Search Results - "Willis, Gareth"

Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation by Willis, Gareth R, Fernandez-Gonzalez, Angeles, Anastas, Jamie, Vitali, Sally H, Liu, Xianlan, Ericsson, Maria, Kwong, April, Mitsialis, S Alex, Kourembanas, Stella

“…Mesenchymal stem/stromal cell (MSC) therapies have shown promise in preclinical models of pathologies relevant to newborn medicine, such as bronchopulmonary…”
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Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension? by Willis, Gareth R, Fernandez-Gonzalez, Angeles, Reis, Monica, Mitsialis, S Alex, Kourembanas, Stella

“…Pulmonary arterial hypertension (PAH) is a progressive disease characterized by remodeling of the pulmonary arteries, increased pulmonary infiltrates, loss of…”
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Toward Exosome-Based Therapeutics: Isolation, Heterogeneity, and Fit-for-Purpose Potency by Willis, Gareth R, Kourembanas, Stella, Mitsialis, S Alex

“…Exosomes are defined as submicron (30-150 nm), lipid bilayer-enclosed extracellular vesicles (EVs), specifically generated by the late endosomal compartment…”
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“Good things come in small packages”: application of exosome-based therapeutics in neonatal lung injury by Willis, Gareth R, Mitsialis, S Alex, Kourembanas, Stella

“…Infants born at very low gestational age contribute disproportionately to neonatal morbidity and mortality. Advancements in antenatal steroid therapies and…”
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Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes by Mansouri, Nahal, Willis, Gareth R, Fernandez-Gonzalez, Angeles, Reis, Monica, Nassiri, Sina, Mitsialis, S Alex, Kourembanas, Stella

“…Mesenchymal stromal/stem cell (MSC) therapy has shown promise in experimental models of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test…”
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Extracellular Vesicles Protect the Neonatal Lung from Hyperoxic Injury through the Epigenetic and Transcriptomic Reprogramming of Myeloid Cells by Willis, Gareth R, Reis, Monica, Gheinani, Ali Hashemi, Fernandez-Gonzalez, Angeles, Taglauer, Elizabeth S, Yeung, Vincent, Liu, Xianlan, Ericsson, Maria, Haas, Eric, Mitsialis, S Alex, Kourembanas, Stella

“…Mesenchymal stem/stromal cell (MSC)-small extracellular vesicle (MEx) treatment has shown promise in experimental models of neonatal lung injury. The molecular…”
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Antenatal Mesenchymal Stromal Cell Extracellular Vesicle Therapy Prevents Preeclamptic Lung Injury in Mice by Taglauer, Elizabeth S, Fernandez-Gonzalez, Angeles, Willis, Gareth R, Reis, Monica, Yeung, Vincent, Liu, Xianlan, Prince, Lawrence S, Mitsialis, S Alex, Kourembanas, Stella

“…In preeclamptic pregnancies, a variety of intrauterine alterations lead to abnormal placentation, release of inflammatory and/or antiangiogenic factors, and…”
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Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension by Fernandez-Gonzalez, Angeles, Mukhia, Amit, Nadkarni, Janhavi, Willis, Gareth R, Reis, Monica, Zhumka, Kristjan, Vitali, Sally, Liu, Xianlan, Galls, Alexandra, Mitsialis, S Alex, Kourembanas, Stella

“…Macrophages play a significant role in the onset and progression of vascular disease in pulmonary hypertension, and cell-based immunotherapies aimed at…”
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Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension by Hudalla, Hannes, Michael, Zoe, Christodoulou, Nicolas, Willis, Gareth R, Fernandez-Gonzalez, Angeles, Filatava, Evgenia J, Dieffenbach, Paul, Fredenburgh, Laura E, Stearman, Robert S, Geraci, Mark W, Kourembanas, Stella, Christou, Helen

“…Inflammation and vascular smooth muscle cell (VSMC) phenotypic switching are causally linked to pulmonary arterial hypertension (PAH) pathogenesis. Carbonic…”
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Mesenchymal stromal cell-derived extracellular vesicle therapy prevents preeclamptic physiology through intrauterine immunomodulation by Taglauer, Elizabeth S., Fernandez-Gonzalez, Angeles, Willis, Gareth R., Reis, Monica, Yeung, Vincent, Liu, Xianlan, Mitsialis, S. Alex, Kourembanas, Stella

“…Human umbilical cord-derived mesenchymal stromal cells (MSCs) are a widely recognized treatment modality for a variety of preclinical disease models and have…”
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia by Reis, Monica, Willis, Gareth R, Fernandez-Gonzalez, Angeles, Yeung, Vincent, Taglauer, Elizabeth, Magaletta, Margaret, Parsons, Teagan, Derr, Alan, Liu, Xianlan, Maehr, Rene, Kourembanas, Stella, Mitsialis, S Alex

“…Treating premature infants with high oxygen is a routine intervention in the context of neonatal intensive care. Unfortunately, the increase in survival rates…”
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Therapeutic Applications of Extracellular Vesicles: Perspectives from Newborn Medicine by Willis, Gareth R, Kourembanas, Stella, Mitsialis, S Alex

“…With the advancements in antenatal steroid therapies and surfactant replacement, current clinical practices in neonatal intensive care units allow the survival…”
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Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung injury by Willis, Gareth R., Fernandez-Gonzalez, Angeles, Reis, Monica, Yeung, Vincent, Liu, Xianlan, Ericsson, Maria, Andrews, Nick A., Mitsialis, S. Alex, Kourembanas, Stella

“…Early administration of mesenchymal stromal cell (MSC)-derived small extracellular vesicles (MEx) has shown considerable promise in experimental models of…”
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Nitrate pharmacokinetics: Taking note of the difference by James, Philip E., Willis, Gareth R., Allen, Jason D., Winyard, Paul G., Jones, Andrew M.

“…•We highlight key considerations for new and current researchers; a prologue to this special issue of the Nitric Oxide Journal.•We attempt to strike an…”
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Reply to Muraca et al.: Exosome Treatment of Bronchopulmonary Dysplasia: How Pure Should Your Exosome Preparation Be? by Mitsialis, S Alex, Willis, Gareth R, Fernandez-Gonzalez, Angeles, Kourembanas, Stella

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Time to think small: Using extracellular vesicles to assess the effects of long-term opioid use by Withey, Sarah L, Willis, Gareth R

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Therapeutic Effects of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Oxygen-Induced Multi-Organ Disease: A Developmental Perspective by Fernandez-Gonzalez, Angeles, Willis, Gareth R, Yeung, Vincent, Reis, Monica, Liu, Xianlan, Mitsialis, S Alex, Kourembanas, Stella

“…Despite major advances in neonatal intensive care, infants born at extremely low birth weight still face an increased risk for chronic illness that may persist…”
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Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia[S] by Connolly, Katherine D., Willis, Gareth R., Datta, Dev B.N., Ellins, Elizabeth A., Ladell, Kristin, Price, David A., Guschina, Irina A., Rees, D. Aled, James, Philip E.

“…Lipoprotein-apheresis (apheresis) removes LDL-cholesterol in patients with severe dyslipidemia. However, reduction is transient, indicating that the long-term…”
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Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells by Ng, Julie, Marneth, Anna E., Griffith, Alec, Younger, Daniel, Ghanta, Sailaja, Jiao, Alan, Willis, Gareth, Han, Junwen, Imani, Jewel, Niu, Bailin, Keegan, Joshua W., Hancock, Brandon, Guo, Fei, Shi, Yang, Perrella, Mark A., Lederer, James A.

“…Abstract Novel therapeutics are urgently needed to prevent opportunistic infections in immunocompromised individuals undergoing cancer treatments or other…”
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Exosomes Could Offer New Options to Combat the Long-Term Complications Inflicted by Gestational Diabetes Mellitus by Floriano, Juliana Ferreira, Willis, Gareth, Catapano, Francesco, Lima, Patrícia Rodrigues de, Reis, Fabiana Vieira Duarte Souza, Barbosa, Angélica Mercia Pascon, Rudge, Marilza Vieira Cunha, Emanueli, Costanza

“…Gestational diabetes Mellitus (GDM) is a complex clinical condition that promotes pelvic floor myopathy, thus predisposing sufferers to urinary incontinence…”
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