Search Results - "Willnow, T E"

SorCS2 is required for BDNF-dependent plasticity in the hippocampus by Glerup, S, Bolcho, U, Mølgaard, S, Bøggild, S, Vaegter, C B, Smith, A H, Nieto-Gonzalez, J L, Ovesen, P L, Pedersen, L F, Fjorback, A N, Kjolby, M, Login, H, Holm, M M, Andersen, O M, Nyengaard, J R, Willnow, T E, Jensen, K, Nykjaer, A

“…SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic…”
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Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA by Eggert, Simone, Gonzalez, A. C., Thomas, C., Schilling, S., Schwarz, S. M., Tischer, C., Adam, V., Strecker, P., Schmidt, V., Willnow, T. E., Hermey, G., Pietrzik, C. U., Koo, E. H., Kins, Stefan

“…Proteolytic cleavage of the amyloid precursor protein (APP) by α-, β- and γ-secretases is a determining factor in Alzheimer’s disease (AD). Imbalances in the…”
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Mutually dependent localization of megalin and Dab2 in the renal proximal tubule by Nagai, J, Christensen, E I, Morris, S M, Willnow, T E, Cooper, J A, Nielsen, R

“…Disabled-2 (Dab2) is a cytoplasmic adaptor protein that binds to the cytoplasmic tail of the multiligand endocytic receptor megalin, abundantly expressed in…”
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A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction by Gailly, P., Jouret, F., Martin, D., Debaix, H., Parreira, K.S., Nishita, T., Blanchard, A., Antignac, C., Willnow, T.E., Courtoy, P.J., Scheinman, S.J., Christensen, E.I., Devuyst, O.

“…Dysfunction of the proximal tubule (PT) is associated with variable degrees of solute wasting and low-molecular-weight proteinuria. We measured metabolic…”
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RAP, a specialized chaperone, prevents ligand‐induced ER retention and degradation of LDL receptor‐related endocytic receptors by Willnow, T. E., Rohlmann, A., Horton, J., Otani, H., Braun, J. R., Hammer, R. E., Herz, J.

“…The multifunctional low density lipoprotein (LDL) receptor‐related protein (LRP) forms a complex with a receptor‐associated protein (RAP) within the secretory…”
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Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria by Leheste, Jörg-Robert, Rolinski, Boris, Vorum, Henrik, Hilpert, Jan, Nykjaer, Anders, Jacobsen, Christian, Aucouturier, Pierre, Moskaug, Jan Øivind, Otto, Albrecht, Christensen, Erik Ilsø, Willnow, Thomas E.

“…Megalin is an endocytic receptor expressed on the luminal surface of the renal proximal tubules. The receptor is believed to play an important role in the…”
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Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo by Willnow, T.E. (University of Texas Southeastern Medical Center, Dallas, TX.), Armstrong, S.A, Hammer, R.E, Herz, J

“…The 39-kDa receptor-associated protein (RAP) associates with the multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) and thereby…”
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Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance by WILLNOW, T. E, GOLDSTEIN, J. L, ORTH, K, BROWN, M. S, HERZ, J

“…The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP) and gp330, two members of the low density lipoprotein receptor gene…”
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Defective Forebrain Development in Mice Lacking gp330/Megalin by Willnow, Thomas E., Hilpert, Jan, Armstrong, Scott A., Rohlmann, Astrid, Hammer, Robert E., Burns, Dennis K., Herz, Joachim

“…gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the…”
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Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11 by Spoelgen, R, Adams, K.W, Koker, M, Thomas, A.V, Andersen, O.M, Hallett, P.J, Bercury, K.K, Joyner, D.F, Deng, M, Stoothoff, W.H, Strickland, D.K, Willnow, T.E, Hyman, B.T

“…Abstract In this study, we examined protein–protein interactions between two neuronal receptors, low density lipoprotein receptor-related protein (LRP) and…”
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The low-density lipoprotein receptor gene family : multiple roles in lipid metabolism by WILLNOW, T. E

“…The low-density lipoprotein receptor gene family encompasses a class of endocytic receptors that exhibit structural similarities to the low-density lipoprotein…”
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Evidence for an essential role of megalin in transepithelial transport of retinol by CHRISTENSEN, E. I, MOSKAUG, J. Ø, VORUM, H, JACOBSEN, C, GUNDERSEN, T. E, NYKJAER, A, BLOMHOFF, R, WILLNOW, T. E, MOESTRUP, S. K

“…Transepithelial transport of retinol is linked to retinol-binding protein (RBP), which is taken up and also synthesized in a number of epithelia. By…”
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Essential role of megalin in renal proximal tubule for vitamin homeostasis by CHRISTENSEN, E. I, WILLNOW, T. E

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Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A : evidence that this protein is required for uptake and degradation of multiple ligands by WILLNOW, T. E, HERZ, J

“…The low density lipoprotein receptor-related protein (LRP) is a large multifunctional receptor implicated in the cellular uptake of functionally diverse…”
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Endocytosis of sex steroids: The hypothesis of free hormones revisited by Willnow, T.E, Hammes, A, Nykjaer, A

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Sustained somatic gene inactivation by viral transfer of Cre recombinase by Rohlmann, Astrid, Gotthardt, Michael, Willnow, Thomas E, Hammer, Robert E, Herz, Joachim

“…Transgenic and knockout mice have proven invaluable tools for analyzing physiologically relavant functions of numerous genes. In some cases, however,…”
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Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein by Willnow, T E, Orth, K, Herz, J

“…The low density lipoprotein receptor-related protein (LRP) is a large multifunctional receptor that is involved in the cellular uptake of a number of…”
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Efficient eukaryotic expression system for authentic human sex hormone-binding globulin by Hilpert, J, Vorum, H, Burmeister, R, Spoelgen, R, Grishkovskaya, I, Misselwitz, R, Nykjaer, A, Willnow, T E

“…Sex hormone-binding globulin (SHBG) is the main carrier for androgens and oestrogens in humans. It mediates the transport of steroid hormones in the…”
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Cellular uptake of lipoprotein[a] by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein by Reblin, T, Niemeier, A, Meyer, N, Willnow, T E, Kronenberg, F, Dieplinger, H, Greten, H, Beisiegel, U

“…The sites and precise mechanisms of the catabolism of the atherogenic lipoprotein[a] (Lp[a]) are unknown. It has been proposed that the low density lipoprotein…”
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Lipoprotein receptors: new roles for ancient proteins by Nykjaer, Anders, Willnow, Thomas E, Herz, Joachim

“…Lipoprotein receptors used to be viewed simply as the means by which cells were supplied with lipids for energy production and membrane synthesis. This…”
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