Search Results - "Willoughby, Karen A"

Effects of maternal hypothyroidism on offspring hippocampus and memory by Willoughby, Karen A, McAndrews, Mary Pat, Rovet, Joanne F

“…Rodents with gestational thyroid-hormone (TH) deficiencies and children with congenital hypothyroidism show abnormal hippocampal development. Given that the…”
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Episodic and Semantic Autobiographical Memory and Everyday Memory during Late Childhood and Early Adolescence by Willoughby, Karen A, Desrocher, Mary, Levine, Brian, Rovet, Joanne F

“…Few studies have examined both episodic and semantic autobiographical memory (AM) performance during late childhood and early adolescence. Using the newly…”
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Activation of Extracellular Signal-Regulated Kinase by Stretch-Induced Injury in Astrocytes Involves Extracellular ATP and P2 Purinergic Receptors by Neary, Joseph T, Kang, Yuan, Willoughby, Karen A, Ellis, Earl F

“…Gliosis is characterized by hypertrophic and hyperplastic responses of astrocytes to brain injury. To determine whether injury of astrocytes produced by an in…”
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Accuracy of episodic autobiographical memory in children with early thyroid hormone deficiency using a staged event by WILLOUGHBY, Karen A, MCANDREWS, Mary Pat, ROVET, Joanne F

“…Autobiographical memory (AM) is a highly constructive cognitive process that often contains memory errors. No study has specifically examined AM accuracy in…”
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Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood by Willoughby, Karen A, Sheard, Erin D, Nash, Kelly, Rovet, Joanne

“…Children with prenatal alcohol exposure (PAE) show deficits in verbal learning and spatial memory, as well as abnormal hippocampal development. The…”
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Hippocampal Size and Memory Functioning in Children and Adolescents with Congenital Hypothyroidism by Wheeler, Sarah M, Willoughby, Karen A, McAndrews, Mary Pat, Rovet, Joanne F

“…Background: Despite early diagnosis and treatment of congenital hypothyroidism (CH) after newborn screening, selective and persistent neurocognitive weaknesses…”
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Effects of early thyroid hormone deficiency on children's autobiographical memory performance by Willoughby, Karen A, McAndrews, Mary Pat, Rovet, Joanne

“…Memory deficits and hippocampal abnormalities have been described in individuals with thyroid hormone (TH) insufficiencies; however, no study has yet examined…”
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Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes by Floyd, Candace L, Rzigalinski, Beverly A, Sitterding, Heather A, Willoughby, Karen A, Ellis, Earl F

“…We have previously found that in vitro traumatic injury uncouples IP3-mediated intracellular free calcium ([Ca2+]i) signaling in astrocytes (Rzigalinski et…”
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Neuroplastic effects of music lessons on hippocampal volume in children with congenital hypothyroidism by Zendel, Benjamin Rich, Willoughby, Karen A, Rovet, Joanne F

“…Children with congenital hypothyroidism (CH) who experience a neonatal thyroid hormone deficiency have reduced hippocampal volumes compared with healthy…”
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S100B protein is released from rat neonatal neurons, astrocytes, and microglia by in vitro trauma and anti-S100 increases trauma-induced delayed neuronal injury and negates the protective effect of exogenous S100B on neurons by Ellis, Earl F, Willoughby, Karen A, Sparks, Sallie A, Chen, Tao

“…S100B protein is found in brain, has been used as a marker for brain injury and is neurotrophic. Using a well-characterized in vitro model of brain cell…”
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Assessing students' perceptions of the effects of a new Canadian longitudinal pre-clerkship family medicine experience by Willoughby, Karen A., Rodríguez, Charo, Boillat, Miriam, Dove, Marion, Nugus, Peter, Steinert, Yvonne, Lalla, Leonora

“…Background: Despite the implementation of longitudinal community-based pre-clerkship courses in several Canadian medical schools, there is a paucity of data…”
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S100B protein is released by in vitro trauma and reduces delayed neuronal injury by Willoughby, Karen A., Kleindienst, Andrea, Müller, Christian, Chen, Tao, Muir, Judith K., Ellis, Earl F.

“…S100B protein in brain is produced primarily by astrocytes, has been used as a marker for brain injury and has also been shown to be neurotrophic and…”
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Calcium Influx Factor, Further Evidence It Is 5,6-Epoxyeicosatrienoic Acid by Rzigalinski, Beverly A., Willoughby, Karen A., Hoffman, Stuart W., Falck, J.R., Ellis, Earl F.

“…We present evidence in astrocytes that 5,6-epoxyeicosatrienoic acid, a cytochrome P450 epoxygenase metabolite of arachidonic acid, may be a component of…”
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The biodisposition and metabolism of anandamide in mice by Willoughby, K A, Moore, S F, Martin, B R, Ellis, E F

“…The endogenous cannabinoid anandamide (AN) has been reported to produce pharmacological effects similar to those of delta9-tetrahydrocannabinol but with a…”
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Group I metabotropic receptor antagonism blocks depletion of calcium stores and reduces potentiated capacitative calcium entry in strain-injured neurons and astrocytes by Chen, Tao, Willoughby, Karen A, Ellis, Earl F

“…Antagonism of the group I metabotropic receptor subtype 1 (mGluR1) with (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) has been shown to reduce deficits after…”
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NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neurons by Ahmed, Syed M, Weber, John T, Liang, Shi, Willoughby, Karen A, Sitterding, Heather A, Rzigalinski, Beverly A, Ellis, Earl F

“…In our previous studies, we have shown that in vitro biaxial strain (stretch) injury of neurons in neuronal plus glial cultures increases intracellular free…”
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Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling by Floyd, Candace L., Rzigalinski, Beverly A., Weber, John T., Sitterding, Heather A., Willoughby, Karen A., Ellis, Earl F.

“…Our previous studies using an in vitro model of traumatic injury have shown that stretch injury of astrocytes causes a rapid elevation in intracellular free…”
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Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes by Amruthesh, S C, Boerschel, M F, McKinney, J S, Willoughby, K A, Ellis, E F

“…We have recently shown that brain slices are capable of metabolizing arachidonic acid by the epoxygenase pathway. The purpose of this study was to begin to…”
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Effect of Ca2+ on In Vitro Astrocyte Injury by Rzigalinski, Beverly A., Liang, Shi, McKinney, Jerry S., Willoughby, Karen A., Ellis, Earl F.

“…: Current literature suggests that a massive influx of Ca2+ into the cells of the CNS induces cell damage associated with traumatic brain injury (TBI). Using…”
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Stretch‐Induced Injury Alters Mitochondrial Membrane Potential and Cellular ATP in Cultured Astrocytes and Neurons by Ahmed, Syed M., Rzigalinski, Beverly A., Willoughby, Karen A., Sitterding, Heather A., Ellis, Earl F.

“…: Energy deficit after traumatic brain injury (TBI) may alter ionic homeostasis, neurotransmission, biosynthesis, and cellular transport. Using an in vitro…”
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