Search Results - "Wills, N K"

Coexpression of complementary fragments of ClC-5 and restoration of chloride channel function in a Dent's disease mutation by Mo, L, Xiong, W, Qian, T, Sun, H, Wills, N K

“…The human hereditary disorder Dent's disease is linked to loss-of-function mutations of the chloride channel ClC-5. Many of these mutations involve insertion…”
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Oxidant and antioxidant modulation of chloride channels expressed in human retinal pigment epithelium by Weng, T X, Godley, B F, Jin, G F, Mangini, N J, Kennedy, B G, Yu, A S L, Wills, N K

“…Retinal pigment epithelium (RPE) possesses regulated chloride channels that are crucial for transepithelial fluid and ion transport. At present, little is…”
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ClC Chloride Channels in Epithelia: Recent Progress and Remaining Puzzles by Wills, N. K, Fong, P

“…N. K. Wills 1 and P. Fong 2 1 Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77551; and 2 Department of…”
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Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer by CHENEY, I. W, JOHNSON, D. E, BOOKSTEIN, R, VAILLANCOURT, M.-T, AVANZINI, J, MORIMOTO, A, DEMERS, G. W, WILLS, K. N, SHABRAM, P. W, BOLEN, J. B, TAVTIGIAN, S. V

“…Mutated in multiple advanced cancers 1/phosphatase and tensin homologue (MMAC1/PTEN) is a novel tumor suppressor gene candidate located on chromosome 10 that…”
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p53 gene therapy in a rat model of hepatocellular carcinoma: intra-arterial delivery of a recombinant adenovirus by ANDERSON, S. C, JOHNSON, D. E, LOFGREN, S, SHEPARD, H. M, MANEVAL, D. C, HARRIS, M. P, ENGLER, H, HANCOCK, W, HUANG, W.-M, WILLS, K. N, GREGORY, R. J, SUTJIPTO, S, SHU FEN WEN

“…p53 tumor suppressor gene therapy has been proposed for cancers characterized by inactivation of p53 function, and successful therapy will require efficient…”
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Rb functions to inhibit apoptosis during myocyte differentiation by WANG, J, GUO, K, WILLS, K. N, WALSH, K

“…During in vitro myogenesis, a portion of myoblasts undergo apoptosis, whereas others continue with their differentiation program and form myotubes that are…”
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Novel pathway for thyroid hormone receptor action through interaction with jun and fos oncogene activities by XIAO-KUN ZHANG, WILLS, K. N, HUSMANN, M, HERMANN, T, PFAHL, M

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Adenoviral constructs encoding phosphorylation-competent full-length and truncated forms of the human retinoblastoma protein inhibit myocyte proliferation and neointima formation by SMITH, R. C, WILLS, K. N, ANTELMAN, D, PERLMAN, H, TRUONG, L. N, KRASINSKI, K, WALSH, K

“…The retinoblastoma (Rb) protein is a key cell-cycle regulator that controls entry into the S phase by modulating the activity of the E2F transcription factor…”
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Intratumoral Spread and Increased Efficacy of a p53-VP22 Fusion Protein Expressed by a Recombinant Adenovirus by Wills, K N, Atencio, I A, Avanzini, J B, Neuteboom, S, Phelan, A, Philopena, J, Sutjipto, S, Vaillancourt, M T, Wen, S F, Ralston, R O, Johnson, D E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tissue-specific expression of an anti-proliferative hybrid transgene from the human smooth muscle α-actin promoter suppresses smooth muscle cell proliferation and neointima formation by WILLS, K. N, MANO, T, AVANZINI, J. B, NGUYEN, T, ANTELMAN, D, GREGORY, R. J, SMITH, R. C, WALSH, K

“…The retinoblastoma protein (Rb), a key regulator of cell cycle progression, can bind the transcription factor E2F converting it from a positive transcriptional…”
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Expression and regulation of ClC-5 chloride channels: effects of antisense and oxidants by Weng, T X, Mo, L, Hellmich, H L, Yu, A S, Wood, T, Wills, N K

“…Genetic mutations of the Cl(-) channel ClC-5 cause Dent's disease in humans. We recently cloned an amphibian ortholog of Xenopus ClC-5 (xClC-5) from the A6…”
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Copper and zinc distribution in the human retina: Relationship to cadmium accumulation, age, and gender by Wills, N.K., Sadagopa Ramanujam, V.M., Kalariya, N., Lewis, J.R., van Kuijk, F.J.G.M.

“…The essential metals copper and zinc play vital roles in retinal cell survival and are crucial for the normal functioning of antioxidant enzymes. Retinal zinc…”
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Adenovirus‐mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo by Köck, Helge, Harris, Matthew P., Anderson, Scott C., Machemer, Todd, Hancock, Wendy, Sutjipto, Suganto, Wills, Ken N., Gregory, Richard J., Shepard, H. Michael, Westphal, Manfred, Maneval, Daniel C.

“…Alterations in the p53 tumor‐suppressor gene occur in 35–60% of human glioblastomas, and re‐introduction of p53 can suppress neoplastic growth. To evaluate the…”
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Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity by Graupner, Gerhart, Wills, Ken N, Tzukerman, Maty, Zhang, Xiao-kun, Pfahl, Magnus

“…Both thyroid hormone (T3) and retinoic acid signal essential steps in development, differentiation and morphogenesis. Specific nuclear receptors for these…”
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A spectroscopic method for assessing confluence of epithelial cell cultures by Jovov, B, Wills, N K, Lewis, S A

“…We describe a convenient nonelectrophysiological technique for assessing cell proliferation and subsequent tight junction formation for epithelial monolayers…”
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Chloride Channel Expression in Cultured Human Fetal RPE Cells: Response to Oxidative Stress by Wills, Nancy K, Weng, Tianxiang, Mo, Lijun, Hellmich, Helen L, Yu, Alan, Wang, Ting, Buchheit, Sarah, Godley, Bernard F

“…The human fetal cell line RPE 28 SV4 has been useful for studies of oxidative stress and apoptosis in retinal pigmented epithelium. This cell model is now…”
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Cadmium accumulation in the human retina: Effects of age, gender, and cellular toxicity by Wills, N.K., Ramanujam, V.M. Sadagopa, Chang, J., Kalariya, N., Lewis, J.R., Weng, T.-X., van Kuijk, F.J.G.M.

“…Tobacco smoking and aging are among the few factors linked to age-related macular degeneration (AMD), a major cause of blindness in the elderly. Recent studies…”
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Human retinal cadmium accumulation as a factor in the etiology of age-related macular degeneration by Wills, N.K., Kalariya, N., Sadagopa Ramanujam, V.M., Lewis, J.R., Haji Abdollahi, S., Husain, A., van Kuijk, F.J.G.M.

“…Cadmium is a naturally occurring, highly toxic, metallic element. It pollutes the environment as a result of industrial activity and accumulates in human…”
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Comparison of amphibian and human ClC-5: similarity of functional properties and inhibition by external pH by Mo, L, Hellmich, H L, Fong, P, Wood, T, Embesi, J, Wills, N K

“…Loss of function mutations of the renal chloride channel, ClC-5, have been implicated in Dent's disease, a genetic disorder characterized by low weight…”
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Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene by Wills, K N, Huang, W M, Harris, M P, Machemer, T, Maneval, D C, Gregory, R J

“…We have investigated whether adenovirally mediated gene transfer of the herpes simplex thymidine kinase gene to human hepatocellular carcinoma (HCC) cell lines…”
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