing without peptidyl-tRNA anticodon scanning of coding gap mRNA by Wills, Norma M, O'Connor, Michelle, Nelson, Chad C, Rettberg, Charles C, Huang, Wai Mun, Gesteland, Raymond F, Atkins, John F

“…Half the ribosomes translating the mRNA for phage T4 gene 60 topoisomerase subunit bypass a 50 nucleotide coding gap between codons 46 and 47. The pairing of…”
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The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseases by Wills, Norma M, Atkins, John F

“…Aberrant forms of proteins ubiquitin B and beta-amyloid precusor protein, UBB+1 and APP+1, are implicated in human neurodegenerative diseases. They have their…”
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Programmed ribosomal frameshifting in the expression of the regulator of intestinal stem cell proliferation, adenomatous polyposis coli (APC) by Baranov, Pavel V., Wills, Norma M., Barriscale, Kathy A., Firth, Andrew E., Jud, Molly C., Letsou, Anthea, Manning, Gerard, Atkins, John F.

“…A programmed ribosomal frameshift (PRF) in the decoding of APC (adenomatous polyposis coli) mRNA has been identified and characterized in Caenorhabditis worms,…”
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Nonlinearity in Genetic Decoding: Homologous DNA Replicase Genes Use Alternatives of Transcriptional Slippage or Translational Frameshifting by Larsen, Bente, Wills, Norma M., Nelson, Chad, Atkins, John F., Gesteland, Raymond F.

“…The τ and γ subunits of DNA polymerase III are both encoded by a single gene in Escherichia coli and Thermus thermophilus. γ is two-thirds the size of τ and…”
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Analysis of the roles of tRNA structure, ribosomal protein L9, and the bacteriophage T4 gene 60 bypassing signals during ribosome slippage on mRNA by Herr, Alan J, Nelson, Chad C, Wills, Norma M, Gesteland, Raymond F, Atkins, John F

“…A 50-nucleotide coding gap divides bacteriophage T4 gene 60 into two open reading frames. In response to cis-acting stimulatory signals encrypted in the mRNA,…”
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Factors that influence selection of coding resumption sites in translational bypassing: minimal conventional peptidyl-tRNA:mRNA pairing can suffice by Herr, Alan J, Wills, Norma M, Nelson, Chad C, Gesteland, Raymond F, Atkins, John F

“…This study investigates bypassing initiated from codons immediately 5' of a stop codon. The mRNA slips and is scanned by the peptidyl-tRNA for a suitable…”
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P-site Pairing Subtleties Revealed by the Effects of Different tRNAs on Programmed Translational Bypassing where Anticodon Re-pairing to mRNA is Separated from Dissociation by Bucklin, Douglas J., Wills, Norma M., Gesteland, Raymond F., Atkins, John F.

“…Programmed ribosomal bypassing occurs in decoding phage T4 gene 60 mRNA. Half the ribosomes bypass a 50 nucleotide gap between codons 46 and 47. Peptidyl-tRNA…”
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Folding of an mRNA Pseudoknot Required for Stop Codon Readthrough:  Effects of Mono- and Divalent Ions on Stability by Gluick, Thomas C, Wills, Norma M, Gesteland, Raymond F, Draper, David E

“…Unfolding of an mRNA pseudoknot that induces ribosome suppression of the gag gene stop codon in Moloney murine leukemia virus has been studied by UV…”
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1 Frameshifting at a CGA AAG Hexanucleotide Site Is Required for Transposition of Insertion Sequence IS1222 by MEJLHEDE, Nina, LICZNAR, Patricia, PRERE, Marie-Francoise, WILLS, Norma M, GESTELAND, Raymond F, ATKINS, John F, FAYET, Olivier

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