Search Results - "Willis, N."

Life in the balance: how BH3-only proteins induce apoptosis by Willis, Simon N, Adams, Jerry M

“…BH3-only members of the Bcl-2 intracellular protein family, which include Bim, Bmf, Bik, Bad, Bid, Puma, Noxa and Hrk, mediate many developmentally programmed…”
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Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells by Shi, Wei, Liao, Yang, Willis, Simon N, Taubenheim, Nadine, Inouye, Michael, Tarlinton, David M, Smyth, Gordon K, Hodgkin, Philip D, Nutt, Stephen L, Corcoran, Lynn M

“…The process of B cell differentiation into plasma cells involves dramatic cellular reprogramming. Corcoran and colleagues profile the transcriptome of all…”
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New players in the gene regulatory network controlling late B cell differentiation by Willis, Simon N, Nutt, Stephen L

“…•Multiple intrinsic and extrinsic inputs control B cell terminal differentiation.•Differentiation is associated with loss of CpG methylation at…”
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Performing in Uncertain Operating Environments: Buffer Inventory, Volume Flexibility or Both? by Mwangola, Willis N., Mackelprang, Alan W., Burke, Gerard J.

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Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials by Ashor, A W, Werner, A D, Lara, J, Willis, N D, Mathers, J C, Siervo, M

“…Randomised controlled trials (RCTs) have observed contrasting results on the effects of vitamin C on circulating biomarkers of glycaemic and insulin…”
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Human health risk assessment of heavy metal concentration in surface water of Sosian river, Eldoret town, Uasin-Gishu County Kenya by Munene, Emily N., Hashim, Nadir O., Ambusso, Willis N.

“…Heavy metal pollution in surface waters has become a major worldwide issue as people tend to settle where there is readily available source of water like a…”
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Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB by Willis, Simon N., Tellier, Julie, Liao, Yang, Trezise, Stephanie, Light, Amanda, O’Donnell, Kristy, Garrett-Sinha, Lee Ann, Shi, Wei, Tarlinton, David M., Nutt, Stephen L.

“…Humoral immunity requires B cells to respond to multiple stimuli, including antigen, membrane and soluble ligands, and microbial products. Ets family…”
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IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos by Fedele, Pasquale L., Willis, Simon N., Liao, Yang, Low, Michael S., Rautela, Jai, Segal, David H., Gong, Jia-Nan, Huntington, Nicholas D., Shi, Wei, Huang, David C.S., Grigoriadis, George, Tellier, Julie, Nutt, Stephen L.

“…Recent studies have demonstrated that the immunomodulatory drugs (IMiDs) lead to the degradation of the transcription factors Ikaros and Aiolos. However, why…”
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The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation by Carotta, Sebastian, Willis, Simon N, Hasbold, Jhagvaral, Inouye, Michael, Pang, Swee Heng Milon, Emslie, Dianne, Light, Amanda, Chopin, Michael, Shi, Wei, Wang, Hongsheng, Morse, 3rd, Herbert C, Tarlinton, David M, Corcoran, Lynn M, Hodgkin, Philip D, Nutt, Stephen L

“…Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes…”
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IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis by Low, Michael Sze Yuan, Brodie, Erica J., Fedele, Pasquale L., Liao, Yang, Grigoriadis, George, Strasser, Andreas, Kallies, Axel, Willis, Simon N., Tellier, Julie, Shi, Wei, Gabriel, Sarah, O’Donnell, Kristy, Pitt, Catherine, Nutt, Stephen L., Tarlinton, David

“…The transcription factor interferon regulatory factor 4 (IRF4) is critical for the development, maintenance, and function of plasma cells. The mechanism by…”
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Factors influencing delayed clearance of high dose methotrexate (HDMTX) in pediatric, adolescent, and young adult oncology patients by Mosleh, Ema, Snyder, Stacy, Wu, Ningying, Willis, Daniel N, Malone, Rema, Hayashi, Robert J

“…To identify modifiable risk factors associated with prolonged clearance of methotrexate in pediatric, adolescent, and young adult (AYA) oncology patients…”
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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized by van Delft, Mark F., Wei, Andrew H., Mason, Kylie D., Vandenberg, Cassandra J., Chen, Lin, Czabotar, Peter E., Willis, Simon N., Scott, Clare L., Day, Catherine L., Cory, Suzanne, Adams, Jerry M., Roberts, Andrew W., Huang, David C.S.

“…Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural antagonists, BH3-only proteins, might…”
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Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism by Willis, Simon N, Good-Jacobson, Kim L, Curtis, Joan, Light, Amanda, Tellier, Julie, Shi, Wei, Smyth, Gordon K, Tarlinton, David M, Belz, Gabrielle T, Corcoran, Lynn M, Kallies, Axel, Nutt, Stephen L

“…In response to antigenic stimulation, mature B cells interact with follicular helper T cells in specialized structures called germinal centers (GCs), which…”
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Corrigendum: Factors influencing delayed clearance of high dose methotrexate (HDMTX) in pediatric, adolescent, and young adult oncology patients by Mosleh, Ema, Snyder, Stacy, Wu, Ningying, Willis, Daniel N, Malone, Rema, Hayashi, Robert J

“…[This corrects the article DOI: 10.3389/fonc.2023.1280587.]…”
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Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1 by Kvansakul, Marc, Wei, Andrew H, Fletcher, Jamie I, Willis, Simon N, Chen, Lin, Roberts, Andrew W, Huang, David C S, Colman, Peter M

“…Epstein-Barr virus (EBV) is associated with human malignancies, especially those affecting the B cell compartment such as Burkitt lymphoma. The virally encoded…”
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Prevention and treatment of renal disease in Henoch-Schönlein purpura: a systematic review by Chartapisak, W, Opastiraku, S L, Willis, N S, Craig, J C, Hodson, E M

“…Objective:To determine the benefits and harms of therapies used to prevent or treat renal involvement in Henoch-Schönlein purpura.Design:Systematic review of…”
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Mortality in pediatric oncology and stem cell transplant patients with bloodstream infections by Willis, Daniel N, McGlynn, Mary Claire, Reich, Patrick J, Hayashi, Robert J

“…Bloodstream infections (BSI) continue to represent a significant source of morbidity for pediatric oncology patients, however less is known regarding this…”
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An arrayed CRISPR screen of primary B cells reveals the essential elements of the antibody secretion pathway by Trezise, Stephanie, Kong, Isabella Y, Hawkins, Edwin D, Herold, Marco J, Willis, Simon N, Nutt, Stephen L

“…Humoral immunity depends on the differentiation of B cells into antibody secreting cells (ASCs). Excess or inappropriate ASC differentiation can lead to…”
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Antibiotics for acute pyelonephritis in children by Hodson, E M, Willis, N S, Craig, J C

“…Urinary tract infection (UTI) is one of the most common bacterial infection in infants. The most severe form of UTI is acute pyelonephritis, which results in…”
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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1 by Puthalakath, Hamsa, Smyth, Mark J, Motoyama, Noboru, Strasser, Andreas, Huang, David C S, Dewson, Grant, Tarlinton, David M, Willis, Simon N, Tabarias, Hyacinth, Huntington, Nicholas D, Degli-Esposti, Mariapia A, Michalak, Ewa M, Nutt, Stephen L, Gunn, Priscilla, Naik, Edwina

“…Interleukin 15 (IL-15) promotes the survival of natural killer (NK) cells by preventing apoptosis through mechanisms unknown at present. Here we identify Bim,…”
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